Manganese in Metabolism and Enzyme Function - 1st Edition - ISBN: 9780126290509, 9780323149983

Manganese in Metabolism and Enzyme Function

1st Edition

Editors: Vern L. Schramm
eBook ISBN: 9780323149983
Imprint: Academic Press
Published Date: 28th January 1986
Page Count: 448
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Manganese in Metabolism and Enzyme Function provides an understanding of the various biological roles of the trace levels of manganese found in mammalian systems. This text discusses the nutritional aspects of manganese in mammals. This book is organized into three sections encompassing 19 chapters. Section I discusses the effects of manganese deficiency, including abnormal pancreatic action and reduced pancreatic manganese in humans and laboratory animals. This text considers the criteria for adding manganese to infant formulas that are commercially available. Section II explores the effects of Mn(II) in protein kinases, protein phosphatases, and other enzymes. The reader is introduced to the electron paramagnetic resonance spectroscopic probes of manganese function. Other chapters discuss the extrinsic tag technique used to study the bioavailability of trace elements, such as iron and zinc. Finally, Section III examines the biophysical, biochemical, and physiological properties and uses of manganese. Nutritionists, toxicologists, scientists, and researchers will find this book extremely useful.

Table of Contents

Preface Section I Manganese Nutrition and Transport

1. Mammalian Manganese Metabolism and Manganese Uptake and Distribution in Rat Hepatocytes 2. Bioavailability of Manganese in Milk Studied in in Vitro and in Vivo Systems 3. Manganese Toxicity in Man and Experimental Animals 4. Interaction of Manganese with Cellular Calcium Homeostasis 5. Mn(II) and Ca(II) Transport in Mitochondria 6. Mn(II) and Glycosyltransferases Essential for Skeletal Development 7. Hormonal Regulation of Manganese Metabolism

Section II Enzymology and Metabolic Pathways 8· Evaluation of Mn(II) in Metabolic Regulation: Analysis of Proposed Sites for Regulation

9. Possible Sites of Mn(II) Action on Carbohydrate Metabolism in the Liver 10. Manganese and Pyruvate Carboxylase 11. Manganese and Phosphoenolpyruvate Carboxykinase 12. Manganese-Catalase and Manganese Superoxide Dismutase: Spectroscopic Similarity with Functional Diversity 13. Interactions of Mn(II) with Mammalian Glutamine Synthetase 14. Properties and Regulation of Mouse Liver Arginase 15. Kinetic and Magnetic Resonance Studies of the Interaction of Mn2+ Substrates and Templates with DNA Polymerases 16. The Organization and Function of Manganese in the Water-Oxidizing Complex of Photosynthesis

Section III Biophysical Probes for Manganese and Its Interactions with Specific Binding Sites

17. Manganese: An Overview of Chemical Properties 18. Methods of Mn(II) Determination 19. Manganese as a Probe of Metal Ion Function 20. Manganese in Proteins with Multiple Metal Ion Binding Sites 21. Manganese Superoxide Dismutase: Structure and Properties



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© Academic Press 1986
Academic Press
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About the Editor

Vern L. Schramm

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