Manual of Chronic Total Occlusion Percutaneous Coronary Interventions

Manual of Chronic Total Occlusion Percutaneous Coronary Interventions

A Step-by-Step Approach

3rd Edition - December 15, 2022

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  • Author: Emmanouil Brilakis
  • Paperback ISBN: 9780323917872

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Manual of Chronic Total Occlusion Percutaneous Coronary Interventions: A Step-by-Step Approach, Third Edition is a practical reference for coronary chronic total occlusion (CTO) percutaneous coronary interventions (PCI). Written by recognized national and international experts in the field, this reference compiles the steps necessary to preform, what pitfalls to watch out for, and how to troubleshoot tactics. Written to bring a practical approach, this book is perfect for interventional cardiologists, interventional and general cardiology fellows, cardiology researchers, physicians, cardiac catheterization laboratory personnel, technical staff, industry professionals and everyone else interested in understanding the cutting-edge and rapidly evolving field of CTO PCI. In this new edition, new figures, images and algorithms have been developed to reflect the updates in CTO PCI during the past few years. In addition, this update links to approximately 200 CTO PCI cases that are accessible for free and hosted by the author on YouTube, with monthly updates on new cases. The structure of the book is completely revised to align it with the recently published Manual of Percutaneous Coronary Interventions (published in Oct 2020, also by Dr. Brilakis under the same imprint Academic Press).

Key Features

  • Provides step-by-step guidance on every technique used in coronary chronic total occlusion interventions using color figures and diagrams
  • Presents expert guidance by leaders in the field with both large clinical experience and extensive experience proctoring CTOs in multiple clinical centers
  • Contains links to approximately 200 YouTube videos that illustrate the concepts and techniques presented in the text
  • Includes the latest clinical experience, equipment, techniques and publications


Cardiology researchers, physicians, cardiac catheterization laboratory personnel, technical staff, and industry professionals

Table of Contents

  • 1. Planning
    2. Monitoring
    3. Pharmacology
    4. Access
    5. Engagement
    6. Angiography
    7. Determine target lesion(s)
    8. Wiring
    8.1. Antegrade
    8.2 ADR
    8.3 Retrograde
    8.4 Crossing algorithm
    9. Lesion preparation
    10. Stenting
    11. Arterial closure
    12. Physiology
    13. Imaging
    14. Hemodynamic support
    15. Complex subgroups
    15.1 Proximal cap ambiguity
    15.2 Impenetrable proximal cap
    15.3 Flush aorto-ostial CTOs
    15.4 Ostial circumflex and LAD CTOs
    15.5 Bifurcation at proximal cap
    15.6 Bifurcation at distal cap
    15.7 In-stent CTOs
    15.8 SVG CTOs
    15.9 Severe calcification
    15.10 Heart failure
    15.11 Prior failure
    15.12 Balloon uncrossable CTOs
    15.13 Balloon undilatable CTOs
    16. Complications
    17. Equipment
    18. How to start and improve a CTO PCI program

Product details

  • No. of pages: 600
  • Language: English
  • Copyright: © Academic Press 2023
  • Published: December 15, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323917872

About the Author

Emmanouil Brilakis

Emmanouil S. Brilakis, MD, PhD, FACC, FAHA, FESC, FSCAI Dr. Brilakis is Director of the Center for Complex Coronary Interventions at the Minneapolis Heart Institute and the Center for. After graduating from Lycee Leonin de Patissia, Dr. Brilakis received his medical degree from the National Kapodistrian University of Athens, Greece. He trained in Internal Medicine, Cardiovascular Diseases and Interventional Cardiology at the Mayo Clinic. He also completed a Masters in Clinical Research at the Mayo Clinic and a PhD in Clinical Research at the National Kapodistrian University of Athens, Greece. He served as Director of the VA North Texas Healthcare System Cardiac Catheterization Laboratories from 2004 to 2016. Dr. Brilakis leads a large clinical trial group investigating treatment of chronic total occlusions, prevention and treatment of saphenous vein graft disease, prevention and management of complications, intracoronary imaging, antiplatelet treatment optimization post coronary stenting, radiation safety in the catheterization laboratory, and implementation of novel technologies in healthcare. He is Associate Editor for Circulation and on the editorial board of several other journals and on the Board of Directors of the Cardiovascular Innovations Foundation. He has authored or co-authored over 600 manuscripts and the Manual of CTO Interventions, now in its 2nd edition. He and is lecturing and proctoring at several institutions in the United States and abroad.

Affiliations and Expertise

Director, Center for Complex Coronary Interventions, Minneapolis Heart Institute, Minneapolis, Minnesota; Chairman, Center for Coronary Artery Disease, Minneapolis, MN, USA

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