Macrolide Antibiotics - 2nd Edition - ISBN: 9780125264518, 9780080535685

Macrolide Antibiotics

2nd Edition

Chemistry, Biology, and Practice

Editors: Satoshi Omura
eBook ISBN: 9780080535685
Hardcover ISBN: 9780125264518
Imprint: Academic Press
Published Date: 10th June 2002
Page Count: 635
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Macrolide Antibiotics: Chemistry, Biochemistry, and Practice, Second Edition explores the discovery of new macrolide antibiotics, their function, and their clinical use in diseases such as cancer, AIDS, cystic fibrosis and pneumonia. This book discusses the creation of synthetic macrolides and the mechanisms of antibiotic activity. The uses for antimicrobial macrolides in clinical practice are also covered. This book is designed to appeal to both the basic and applied research communities interested in microbiology, bacteriology, and antibiotic/antifungal research and treament.


Researchers in microbiology, bacteriology, and antibiotic/antifungal research and treatment.

Table of Contents



1. Discovery of New Macrolides

I. Introduction

II. Macrolides from Actinomycetes

III. Macrolides from Bacteria Including Myxobacteria

IV. Macrolides from Fungi

V. Macrolides from Plants and Lichens

VI. Macrolides from Insects

VII. Other Macrolides

VIII. Concluding Remarks


2. Discovery of New Macrolides from Marine Organisms

I. Introduction

II. Macrocyclic Lactones of Marine Organism Origin

III. Concluding Remarks


3. Chemical Modification of Macrolides

I. Introduction

II. Fourteen-Membered Macrolides

III. Sixteen-Membered Macrolide Antibiotics and the Avermectin Family

IV. Concluding Remarks


4. Total Synthesis of Macrolides

I. Introduction

II. Synthetic Strategy for Macrolide Synthesis

III. Total Synthesis of Selected Macrolides

IV. Concluding Remarks


5. Biosynthesis, Regulation, and Genetics of Macrolide Production

I. Introduction

II. Reaction Mechanism of Polyketide Biosynthesis

III. Polyketide Synthase

IV. Genes Encoding Modular Polyketide Synthase

V. Sugar Biosynthesis

VI. Genetic Manipulation of PKS Genes


6. Pharmacokinetics and Metabolism of Macrolides

I. Introduction

II. Pharmacokinetics and Metabolism

III. Drug Interaction

IV. Concluding Remarks


7. Antimicrobial Macrolides in Clinical Practice

I. Introduction

II. Fourteen- and Fifteen-Membered Macrolides

III. Sixteen-Membered Macrolides

IV. Concluding Remarks


8. Ivermectin in Clinical Practice

I. Introduction

II. Novel Activity of Ivermectin in Clinical Practice

III. Concluding Remarks


9. Tacrolimus and Other Immunosuppressive Macrolides in Clinical Practice

I. Introduction

II. Tacrolimus, a Brief Developmental History

III. Novel Activity of Tacrolimus and Other Immunosuppressive Macrolides in Clinical Practice

IV. Concluding Remarks


10. Mode of Action and Resistance Mechanisms of Antimicrobial Macrolides

I. Introduction

II. Mode of Action of Macrolide Antibiotics

III. Mechanisms of Resistance to Antimicrobial Macrolides

IV. Important Developments in Macrolide Antibiotics

V. Concluding Remarks

VI. Addendum


11. Mode of Action of Macrolides with Motilin Agonistic Activity--Motilides

I. Introduction

II. Mode of Action of Motilin

III. Invention of Motilides

IV. BiologicalActivity of Motilides

V. Clinical Trials of Motilides

VI. Concluding Remarks


12. Novel Activity of Erythromycin and Its Derivatives

I. Erythromycin Treatment in Diffuse Panbronchiolitis

II. Inhibition of Chloride Channel

III. Effects of Macrolides on Cytokine/Chemokine Expression

IV. Modulation of Bacterial Function

V. New Challenge for Novel Action


13. Mode of Action of Avermectin

I. Introduction

II. Target of Avermectin Action

III. Cloning and Structure of Avermectin Binding Protein

IV. Concluding Remarks


14. Mode of Action of FK506 and Rapamycin

I. Introduction

II. Initial Cellular Target for FK506 and Rapamycin; Peptidyl Prolylcis-trans Isomerases (Rotamases, Immunophilins)

III. Target of FK506-FKBP12 Complex: Calcineurin

IV. Target of Rapamycin-FKBP12 Complex: mTOR/FRAP/RFAT

V. Intervention of Intracellular Signaling Pathways by FK506 and Rapamycin




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© Academic Press 2003
Academic Press
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About the Editor

Satoshi Omura

Affiliations and Expertise

The Kitasato Institute, Tokyo, Japan


"...will be of use to students, clinicians, applied and basic scientists, and physicians. Scientists devoted to the study of secondary metabolites will especially welcome this new coverage of an important group of compounds by a leader in the field." -(2003)

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