Male Infertility,An Issue of Urologic Clinics

1st Edition, Volume 47-2 - April 15, 2020
Editor: James M. Hotaling
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 7 1 2 0 7 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 7 1 2 0 8 - 8

Together with Consulting Editor Dr. Samir Taneja, Dr. Badrinath Konety has put together a comprehensive issue that addresses the latest clinical updates in Male Infertility.… Read more

Male Infertility,An Issue of Urologic Clinics

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Together with Consulting Editor Dr. Samir Taneja, Dr. Badrinath Konety has put together a comprehensive issue that addresses the latest clinical updates in Male Infertility. Expert authors have contributed clinical review articles on the following topics: Cutting edge evaluation in male infertility; Optimal endocrine evaluation and treatment; Sperm extraction in obstructive azoospermia: What’s next; FNA vs. microTESE; ROSI (round spermatid injection); Reproductive Urology in the context of an IVF practice; Care delivery in male infertility; Qualitative research in male infertility; Male Infertility & Somatic Health; DNA fragmentation: Does testicular sperm make sense; CRISPR & Genetics of Male Infertility after whole genome sequencing; Transgenerational epigenetics: A window into paternal health influences on offspring; Spermatogonial Stem Cell Culture in oncofertility; Personalized medicine for the infertile male; and Male Infertility & The future of IVF. Readers will come away with the clinical information they need to improve outcomes in patients with infertility.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Cutting-Edge Evaluation of Male Infertility
Key points
Introduction
Basic evaluation
Extended evaluation
Summary
Optimal Endocrine Evaluation and Treatment of Male Infertility
Key points
Evaluation
Treatment
Hypergonadotropic hypogonadism
Hypogonadotropic hypogonadism
Future directions
Summary
Sperm Extraction in Obstructive Azoospermia: What’s Next?
Key points
Introduction
History and evolution of sperm extraction techniques
Current role of epididymal and testicular sperm retrieval in obstructive azoospermia
Future directions
Summary
Testicular Mapping: A Roadmap to Sperm Retrieval in Nonobstructive Azoospermia?
Key points
Setting the stage
Upfront testicular sperm retrieval
Testicular mapping
High Sperm DNA Damage: Does Testicular Sperm Make Sense?
Key points
Background
Summary
Round Spermatid Injection
Key points
Introduction
Spermatogenesis and sperm function
History of assisted reproduction in azoospermia
Round spermatid injection in animal models
Clinical use of round spermatid injection
Challenges and innovation
Summary
The Role of the Urologist in a Reproductive Endocrinology and Infertility Practice
Key points
Introduction
The male infertility evaluation
The role of a urologist within a fertility practice
Future directions
Summary
Care Delivery for Male Infertility: The Present and Future
Key points
Introduction
Scope of male infertility and importance of male infertility evaluations and treatments
Insurance coverage for infertility care
Cost of infertility care
Increasing public awareness and market demand for services and coverage of infertility care
Future innovations in fertility clinic organizations and clinical practice structures
Future directions and summary
Qualitative Research in Male Infertility
Key points
Introduction
Quantitative versus qualitative research
Qualitative research methodology
Qualitative data analysis
Judging qualitative research
Strengths and limitations
Applications to male infertility
Mixed methods research
Summary
Male Infertility and Somatic Health
Key points
Introduction
Genetic associations
Developmental associations
Lifestyle associations
Male infertility and oncologic disease
Male infertility and nononcologic chronic diseases
Male infertility and mortality
Summary
Transgenerational Epigenetics: A Window into Paternal Health Influences on Offspring
Key points
Introduction
Transgenerational inheritance
Two subcategories of epigenetic inheritance: programmed and disruptive
Summary
Spermatogonial Stem Cell Culture in Oncofertility
Key points
Introduction
Spermatogonial stem cell transplantation to restore fertility
Sorting methods to isolate and enrich spermatogonial stem cells as well as eliminate malignant contamination
Human spermatogonial stem cell culture: components and methods of analysis
Challenges, opportunities, and future directions
Personalized Medicine in Infertile Men
Key points
What is personalized medicine?
What is known about male infertility, what remains to be defined, and how close are we to the personalized medicine in male infertility
Personalized reproductive medicine
New approaches: omics technology as a diagnostic tool and infertility biomarkers
New directions
Summary
Male Infertility and the Future of In Vitro Fertilization
Key points
Introduction
The relationship between epigenetics, transgenerational epigenetic inheritance, and in vitro fertilization
Single-nucleotide polymorphisms and copy number variants associated with male infertility
DNA damage
Fresh versus frozen sperm
Obesity and sperm epigenetics
The impact of paternal age on sperm genetics and pregnancy outcomes
Microfluidic devices and sperm selection
Summary