Macromolecules Regulating Growth and Development

Contributors and Presiding Chairman

Preface

I. Regulatory Factors in the Selective Growth of Mammalian Cells

Role of the Cell Surface in Growth and Transformation

I. Introduction

II. Loss of Density-Dependent Growth Control in Transformed Cells and Cell Surface Alterations

III. Mitosis and Surface Changes during the Cell Cycle of Untransformed Cells in Culture

References

Epidermal Growth Factor: Chemical and Biological Characterization

I. Introduction

II. Chemistry of the Epidermal Growth Factor

III. Biology of the Epidermal Growth Factor

References

Tumor Angiogenesis: Role in Regulation of Tumor Growth

I. Introduction

II. Inhibition of Tumor Growth in the Absence of Angiogenesis

III. Stimulation of Capillary Proliferation by Tumor Occurs at a Distance

IV. Evidence for Humoral Transmission of Tumor Angiogenesis: Tumor Angiogenesis Factor

V. Bioassays for Tumor Angiogenesis Factor

VI. Summary

References

Hormonal Control of Oviduct Growth and Differentiation

I. Introduction

II. Estrogen-Mediated Differentiation

III. The Cell Cycle

IV. Properties of Oviduct Chromatin

V. Messenger RNA Translation

References

II. Formation and Organization of Plant Cell Walls and the Plasma Membrane

Origin and Growth of Cell Surface Components

I. Introduction

II. Origin and Growth of Cell Surface Components in Rapidly Elongating Pollen Tubes

III. Origin and Growth of the Plasma Membrane

IV. Summary

References

The Role of Hydroxyproline-Rich Proteins in the Extracellular Matrix of Plants

I. Introduction

II. Localization of Hydroxyproline

III. Chemistry of Hydroxyproline-Rich Glycoproteins

IV. Ariadne's Thread

References

Synthesis and Secretion of Proteins in Plant Cells: the Hydroxyproline-Rich Glycoprotein of the Cell Wall

I. Introduction

II. Biosynthesis of Peptidylhydroxyproline

III. Glycosylation of Peptidylhydroxyproline

IV. Secretion of the Glycoprotein

V. Characterization of Cell Wall Glycoprotein and Its Cytoplasmic Precursor

VI. Regulation of Cell Wall Protein Synthesis

References

Lipids and Membrane Structure

I. Specificity of Hydrophobic Associations in Lipoproteins

II. Amphipathic Lipids of Membranes

III. Lipid Bilayer Structure in Membranes

IV. Lipid Content of Biological Membranes

V. Specificity of Hydrocarbon Chains Associated with Amphipathic Lipids

VI. Oxidation Resistance of Membrane Lipids

VII. Lipids and Development

VIII. Membrane Models

References

III. Organization and Expression of Genetic Information

Organization of DNA and Proteins in Mammalian Chromosomes

I. Introduction

II. Observations and Interpretation

References

The Multiple Relations of tRNA to Metabolic Control

Text

References

Total Synthesis of Transfer RNA Genes

Text

Biosynthesis of Bacterial Ribosomes

Text

References

The Structural Basis of Selective Gene Expression in Eukaryotes

I. Introduction

II. The Extent of Transcription in Eukaryotic Cells

III. Chemical and Physical Properties of Chromatin

IV. Thermal Denaturation of Chromatin

V. Characterization of DNA in Fractionated Chromatin

VI. Conclusions

VII. Summary

References

Gene Manipulation: Progress and Prospects

I. Introduction

II. Progress with Microbial Systems

III. Possible Applications to Humans

IV. A Current Example

V. Nature of the Problem Posed by Gene Manipulation

VI. Steps Toward a Solution

References

Subject Index