A Forum for Immunoregulatory Cell Products

1st Edition - December 11, 1987

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  • Editor: Edgar Pick
  • eBook ISBN: 9781483268187

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Lymphokines: A Forum for Immunoregulatory Cell Products, Volume 14, reviews the state of knowledge on lymphokines. The book opens with an integrative view of the role of lymphokines in the generation of fever. It stresses that pirogenicity is the attribute of more than one lymphokine: interleukin 1 (IL-1), interferon α, and tumor necrosis factor (TNF) all possess this quality. This is followed by separate chapters on the chemistry of IL-1 molecules and cloning of the gene for human monocyte IL-1; the production of lymphokine by cells of the central nervous system; the acute phase plasma protein response studied at the level of gene structure and expression; and the involvement of calcium and calcium-linked enzymes in T cell proliferation. Subsequent chapters deal with the involvement of pteridines in T cell activation; the discovery of cachectin and the establishment of its identity with TNF; the effect of IFN-γ and several cytotoxic cytokines on the proliferation, differentiation, and function of normal and leukemic myeloid cells; and the cytotoxic lymphokines produced by effector T cells. The final chapter discusses the ways in which chemically defined changes in cell membranes affect cell division.

Table of Contents

  • Preface

    Interleukins, Tumor Necrosis Factors (Cachectin), and Interferons as Endogenous Pyrogens and Mediators of Fever

    I. Introduction

    II. Background

    III. Fever

    IV. IL-1 as an EP

    V. Tumor Necrosis Factor (Cachectin) as an EP

    VI. Interferons as EPs

    VII. IL-2 as a Pyrogen

    VIII. Assaying for EPs

    IX. Conclusions


    Molecular Biology of Interleukin

    I. Introduction

    II. Molecular Variability

    III. Mapping of the IL-lß Protein Active Site

    IV. IL-lß Gene Structure and Regulation

    V. Speculations and Summary


    Human Interleukin 1 Inhibitors

    I. Introduction

    II. Results

    III. Discussion


    Immunoregulatory Factors Secreted by Astrocytes and Glioblastoma Cells

    I. Introduction

    II. Major Histocompatibility Antigens in the CNS

    III. Interferon-7 Induces la Antigens on Astrocytes

    IV. Antigen Presentation by Astrocytes

    V. Production of IL-1-like Factors by Astrocytes

    VI. Astrocytes Synthesize IL-3-like Factors

    VII. Production of Prostaglandin E by Astrocytes

    VIII. Prostaglandins, IFN-y, and the Expression of MHC Antigens in the Brain

    IX. Glioblastoma Cell-Derived T Cell Suppressor Factor (GTSF)

    X. Conclusion


    Molecular Biology of the Acute Phase Plasma Proteins

    I. Introduction

    II. The Proteins

    III. The Mediators

    IV. Summary


    Contrasting Requirements for IL-2 Production, IL-1 Receptor Expression, and Lymphocyte Proliferation: The Role of Calcium-Dependent and Calcium-Independent Signals

    I. Introduction

    II. IL-2 Production

    III. IL-2 Receptor Expression

    IV. IL-2-IL-2 Receptor Interaction

    V. Multiple Signal Hypothesis

    VI. Regulation of CA2+ Entry into the Cell

    VII. Summary


    Production of Pteridines by T Cells and Macrophages: Modulator Function in Interleukin 2 Signal Transmission

    I. Introduction

    II. Principles of Pteridine Biochemistry and Analysis

    III. Pteridine Production by T Cells and Macrophages In Vitro

    IV. Pteridines as Indicators of T Cell Activation in Clinical Cases

    V. Modulation of IL-2 Response by Pteridines

    VI. Are Pteridines Involved in the Modulation of Other Hormone-Receptor Interactions and in the Communication between the Immune and the Nervous System?

