Macrolide Antibiotics

2nd Edition

Chemistry, Biology, and Practice

Editors: Satoshi Omura
Hardcover ISBN: 9780125264518
eBook ISBN: 9780080535685
Imprint: Academic Press
Published Date: 10th June 2002
Page Count: 635
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Macrolide Antibiotics: Chemistry, Biochemistry, and Practice, Second Edition explores the discovery of new macrolide antibiotics, their function, and their clinical use in diseases such as cancer, AIDS, cystic fibrosis and pneumonia. This book discusses the creation of synthetic macrolides and the mechanisms of antibiotic activity. The uses for antimicrobial macrolides in clinical practice are also covered. This book is designed to appeal to both the basic and applied research communities interested in microbiology, bacteriology, and antibiotic/antifungal research and treament.


Researchers in microbiology, bacteriology, and antibiotic/antifungal research and treatment.

Table of Contents

Contributors Preface

  1. Discovery of New Macrolides I. Introduction II. Macrolides from Actinomycetes III. Macrolides from Bacteria Including Myxobacteria IV. Macrolides from Fungi V. Macrolides from Plants and Lichens VI. Macrolides from Insects VII. Other Macrolides VIII. Concluding Remarks References
  2. Discovery of New Macrolides from Marine Organisms I. Introduction II. Macrocyclic Lactones of Marine Organism Origin III. Concluding Remarks References
  3. Chemical Modification of Macrolides I. Introduction II. Fourteen-Membered Macrolides III. Sixteen-Membered Macrolide Antibiotics and the Avermectin Family IV. Concluding Remarks References
  4. Total Synthesis of Macrolides I. Introduction II. Synthetic Strategy for Macrolide Synthesis III. Total Synthesis of Selected Macrolides IV. Concluding Remarks References
  5. Biosynthesis, Regulation, and Genetics of Macrolide Production I. Introduction II. Reaction Mechanism of Polyketide Biosynthesis III. Polyketide Synthase IV. Genes Encoding Modular Polyketide Synthase V. Sugar Biosynthesis VI. Genetic Manipulation of PKS Genes References
  6. Pharmacokinetics and Metabolism of Macrolides I. Introduction II. Pharmacokinetics and Metabolism III. Drug Interaction IV. Concluding Remarks References
  7. Antimicrobial Macrolides in Clinical Practice I. Introduction II. Fourteen- and Fifteen-Membered Macrolides III. Sixteen-Membered Macrolides IV. Concluding Remarks References
  8. Ivermectin in Clinical Practice I. Introduction II. Novel Activity of Ivermectin in Clinical Practice III. Concluding Remarks References
  9. Tacrolimus and Other Immunosuppressive Macrolides in Clinical Practice I. Introduction II. Tacrolimus, a Brief Developmental History


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© Academic Press 2003
Academic Press
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About the Editor

Satoshi Omura

Affiliations and Expertise

The Kitasato Institute, Tokyo, Japan


"...will be of use to students, clinicians, applied and basic scientists, and physicians. Scientists devoted to the study of secondary metabolites will especially welcome this new coverage of an important group of compounds by a leader in the field." -(2003)