Major Problems in Developmental Biology

Major Problems in Developmental Biology

1st Edition - January 1, 1966

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  • Editor: Michael Locke
  • eBook ISBN: 9780323151139

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Major Problems in Developmental Biology contains the proceedings of the 25th Symposium of the Society for Developmental Biology, held in Haverford, Pennsylvania, in June 1966. The papers explore some of the major problems in developmental biology, particularly those relating to cell differentiation, movements, and death; patterning; and intercellular regulation in plants. Organized into 11 chapters, this book begins with an overview of the growth and development of developmental biology as a scientific discipline, with emphasis on the role of the Society for Developmental Biology, and in particular its symposia, in the emergence of the field. The book then discusses the intra- and extracellular factors impinging upon the nucleus and regulating cell differentiation. Some chapters focus on the dynamics of determination in cell systems of insects, morphogenetic movements of animal cells, and patterns at the cell and tissue levels. The reader is also introduced to the correlations between protein structure and function in relation to cell dynamics and differentiation, along with the physiological, biochemical, and molecular biological aspects of intercellular regulation in plants and the role of cell surface in carcinogenesis. The book concludes by suggesting directions for research into the ontogeny of behavior. This book is a valuable source of information for developmental biologists.

Table of Contents

  • Contributors and Presiding Chairman

    The Growth and Development of Developmental Biology


    The State of Embryology in 1938 and 1939

    The State of Some Nonembryological Areas of Biology from 1938 to 1940

    Some Society Earlies

    Organizers of the Symposia and Officers of the Society from 1939 to 1965


    The Keys to Change: Factors Regulating Differentiation


    The Constancy Hypothesis

    Differential Replication of DNA

    Differential Release of Information: Puffing and Compacted Regions

    DNA and RNA Synthesis during Oogenesis and Early Development

    The Virus Susceptibility of Differentiating Cells

    DNA Replication and Antibody Formation

    Factors Regulating Differentiation



    Dynamics of Determination



    Fields and Gradients

    The Basic Terminology

    The Nature of Fields

    The Temporal Characteristics of Fields

    The Causal Complexity of the Field

    Abstractions from the Total Field Concept



    Morphogenetic Cell Movements


    Cell Movements in Culture

    Mechanism of Morphogenetic Movements



    The Formation of Patterns in Development


    Patterns in Bird Feathers

    Pigment Patterns in Amphibians

    Bristle Patterns in Insects

    Stomatal Patterns in Plant Leaves, with a Note on Drosophila Ocelli and Turing's Model

    Scales, Color Patterns, and Hinges of Butterfly Wings





    Protein Structure in Relation to Cell Dynamics and Differentiation

    Three-Dimensional Structure of Proteins

    Protein Flexibility in Relation to Enzyme Action

    Protein Flexibility in Relation to Activation Processes

    Protein Flexibility in Relation to Inhibition Processes

    A Mechanism for Protein Conformational Changes

    Cooperative Effects

    Protein Flexibility in Relation to Other Biological Processes

    Protein Flexibility in the Control of Protein Synthesis

    Amplification of Biological Changes

    Suggestions for Mechanisms of Differentiation


    Intercellular Regulation in Plants

    Pharmacological Aspects

    Physiological Aspects

    Comparative Biochemical Aspects

    Molecular Biological Aspects

    A Look at the Past and Present

    Intercellular Regulation in Plants: Short-Distance Effects


    Cell Death in Morphogenesis


    Integration of Patterns of Growth and Death in Shaping the Vertebrate Limb

    Control of the Death Program

    Execution of the Death Sentence

    General Conclusions


    Fact and Theory about the Cell Surface in Carcinogenesis

    Contact Inhibition

    Studies of Cell Membranes

    The Growth of Cells in Tissue Culture

    Demonstration of "Conditioning Factor"

    Conditioning of Medium by Rous Sarcoma Cells

    General Discussion



    Starting Points for Research in the Ontogeny of Behavior

    Electrical Activity of Neurons during Maturation

    Effects of Growth Factors and Hormones on Neuronal Maturation

    Effects of Function on Neuronal Maturation

    Are Neuronal Connections Predetermined during Development?

    Formation of Connections between the Retina and Brain

    Specification of Retinal Ganglion Cells


    Author Index

    Subject Index

Product details

  • No. of pages: 420
  • Language: English
  • Copyright: © Academic Press 1966
  • Published: January 1, 1966
  • Imprint: Academic Press
  • eBook ISBN: 9780323151139

About the Editor

Michael Locke

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