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Manual of Coronary Chronic Total Occlusion Interventions - 1st Edition - ISBN: 9780124201293, 9780128004326

Manual of Coronary Chronic Total Occlusion Interventions

1st Edition

A Step-by-Step Approach

Author: Emmanouil Brilakis
Paperback ISBN: 9780124201293
eBook ISBN: 9780128004326
Imprint: Academic Press
Published Date: 19th October 2013
Page Count: 368


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Manual of Coronary Chronic Total Occlusion Interventions: A Step-by-Step Approach is a practical, easy to read reference for coronary chronic total occlusion interventions (CTO). Written by recognized national and international experts in the field, this reference compiles the steps necessary to preform, pitfalls to watch out for, and troubleshooting needed for coronary chronic total occlusion interventions (CTO).

Key Features

  • BMA Medical Book Awards 2014 - Highly Commended, Cardiology,2014,British Medical Association
  • A practical, case-oriented and easy to read reference with illustrations and step-by-step guidance for coronary chronic total occlusion interventions (CTO).
  • Includes expert guidance reviewed by leaders in the field with both large clinical experience with high success rates and extensive experience proctoring CTOs in multiple clinical centers.


This book is intended for researchers, physicians, cardiac catheterization laboratory personnel, technical staff, and industry professionals.

Table of Contents


List of Contributors


1. CTO Interventions: Definition, Prevalence, Indications, Guidelines

1.1 CTO Definition

1.2 Prevalence of CTOs

1.3 Indications and Potential Clinical Benefits of CTO PCI

1.4 Guidelines for CTO PCI

1.5 Appropriateness Use Criteria in CTO PCI

1.6 Contraindications to CTO PCI

1.7 Summary and Conclusions


2. Equipment

2.1 Sheaths

2.2 Guide Catheters

2.3 Microcatheters

2.4 Guidewires

2.5 Dissection/Re-Entry Equipment

2.6 Snares

2.7 “Uncrossable-Undilatable” Lesion Equipment

2.8 Intravascular Ultrasound

2.9 Complication Management Equipment

2.10 Radiation Protection

2.11 The “CTO cart”


3. The Basics: Timing, Dual Injection, Studying the Lesion, Access, Anticoagulation, Guide Support, Trapping

3.1 Timing

3.2 Dual Injection

3.3 Studying the Lesion

3.4 Vascular Access

3.5 Anticoagulation

3.6 Techniques to Increase Guide Catheter Support (Large Bore Guide, Active Guide Support, Guide Catheter Extensions, Anchor Techniques

3.7 Trapping


4. Antegrade Wire Escalation: The Foundation of CTO PCI

4.1 Special Situations


5. Antegrade Dissection/Re-entry

5.1 Knuckle Wire

5.2 CrossBoss

5.3 Stingray-Based Re-entry

5.4 Wire-Based Re-entry


6. The Retrograde Approach

6.1 Historical Perspective

6.2 Advantages of the Retrograde Approach

6.3 Special Equipment

6.4 Step-by-Step Description of the Procedure

6.5 Retrograde True Lumen Puncture

6.6 Retrograde Dissection/Re-entry

6.7 Antegrade Crossing

6.8 Special Retrograde CTO PCI Scenarios


7. Putting it all Together: The “Hybrid” Approach

7.1 Description of the “Hybrid” Algorithm

7.2 Impact of the “Hybrid” Approach


8. “Balloon Uncrossable” CTOs

8.1 Simultaneous Use of Strategies


9. “Balloon Undilatable” CTOs

9.1 Special Case Scenario: Stented “Balloon Undilatable” Lesions


10. Radiation Management During CTO PCI

10.1 Why is Radiation Management Important?

10.2 Essentials of Radiation Dose Management

10.3 Conclusions


11. Stenting of CTO Lesions

11.1 Stent Type

11.2 Stent Optimization

11.3 Antiplatelet Therapy After CTO Stenting


12. Complications

12.1 Acute Complications

12.2 Long-Term Complications

12.3 Conclusion


13. How to Build a Successful CTO Program


Appendix 1. Equipment Commonly Utilized in CTO Interventions

Appendix 2. Commonly Used Acronyms in CTO Interventions



No. of pages:
© Academic Press 2013
19th October 2013
Academic Press
Paperback ISBN:
eBook ISBN:

About the Author

Emmanouil Brilakis

Emmanouil S. Brilakis, MD, PhD, FACC, FAHA, FESC, FSCAI Dr. Brilakis is Director of the Center for Complex Coronary Interventions at the Minneapolis Heart Institute and the Center for. After graduating from Lycee Leonin de Patissia, Dr. Brilakis received his medical degree from the National Kapodistrian University of Athens, Greece. He trained in Internal Medicine, Cardiovascular Diseases and Interventional Cardiology at the Mayo Clinic. He also completed a Masters in Clinical Research at the Mayo Clinic and a PhD in Clinical Research at the National Kapodistrian University of Athens, Greece. He served as Director of the VA North Texas Healthcare System Cardiac Catheterization Laboratories from 2004 to 2016. Dr. Brilakis leads a large clinical trial group investigating treatment of chronic total occlusions, prevention and treatment of saphenous vein graft disease, prevention and management of complications, intracoronary imaging, antiplatelet treatment optimization post coronary stenting, radiation safety in the catheterization laboratory, and implementation of novel technologies in healthcare. He is Associate Editor for Circulation and on the editorial board of several other journals and on the Board of Directors of the Cardiovascular Innovations Foundation. He has authored or co-authored over 600 manuscripts and the Manual of CTO Interventions, now in its 2nd edition. He and is lecturing and proctoring at several institutions in the United States and abroad.

Affiliations and Expertise

Director, Center for Complex Coronary Interventions, Minneapolis Heart Institute, Minneapolis, Minnesota; Chairman, Center for Coronary Artery Disease, Minneapolis, MN, USA


BMA Medical Book Awards 2014 - Highly Commended, Cardiology, British Medical Association


"In addition to its comprehensive and up-to-date coverage of all aspects of CTO intervention, this easy-to-read, practical book serves as a valuable manual that helps novices learn CTO intervention techniques, and allows experienced operators to hone their skills."  Rating: 5, April 4, 2014
"Interventional cardiologists explain a new algorithmic approach to chronic total occlusion (CTO) intervention. Rather than reviewing angiograms and deciding whether a patient should get revascularization, the cardiologist will look at the ischemic burden and the patient's symptoms and use the angioram to determine how best to achieve revascularization. Among the topics are equipment, the retrograde approach, "balloon undilatable" CTOs, stenting CTO lesions…", January 2014

Ratings and Reviews