Macrophages in the Human Body

Macrophages in the Human Body

A Tissue Level Approach

1st Edition - June 8, 2022

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  • Editors: Niels Saraiva Camara, Tárcio Teodoro Braga
  • eBook ISBN: 9780128213865
  • Paperback ISBN: 9780128213858

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Description

Through recent research, there has been a significant number of findings involving the biology of macrophages. Beyond the 1st line of defense, macrophages have several specific characteristics across different tissues, organs, and systems. Macrophages comprehend a heterogeneous phagocytic population with wide range phenotypes, and tissue-specific functions, such as bone resorption, extracellular matrix production, red blood cells and bacteria removal, among others. Through innate immune receptors macrophages can modulate several pathways that culminate in the production of various types of inflammatory mediators such as chemokines, cytokines, oxygen reactive species, and lipid mediators which ultimately altered the behavior of other cells. Moreover, environment signals modify and induce metabolic reprograming that it alters phenotype and functions.Macrophages in the Human Body: A Tissue Level Approach presents a current overview of the diversity of macrophages across multiple human body systems, their phenotype, function and metabolic characteristics. It covers translational aspects where there is research support to indicate the therapeutic potential.

Key Features

  • Covers translational aspects where there is research support to indicate potential therapeutic potential
  • Aims at presenting a current overview of the diversity of macrophages across multiple human body systems, their phenotype, function and metabolic characteristics
  • Introduces Macrophages generally and dive into the organ/tissue/specific representations covering their phenotype, function, and metabolic characteristics
  • Brings updated aspects of macrophages biology

Readership

Researchers, clinicians and students at PhD level and above in Biology, mainly in Immunology and cellular biology. Multidisciplinary researchers and Physicians in Infectiology, Rheumatology, Neurology, Nephrology, Orthopedy, Hematology and other medical specialties

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Chapter 1: Macrophages: From Metchnikoff to 2020 and ahead
  • Abstract
  • References
  • Chapter 2: Macrophage differentiation
  • Abstract
  • Background
  • Macrophage origin and plasticity
  • New macrophage spectral phenotype
  • Concluding remarks
  • References
  • Chapter 3: Metabolic requirement for macrophages
  • Abstract
  • Introduction
  • Spectrum of macrophages and immunometabolism
  • References
  • Chapter 4: Spleen, lymph nodes, and lymphoid tissues—Inflammatory system
  • Abstract
  • Introduction
  • Spleen
  • The splenic red pulp region
  • Red pulp macrophages
  • The splenic white pulp
  • White pulp macrophages
  • The splenic marginal zone
  • Macrophages in the marginal zone
  • Marginal zone macrophages and tissue immunity
  • Marginal metallophilic macrophages and tissue immunity
  • Removal of apoptotic cells by macrophages in the marginal zone and immune tolerance
  • Lymph node
  • Subcapsular sinus macrophages
  • Medullary sinus macrophages and medullary cord macrophages
  • Lymph node macrophages development
  • References
  • Chapter 5: Kidney—Inflammation and remodeling
  • Abstract
  • Macrophage heterogeneity and plasticity
  • Macrophages in acute kidney injury
  • Macrophages in chronic kidney disease
  • Macrophages during different kidney disease stages
  • Therapeutic prospects of macrophage function
  • Conclusions
  • References
  • Chapter 6: Dermal macrophages in health and disease
  • Abstract
  • Acknowledgments
  • Introduction
  • Dermal macrophage characterization and phenotype
  • DM activation profile
  • Dermal macrophage ontogeny
  • Dermal macrophage functions
  • Final considerations and future directions
  • References
  • Chapter 7: Bone—From macrophage to osteoclast and osteolytic diseases
  • Abstract
  • Introduction and historical background
  • Molecular signature for osteoclast differentiation
  • Osteolytic diseases
  • References
  • Chapter 8: Microglia and border-associated macrophages in the central nervous system
  • Abstract
  • CNS macrophages heterogeneity and beyond
  • Macrophage’s phenotype in the brain
  • General functions of microglia and BAMs
  • Macrophages in CNS disorders
  • Aging
  • Alzheimer’s disease
  • Multiple sclerosis
  • Brain cancer
  • Stroke
  • Other brain’s disease
  • Concluding remarks
  • References
  • Chapter 9: Intestines—Inflammatory and digestive system
  • Abstract
  • Acknowledgments
  • Introduction
  • Macrophages: Ontogeny, subtypes, and classic markers
  • Gastrointestinal inflammation and colorectal cancer
  • Metabolic pathways macrophages
  • Microbial metabolites in intestinal macrophages
  • Conclusion
  • References
  • Chapter 10: Lungs—Inflammatory and respiratory system
  • Abstract
  • Lung-resident macrophage ontogeny and phenotype
  • Lung macrophages in homeostatic conditions
  • Lung macrophages in inflammatory conditions
  • Conclusion remarks
  • References
  • Chapter 11: Macrophages in the immune-endocrine milieu of reproductive tissues
  • Abstract
  • Introduction
  • Macrophages in the male reproductive tract: Focus on the testis and epididymis
  • Macrophages in the female reproductive tract
  • Macrophages under regulation of sex hormones
  • Conclusions/perspectives
  • References
  • Chapter 12: Macrophages at the maternal-fetal interface
  • Abstract
  • Acknowledgments
  • Introduction
  • Tissue specialization, phenotype, and functional properties of Hofbauer and decidual macrophages
  • Macrophages and their contribution to placental immune privilege in COVID times
  • Conclusions
  • References
  • Chapter 13: Targeting macrophages in systemic diseases
  • Abstract
  • Introduction
  • Distribution of monocytes and their subtypes in the peripheral blood
  • Macrophage subtypes in tissues
  • The role of monocytes and macrophages in systemic autoimmune diseases
  • The role of monocytes and macrophages in systemic vasculitis
  • Macrophage activation syndrome and hyperactive immune syndromes
  • References
  • Index

