Major Methods of Peptide Bond Formation - 1st Edition - ISBN: 9780123042019, 9781483217963

Major Methods of Peptide Bond Formation

1st Edition

The Peptides Analysis, Synthesis, Biology, Vol. 1

Editors: Erhard Gross Johannes Meienhofer
eBook ISBN: 9781483217963
Imprint: Academic Press
Published Date: 28th April 1979
Page Count: 454
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Description

The Peptides: Analysis, Synthesis, Biology, Volume 1: Major Methods of Peptide Bond Formation provides comprehensive and critical reviews of important developments in three major areas of peptide research—analysis, synthesis, and biology.

This book discusses the nature of the peptide bond, coupling between amino acid residues, and catalysis of active ester reactions. The formation of hydrazides, reactions of carbodiimides with amines, and mixed carbonic anhydride method of peptide synthesis are also elaborated. This publication likewise covers the control of racemization during peptide synthesis, strategies for minimizing racemization during amide-forming steps, and assays for chiral purity.

This volume is suitable for students, specialists, and scientists from a broad range of disciplines concerned with peptides.

Table of Contents


List of Contributors


Preface


Nomenclature and Abbreviations


Chapter 1 The Peptide Bond


I Introduction


II Nature of the Peptide Bond


III Cleavage of the Peptide Bond


IV Formation of the Peptide Bond


V Conclusion and Outlook


References


Chapter 2 The Formation of Peptide Bonds: A General Survey


I Introduction


II Coupling between Amino Acid Residues


III Ab Initio Assembly of the Backbone


IV Conclusions


References


Chapter 3 Active Esters in Peptide Synthesis


I The Development of Active Esters


II Classes of Active Esters


III Preparation of Active Esters


IV Catalysis of Active Ester Reactions


V Side Reactions


VI Active Esters and the Strategy of Peptide Synthesis


VII Active Esters in Various Techniques of Peptide Synthesis


VIII Conclusions


References


Chapter 4 The Azide Method in Peptide Synthesis


I Introduction


II Experimental Procedure


III The Formation of Hydrazides


IV The Generation of Azides


V Azide Segment Condensation


VI Special Applications


VII Opportunities and Constraints


References


Chapter 5 The Carbodiimide Method


I Introduction


II Mechanism of Carboxyl Activation


III Reaction Conditions for Dicyclohexyl-Carbodiimide-Mediated Peptide Bond Formation


IV Reactions of Carbodiimides with Amines


References


Chapter 6 The Mixed Carbonic Anhydride Method of Peptide Synthesis


I Introduction


II The Experimental Procedure


III Reaction Conditions


IV Coupling Reagents: EEDQ and IIDQ

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Details

No. of pages:
454
Language:
English
Copyright:
© Academic Press 1979
Published:
Imprint:
Academic Press
eBook ISBN:
9781483217963

About the Editor

Erhard Gross

Johannes Meienhofer

Ratings and Reviews