Mammalian Protein Metabolism

Mammalian Protein Metabolism

Volume III

1st Edition - January 1, 1969

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  • Editor: H. N. Munro
  • eBook ISBN: 9781483272900

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Mammalian Protein Metabolism, Volume III, provides an overview of the state of knowledge on mammalian protein metabolism. It enlarges and adds depth to the picture of protein metabolism provided by Volumes I and II. The present volume covers two aspects of protein metabolism not specifically considered in the earlier parts of the treatise. First, there is a section of three chapters dealing with changes in protein metabolism during evolution and during growth and development. At its most fundamental level, this part deals in reality with an aspect of regulation of protein metabolism, since differences in metabolism between species and changes occurring during growth are both outward expressions of genetic control mechanisms that determine the form and characteristics of an animal. The other section in this volume is a survey of methods appropriate to the study of protein metabolism in mammals. This part of the work should prove of special interest to investigators who require a critical evaluation of the possibilities and limitations of methods applicable to intact animals.

Table of Contents

  • List of Contributors


    Preface to Volumes I and II

    Contents of Other Volumes

    Part IV Protein Metabolism during Evolution and Development of Mammals

    An Introduction to Protein Metabolism during the Evolution and Development of Mammals

    I. Introduction

    II. Origin of Life

    III. Evolution of Species


    Chapter 24 Evolution of Protein Molecules

    I. Introduction

    II. Evolutionary Changes in Protein Structure

    III. Functional Differentiation of Proteins as a Result of Evolutionary Divergence

    IV. Taxonomic Serology in the Study of Evolution

    V. Statistical Procedures and Computer Techniques

    VI. Conclusion


    Chapter 25 Evolution of Protein Metabolism in Mammals

    I. Introduction

    II. Evolution of Protein Metabolism in Animals

    III. Species and Individual Differences in the Protein Metabolism of Mammals

    IV. Effect of Species Size on the Protein Metabolism of Mammals

    V. Conclusions


    Chapter 26 Protein Metabolism during Growth and Development

    I. Introduction

    II. Rate of Growth: Continuous or Discontinuous?

    III. Dynamic Aspects of Protein Metabolism during Development

    IV. The Influence of Diet on Development

    V. Restatement of the Problem


    Part V Technical Aspects of the Study of Protein Metabolism

    A General Survey of Techniques Used in Studying Protein Metabolism in Whole Animals and Intact Cells

    I. Introduction

    II. Use of Isotopes in the Study of Protein Metabolism

    III. Methods for Studying Protein Metabolism in Whole Animals and Man

    IV. Methods for Studying Protein Metabolism in Isolated Tissues and Cells

    V. Application of Cytochemical Techniques to Protein Metabolism


    Chapter 27 Application of Computers to the Study of Protein Metabolism

    I. Introduction

    II. General Description of Computers

    III. Relevant Mathematical and Biological Backgrounds

    IV. Compartmentation

    V. Digital Simulation of Amino Acid Metabolism

    VI. Protein Synthesis and Its Control Studied with Analog Computer Models

    VII. Probable Future Developments


    Chapter 28 The Assessment of Protein Nutrition and Metabolism in the Whole Animal, with Special Reference to Man

    I. Introduction

    II. The Protein Content of the Whole Body and of Organs and Tissues

    III. The Effect of Protein Depletion on the Distribution of Protein in Organs and Tissues

    IV. Nitrogen Balance

    V. The Value of Measurements on Blood and Urine for the Assessment of Protein Nutrition

    VI. Measurement of Total Amino Acid or Nitrogen Turnover

    VII. The Effect of Nutritional State on Plasma Albumin Turnover

    VIII. General Conclusions


    Chapter 29 Methodology of Protein Evaluation

    I. Introduction

    II. Weight Gain Methods

    III. Nitrogen Balance Methods

    IV. Net Protein Utilization

    V. Comparison of Nitrogen Utilization and Weight Gain Methods

    VI. Chemical Scoring Methods

    VII. Miscellaneous Methods

    VIII. Availability of Amino Acids

    IX. Supplementary Value of Proteins

    X. Evaluation of Diets

    XI. Significance of Amino Acid Requirements in Methods for Protein Evaluation

    XII. Summary


    Chapter 30 Analysis of Tissues and Body Fluids for Nitrogenous Constituents

    I. Introduction

    II. Estimation of Total Nitrogen

    III. Estimation of Protein

    IV. Measurement of Nucleic Acids in Tissues

    V. Measurement of Tissue Phospholipid Nitrogen

    VI. Measurement of Nitrogen-Containing Small Molecules

    VII. General Aspects of Tissue Analysis for Nitrogenous Constituents


    Author Index

    Subject Index

Product details

  • No. of pages: 590
  • Language: English
  • Copyright: © Academic Press 1969
  • Published: January 1, 1969
  • Imprint: Academic Press
  • eBook ISBN: 9781483272900

About the Editor

H. N. Munro

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