Description

Macromolecular Crystallography, Part B is the"linch-pin"of the ongoing revolution in structural biology. In the past decade, fundamental transformations of nearly every technical aspect of structure determination by X-ray diffraction have taken place. The contributions of this volume and its companion Volume 276 emphasize the revision and extension of statistical tools that underly all phases of structure determination, the practical and conceptual impact of synchrotron radiation, horizon phase-determination methods, and computerized automation.

Key Features

@introbul:Key Features @bul:* Horizon methods for phase determination * Structure building, refinement, and analysis * Analysis of static diffraction patterns and multiple diffraction patterns recorded as a function of time * Accessory software for manipulating, archiving, analyzing, and presenting structures * Documentation of integrated software packages containing the tools needed for structure solution

Readership

Biochemists, biophysicists, analytical chemists, and physical chemists.

Table of Contents

Phases: Horizon Methods: H.A. Hauptman, Shake and Bake: An Algorithm for Automatic Solution ab Initio of Crystal Structures. G. Bricogne, Ab Initio Macromolecular Phasing: A Blueprint for an Expert System Based on Structure Factor Statistics with Built-In Stereochemistry. Model-Independent Map Refinement: F.M.D. Vellieux and R.J. Read, Noncrystallographic Symmetry Averaging in Phase Refinement and Extension. K.Y.J. Zhang, K. Cowtan, and P. Main, Combining Constraints for Electron Density Modification. C.J. Gilmore and G. Bricogne, MICE Computer Program. C.W. Carter and S. Xiany, Phase Improvement Using Conditional Probability Methods: Maximum Entropy Solvent Flattening with Phase Permutation. R.J. Read, Model Phases: Probabilities and Bias. Models: Model Building: S. Fortier, A. Chiverton, J. Glasgow, and L. Leherte, Critical-Point Analysis in Protein Electron-Density Map Interpretation. J.S.Sack and F.A. Quiocho, Chain: A Crystallographic Modeling Program. T.A. Jones and M. Kjeldgaard, Electron Density Map Interpretation. G.J. Kleywegt and T.A. Jones, Model Building and Refinement Practice. B.C. Finsel, LORE: Exploiting Database of Known Structures. Refinement: A.T. Branger and L.M. Rice, Crystallographic Refinement by Simulated Annealing: Methods and Applications. V.S. Lamzin and K.S. Wilson, Automated Refinement for Protein Crystallography. D.E. Tronrud, The TNT Refinement Package. G.M. Sheldrick and T.R. Schneider, SHELXL: High-Resolution Refin

Details

No. of pages:
664
Language:
English
Copyright:
© 1997
Published:
Imprint:
Academic Press
Electronic ISBN:
9780080881157
Print ISBN:
9780121821784

About the serial-volume-editors

Reviews

@from:Praise for the Series @qu:"The Methods in Enzymology series represents the gold-standard." @source:--NEUROSCIENCE @qu:"Incomparably useful." @source:--ANALYTICAL BIOCHEMISTRY @qu:"It is a true 'methods' series, including almost every detail from basic theory to sources of equipment and reagents, with timely documentation provided on each page." @source:--BIO/TECHNOLOGY @qu:"The series has been following the growing, changing and creation of new areas of science. It should be on the shelves of all libraries in the world as a whole collection." @source:--CHEMISTRY IN INDUSTRY @qu:"The appearance of another volume in that excellent series, Methods in Enzymology, is always a cause for appreciation for those who wish to successfully carry out a particular technique or prepare an enzyme or metabolic intermediate without the tiresome prospect of searching through unfamiliar literature and perhaps selecting an unproven method which is not easily reproduced." @source:--AMERICAN SOCIETY OF MICROBIOLOGY NEWS @qu:"If we had some way to find the work most often consulted in the laboratory, it could well be the multi-volume series Methods in Enzymology...a great work." @source:--ENZYMOLOGIA @qu:"A series that has established itself as a definitive reference for biochemists." @source:--JOURNAL OF CHROMATOGRAPHY