Manganese in Metabolism and Enzyme Function

Manganese in Metabolism and Enzyme Function

1st Edition - January 28, 1986

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  • Editor: Vern L. Schramm
  • eBook ISBN: 9780323149983

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Manganese in Metabolism and Enzyme Function provides an understanding of the various biological roles of the trace levels of manganese found in mammalian systems. This text discusses the nutritional aspects of manganese in mammals. This book is organized into three sections encompassing 19 chapters. Section I discusses the effects of manganese deficiency, including abnormal pancreatic action and reduced pancreatic manganese in humans and laboratory animals. This text considers the criteria for adding manganese to infant formulas that are commercially available. Section II explores the effects of Mn(II) in protein kinases, protein phosphatases, and other enzymes. The reader is introduced to the electron paramagnetic resonance spectroscopic probes of manganese function. Other chapters discuss the extrinsic tag technique used to study the bioavailability of trace elements, such as iron and zinc. Finally, Section III examines the biophysical, biochemical, and physiological properties and uses of manganese. Nutritionists, toxicologists, scientists, and researchers will find this book extremely useful.

Table of Contents

  • Preface

    Section I Manganese Nutrition and Transport

    1. Mammalian Manganese Metabolism and Manganese Uptake and Distribution in Rat Hepatocytes

    2. Bioavailability of Manganese in Milk Studied in in Vitro and in Vivo Systems

    3. Manganese Toxicity in Man and Experimental Animals

    4. Interaction of Manganese with Cellular Calcium Homeostasis

    5. Mn(II) and Ca(II) Transport in Mitochondria

    6. Mn(II) and Glycosyltransferases Essential for Skeletal Development

    7. Hormonal Regulation of Manganese Metabolism

    Section II Enzymology and Metabolic Pathways

    8· Evaluation of Mn(II) in Metabolic Regulation: Analysis of Proposed Sites for Regulation

    9. Possible Sites of Mn(II) Action on Carbohydrate Metabolism in the Liver

    10. Manganese and Pyruvate Carboxylase

    11. Manganese and Phosphoenolpyruvate Carboxykinase

    12. Manganese-Catalase and Manganese Superoxide Dismutase: Spectroscopic Similarity with Functional Diversity

    13. Interactions of Mn(II) with Mammalian Glutamine Synthetase

    14. Properties and Regulation of Mouse Liver Arginase

    15. Kinetic and Magnetic Resonance Studies of the Interaction of Mn2+ Substrates and Templates with DNA Polymerases

    16. The Organization and Function of Manganese in the Water-Oxidizing Complex of Photosynthesis

    Section III Biophysical Probes for Manganese and Its Interactions with Specific Binding Sites

    17. Manganese: An Overview of Chemical Properties

    18. Methods of Mn(II) Determination

    19. Manganese as a Probe of Metal Ion Function

    20. Manganese in Proteins with Multiple Metal Ion Binding Sites

    21. Manganese Superoxide Dismutase: Structure and Properties


Product details

  • No. of pages: 448
  • Language: English
  • Copyright: © Academic Press 1986
  • Published: January 28, 1986
  • Imprint: Academic Press
  • eBook ISBN: 9780323149983

About the Editor

Vern L. Schramm

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