Macromolecular Crystallography, Part B is the"linch-pin"of the ongoing revolution in structural biology. In the past decade, fundamental transformations of nearly every technical aspect of structure determination by X-ray diffraction have taken place. The contributions of this volume and its companion Volume 276 emphasize the revision and extension of statistical tools that underly all phases of structure determination, the practical and conceptual impact of synchrotron radiation, horizon phase-determination methods, and computerized automation.

Key Features

@introbul:Key Features @bul:* Horizon methods for phase determination * Structure building, refinement, and analysis * Analysis of static diffraction patterns and multiple diffraction patterns recorded as a function of time * Accessory software for manipulating, archiving, analyzing, and presenting structures * Documentation of integrated software packages containing the tools needed for structure solution


Biochemists, biophysicists, analytical chemists, and physical chemists.

Table of Contents

Phases: Horizon Methods: H.A. Hauptman, Shake and Bake: An Algorithm for Automatic Solution ab Initio of Crystal Structures. G. Bricogne, Ab Initio Macromolecular Phasing: A Blueprint for an Expert System Based on Structure Factor Statistics with Built-In Stereochemistry. Model-Independent Map Refinement: F.M.D. Vellieux and R.J. Read, Noncrystallographic Symmetry Averaging in Phase Refinement and Extension. K.Y.J. Zhang, K. Cowtan, and P. Main, Combining Constraints for Electron Density Modification. C.J. Gilmore and G. Bricogne, MICE Computer Program. C.W. Carter and S. Xiany, Phase Improvement Using Conditional Probability Methods: Maximum Entropy Solvent Flattening with Phase Permutation. R.J. Read, Model Phases: Probabilities and Bias. Models: Model Building: S. Fortier, A. Chiverton, J. Glasgow, and L. Leherte, Critical-Point Analysis in Protein Electron-Density Map Interpretation. J.S.Sack and F.A. Quiocho, Chain: A Crystallographic Modeling Program. T.A. Jones and M. Kjeldgaard, Electron Density Map Interpretation. G.J. Kleywegt and T.A. Jones, Model Building and Refinement Practice. B.C. Finsel, LORE: Exploiting Database of Known Structures. Refinement: A.T. Branger and L.M. Rice, Crystallographic Refinement by Simulated Annealing: Methods and Applications. V.S. Lamzin and K.S. Wilson, Automated Refinement for Protein Crystallography. D.E. Tronrud, The TNT Refinement Package. G.M. Sheldrick and T.R. Schneider, SHELXL: High-Resolution Refin


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© 1997
Academic Press
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