Management of GI and Pancreatic Neuroendocrine Tumors,An Issue of Surgical Oncology Clinics of North America

1st Edition, Volume 29-2 - March 10, 2020
Editor: James R. Howe
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 6 9 6 0 1 - 2
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 6 9 6 0 2 - 9

This issue of Surgical Oncology Clinics of North America, guest edited by Dr. James Howe, is devoted to Management of GI and Pancreatic Neuroendocrine Tumors. Dr. Howe has… Read more

Management of GI and Pancreatic Neuroendocrine Tumors,An Issue of Surgical Oncology Clinics of North America

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This issue of Surgical Oncology Clinics of North America, guest edited by Dr. James Howe, is devoted to Management of GI and Pancreatic Neuroendocrine Tumors. Dr. Howe has assembled expert authors to review the following topics: Introduction and History of GI and Pancreatic Neuroendocrine Tumors (GEPNETs); Surgical Management of Colorectal Neuroendocrine Tumors; Management of Metastatic GEPNETs; Pathologic considerations in GEPNETs; Medical Management of GEPNETs; Workup of GEPNETs; Peptide Radioreceptor Therapy (PRRT); Surgical Management of Small Bowel Neuroendocrine Tumors; The Role of Functional Imaging in GEPNETs; Surgical Management of Pancreatic Neuroendocrine Tumors; Surgical Management of Other Gastric and Duodenal Neuroendocrine Tumors; and more!

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Erratum
Foreword
Preface
Evolution of Neuroendocrine Tumor Therapy
Key points
Surgery/cytoreduction
Octreotide/lanreotide
Peptide receptor radionuclide therapy and theranostics
Workup of Gastroenteropancreatic Neuroendocrine Tumors
Key points
Introduction
Clinical presentation
Incidental presentation of neuroendocrine tumors
Symptomatic presentation of neuroendocrine tumors
The role of imaging in workup of patients with neuroendocrine tumors of the gastrointestinal tract or pancreas
The role of biochemical markers in workup of patients with neuroendocrine tumors of the gastrointestinal tract or pancreas
The role of biopsy in workup of patients with neuroendocrine tumors of the gastrointestinal tract or pancreas
Summary
Pathologic Considerations in Gastroenteropancreatic Neuroendocrine Tumors
Key points
Introduction
General features of neuroendocrine neoplasms
General neuroendocrine marker immunohistochemistry
Immunohistochemistry to distinguish epithelial from nonepithelial neuroendocrine neoplasms
Differentiation
Grade
World Health Organization classification of neuroendocrine neoplasms
Site-specific considerations
Immunohistochemistry for site of origin assignment in metastasis of occult origin
Immunohistochemistry to distinguish well-differentiated neuroendocrine tumor G3 from poorly differentiated neuroendocrine carcinoma
Reporting of biopsy and resection specimens
Nuclear Imaging of Neuroendocrine Tumors
Key points
Ga-68 dota-sstr pet/ct in diagnosis of gastroenteropancreatic neuroendocrine tumors
Ga-68 dota-sstr pet/ct in staging of gastroenteropancreatic neuroendocrine tumors
Ga-68 dota-sstr pet/ct in identification of unknown primary neuroendocrine tumor in patients presenting with metastases
Ga-68 dota-sstr pet/ct in detection of recurrence and restaging
Ga-68 dota-sstr pet/ct to determine eligibility for peptide receptor radionuclide therapy
Ga-68 dota-sstr pet/ct in monitoring response to therapy
Ga-68 dota-sstr pet/mri in neuroendocrine tumors
Summary
Management of Small Bowel Neuroendocrine Tumors
Key points
Introduction
Epidemiology
Presentation
Diagnosis
Surgical management
Surgical approach
Liver-directed therapy
Carcinoid heart disease
Systemic treatment
Prognosis
High-grade disease
Summary
Surgical Management of Pancreatic Neuroendocrine Tumors
Key points
Incidence, staging, diagnosis
Tumor location
Resection of the primary tumor
Resection of regional lymph nodes
Surgical management of liver metastases
Prognosis
Management of Other Gastric and Duodenal Neuroendocrine Tumors
Key points
Introduction
Incidence
Location and clinical features
Diagnosis and staging
Resection of primary tumor
Resection of regional nodal metastases
Management of liver metastases
Prognosis
Summary
Neuroendocrine Tumors of the Appendix, Colon, and Rectum
Key points
Introduction
Incidence
Diagnosis and staging
Location
Resection of the primary tumor and regional lymph nodes
Prognosis
Summary
Management of Metastatic GEPNETs
Key points
Incidence
Hepatic metastases
Peritoneal metastasis
Bone metastasis
Medical Management of Gastroenteropancreatic Neuroendocrine Tumors
Key points
Introduction
Somatostatin analogues
Historical results with chemotherapy
Chemotherapy in nonpancreatic gastrointestinal carcinoid tumors
Chemotherapy in pancreatic neuroendocrine tumors
Capecitabine and temozolomide for pancreatic neuroendocrine tumors
Role of interferons
Molecular targeted therapies
Future directions
Summary
Overview and Current Status of Peptide Receptor Radionuclide Therapy
Key points
Background/concepts
Treatment preparation and procedure
Efficacy of peptide receptor radionuclide therapy in gastroenteropancreatic neuroendocrine tumors
Side effects
Future prospects

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James R. Howe