Product details

  • No. of pages: 322
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: June 8, 2022
  • Imprint: Academic Press
  • eBook ISBN: 9780128213865
  • Paperback ISBN: 9780128213858

About the Editors

Niels Saraiva Camara

Dr. Niels Olson Sairava Camara: Currently full professor of Department of Immunology at the Institute of Biomedical Sciences at the University of São Paulo (since 2011). Visiting Professor at the University of Tours, France in 2006. His laboratory has experience in nephrology area and in cellular and applied immunology, acting on the following topics: kidney transplantation, experimental models of acute and chronic kidney diseases, ischemia and reperfusion injury, regulatory cells and stem cells in kidney diseases. More recently, the laboratory has been studying the microbiota interface, cellular metabolism and inflammation in models of autoimmunity.

Affiliations and Expertise

Professor, Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Brazil

Tárcio Teodoro Braga

Dr. Tárcio Teodoro Braga is currently Professor of Immunology in the Department of Pathology at the Federal University of Parana-UFPR (since 2018). Permanent Professor in the Graduate Courses in Microbiology, Parasitology and Pathology at UFPR and in Biosciences and Biotechnology at the Carlos Chagas Institute, Fiocruz PR. Concluded the Biomedical course at the Federal University of Triângulo Mineiro. He holds a PhD in Sciences from the Department of Immunology of the University of Sao Paulo-USP, with a sandwich period at the University of Maryland and at the University of California, San Francisco. He completed his postdoctoral studies at USP, with an internship at the University of Bonn, Germany, and another postdoctoral fellowship at the Federal University of Sao Paulo. He has experience in the areas of inflammation, fibrosis and innate immunity. His laboratory has expertise in inflammasome, and in the immunology of fibrotic and regenerative processes.

Affiliations and Expertise

Professor, Department of Pathology, Federal University of Parana, Parana, Brazil

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