Major Problems in Developmental Biology - 1st Edition - ISBN: 9780123956187, 9780323151139

Major Problems in Developmental Biology

1st Edition

Editors: Michael Locke
eBook ISBN: 9780323151139
Imprint: Academic Press
Published Date: 1st January 1966
Page Count: 420
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Major Problems in Developmental Biology contains the proceedings of the 25th Symposium of the Society for Developmental Biology, held in Haverford, Pennsylvania, in June 1966. The papers explore some of the major problems in developmental biology, particularly those relating to cell differentiation, movements, and death; patterning; and intercellular regulation in plants. Organized into 11 chapters, this book begins with an overview of the growth and development of developmental biology as a scientific discipline, with emphasis on the role of the Society for Developmental Biology, and in particular its symposia, in the emergence of the field. The book then discusses the intra- and extracellular factors impinging upon the nucleus and regulating cell differentiation. Some chapters focus on the dynamics of determination in cell systems of insects, morphogenetic movements of animal cells, and patterns at the cell and tissue levels. The reader is also introduced to the correlations between protein structure and function in relation to cell dynamics and differentiation, along with the physiological, biochemical, and molecular biological aspects of intercellular regulation in plants and the role of cell surface in carcinogenesis. The book concludes by suggesting directions for research into the ontogeny of behavior. This book is a valuable source of information for developmental biologists.

Table of Contents

Contributors and Presiding Chairman

The Growth and Development of Developmental Biology


The State of Embryology in 1938 and 1939

The State of Some Nonembryological Areas of Biology from 1938 to 1940

Some Society Earlies

Organizers of the Symposia and Officers of the Society from 1939 to 1965


The Keys to Change: Factors Regulating Differentiation


The Constancy Hypothesis

Differential Replication of DNA

Differential Release of Information: Puffing and Compacted Regions

DNA and RNA Synthesis during Oogenesis and Early Development

The Virus Susceptibility of Differentiating Cells

DNA Replication and Antibody Formation

Factors Regulating Differentiation



Dynamics of Determination



Fields and Gradients

The Basic Terminology

The Nature of Fields

The Temporal Characteristics of Fields

The Causal Complexity of the Field

Abstractions from the Total Field Concept



Morphogenetic Cell Movements


Cell Movements in Culture

Mechanism of Morphogenetic Movements



The Formation of Patterns in Development


Patterns in Bird Feathers

Pigment Patterns in Amphibians

Bristle Patterns in Insects

Stomatal Patterns in Plant Leaves, with a Note on Drosophila Ocelli and Turing's Model

Scales, Color Patterns, and Hinges of Butterfly Wings





Protein Structure in Relation to Cell Dynamics and Differentiation

Three-Dimensional Structure of Proteins

Protein Flexibility in Relation to Enzyme Action

Protein Flexibility in Relation to Activation Processes

Protein Flexibility in Relation to Inhibition Processes

A Mechanism for Protein Conformational Changes

Cooperative Effects

Protein Flexibility in Relation to Other Biological Processes

Protein Flexibility in the Control of Protein Synthesis

Amplification of Biological Changes

Suggestions for Mechanisms of Differentiation


Intercellular Regulation in Plants

Pharmacological Aspects

Physiological Aspects

Comparative Biochemical Aspects

Molecular Biological Aspects

A Look at the Past and Present

Intercellular Regulation in Plants: Short-Distance Effects


Cell Death in Morphogenesis


Integration of Patterns of Growth and Death in Shaping the Vertebrate Limb

Control of the Death Program

Execution of the Death Sentence

General Conclusions


Fact and Theory about the Cell Surface in Carcinogenesis

Contact Inhibition

Studies of Cell Membranes

The Growth of Cells in Tissue Culture

Demonstration of "Conditioning Factor"

Conditioning of Medium by Rous Sarcoma Cells

General Discussion



Starting Points for Research in the Ontogeny of Behavior

Electrical Activity of Neurons during Maturation

Effects of Growth Factors and Hormones on Neuronal Maturation

Effects of Function on Neuronal Maturation

Are Neuronal Connections Predetermined during Development?

Formation of Connections between the Retina and Brain

Specification of Retinal Ganglion Cells


Author Index

Subject Index


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© Academic Press 1966
Academic Press
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About the Editor

Michael Locke

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