    VII. Addendum


    Cachectin: A Monokine Implicated as a Mediator of Cachexia and Shock

    I. Introduction: The Search for Cachectin

    II. Tumor Necrosis Factor

    III. Isolation and Characterization of Cachectin

    IV. Control of Cachectin Gene Expression

    V. The Role of Cachectin in the Pathogenesis of Fever and Shock

    VI. Other Biological Effects of Cachectin: The List at Present

    VII. The Evolutionary Role of Cachectin

    VIII. Future Prospects


    Studies on the Mode of Action of Tumor Necrosis Factor on Tumor Cells in Vitro

    I. Introduction

    II. Specificity

    III. Receptors

    IV. Kinetics

    V. Morphological Changes on TNF Treatment

    VI. Biochemical Changes on TNF Treatment

    VII. Is TNF an Enzyme?

    VIII. Modification of Tumor Cell Growth and Its Effect on TNF Mediated Cytotoxicity

    IX. Does Free Radical Induction Explain the Cytotoxic Action of TNF?

    X. Summary


    Lymphokine-Like and Interferon Regulatory Activity of Platelet-Derived Growth Factor, Epidermal Growth Factor, and Fibroblast Growth Factor

    I. Introduction

    II. Some Properties of PDGF, EGF, and FGF

    III. Regulation of IFN-7 Production and Other Immune Functions by PDGF, EGF, and FGF

    IV. IFN, PDGF, and Regulation of Oncogene Expression

    V. Summary and Future Directions


    Immune Interferon and Cytotoxins: Regulatory Effects on Myeloid Cells

    I. Introduction

    II. Biology and Interactions of Immune Interferon and Cytotoxins

    III. Regulation of Differentiation-Proliferation of Granulocyte-Monocyte Precursor Cells

    IV. Differentiation of Normal and Leukemia Myeloid Cells

    V. Regulation of Activity of Terminally Differentiated Myelomonocytic Cells

    VI. Summary and Conclusions


    The Cytotoxic Lymphokines Elaborated by Effector T Cells

    I. Introduction

    II. Methods

    III. Results

    IV. Discussion


    Lymphokine-Activated Tumor Inhibition (LATI) in Vivo

    I. Introduction

    II. Tumor-Specific Helper T Lymphocytes

    III. The LATI System

    IV. Host Immune Mechanisms Involved in LATI

    V. From Local to Systemic Reactivity

    VI. The Building Up of a New Immunotherapeutic System


    Immunotoxins and Endocytosis

    I. Introduction

    II. Preparation and Activity of Immunotoxins

    III. Endocytosis and Immunotoxins

    IV. Conclusion


    Heterogeneity of Murine IgG-Binding Factors (IgG-BF): Relation to Major Histocompatibility Complex Class II Antigens

    I. Introduction

    II. Charge Heterogeneity of IgG-BF

    III. Expression of Class II Antigens on T Cell Hybridomas and on IgG-BF


    Involvement of Antigen-Specific T Cell Factors in Regulation of Separate Steps in the Delayed-Type Hypersensitivity Cascade

    I. Introduction: A Cascade of Cellular Interactions Comprises Delayed-Type Hypersensitivity (DTH) and Is Susceptible to Regulation at Different Steps in the Sequence

    II. Regulation of T Cells Producing the Antigen-Specific T Cell Factors (TCF) that Initiate DTH

    III. Regulation of the Late Aspect of DTH by the Early TCFDependent Component of DTH

    IV. Regulation of the Late-Acting, Lymphokine-Producing Lyt-1+2- DTH Effector T Cell

    V. Interplay of Various Factors Involved in the Mediation and Regulation of Delayed-Type Hypersensitivity

    VI. Summary


    Activation of Macrophage C3 Receptors by a Unique Lymphokine

    I. Introduction

    II. Generation of the Lymphokine

    III. Characterization of the Lymphokine

    IV. Mechanism of Action of the Lymphokine

    V. Significance of C3 Receptor Activation and of C3 Receptor-Mediated Phagocytosis in Host Defense


    Control of Cell Division by a Chemically Defined Cell Membrane Modification

    I. Introduction

    II. Production of IL-2 by Periodic Acid

    III. Discussion

    IV. Summary



Product details

  • No. of pages: 488
  • Language: English
  • Copyright: © Academic Press 1987
  • Published: December 11, 1987
  • Imprint: Academic Press
  • eBook ISBN: 9781483268187

About the Editor

Edgar Pick

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