Lupus, An Issue of Rheumatic Disease Clinics of North America

1st Edition, Volume 47-3 - July 6, 2021
Editors: Zahi Touma, Alfred Kim
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 8 3 5 5 6 - 5
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 3 5 5 7 - 2

This issue of Rheumatic Disease Clinics, guest edited by Dr. Alfred Kim and Zahi Touma, will discuss a number of key topics surrounding Lupus. This issue is one of four selected… Read more

Lupus, An Issue of Rheumatic Disease Clinics of North America

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This issue of Rheumatic Disease Clinics, guest edited by Dr. Alfred Kim and Zahi Touma, will discuss a number of key topics surrounding Lupus. This issue is one of four selected each year by series Consulting Editor, Dr. Michael Weisman. Topics discussed in this issue include, but are not limited to: Interferons in SLE, NETosis and neutrophils in SLE, AMP update in lupus nephritis, Patient-reported outcomes, Complement, T cells in SLE, B cells in SLE, Outcome measures for SLE clinical trials, Mitochondrial physiology in SLE, Pregnancy, Lupus cohorts, Innovative trials and new opportunities in SLE, Classification and diagnosis of SLE, and Updates on SLE Treatment.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Foreword
Preface
Interferons in Systemic Lupus Erythematosus
Key points
Introduction
Discussion
Summary
Clinics care points
Disclosure
Neutrophil Dysregulation in the Pathogenesis of Systemic Lupus Erythematosus
Key points
Introduction
Summary
The Power of Systems Biology: Insights on Lupus Nephritis from the Accelerating Medicines Partnership
Key points
Introduction
Single-cell analysis of kidney in lupus nephritis
Urine as a surrogate tissue
Peripheral blood cell analyses
Computational developments
Anticipating the potential of phase 2
Summary
Clinics care points
Patient-Reported Outcomes in Lupus
Key points
Introduction
Patient-reported outcomes to evaluate impact of systemic lupus erythematosus on patient life
Patient-reported outcome tools to evaluate disease severity in systemic lupus erythematosus
Discussion
Clinics care points
T Cells in Systemic Lupus Erythematosus
Key points
Introduction
Overview of T cells and T-helper subsets, and evidence of T-cell dysfunction in systemic lupus erythematosus
T-cell metabolism in systemic lupus erythematosus
Genetics and epigenetics of T cells contributing to systemic lupus erythematosus
T-cell biomarkers and therapeutics in development
Summary
Clinics care points
B Cells in Systemic Lupus Erythematosus: From Disease Mechanisms to Targeted Therapies
Key points
Mechanisms underpinning B cell tolerance breaks in systemic lupus erythematosus
B cell effector functions in systemic lupus erythematosus
B cell–targeted therapies for human lupus
Summary
Clinics care points
Systemic Lupus Erythematosus Outcome Measures for Systemic Lupus Erythematosus Clinical Trials
Key points
Introduction
Primary endpoints in systemic lupus erythematosus randomized controlled trials
Organ-specific outcome measures
Treat to target endpoints: the Lupus Low Disease Activity State
Summary and future work
Clinics care points
Abnormal Mitochondrial Physiology in the Pathogenesis of Systemic Lupus Erythematosus
Key points
Introduction
The role of mitochondria in energy metabolism in health
Abnormal mitochondrial bioenergetics in systemic lupus erythematosus
Mitochondrial oxidative stress in the pathogenesis of systemic lupus erythematosus
Impaired mitochondrial repair in systemic lupus erythematous
Targeting mitochondria in the treatment of systemic lupus erythematosus
Summary
Clinics care points
Management of Pregnancy in Lupus
Key points
Introduction
Peripartum risk
Fetal and neonatal complications
Management and risk factor mitigation
Summary
Clinics care points
Lupus Cohorts
Key points
Types of cohorts
International cohorts
National cohorts
Institutional
Pediatric lupus cohorts
Clinics care points
Innovative Trials and New Opportunities in SLE
Key points
Introduction
Discussion
Summary
Clinics care points
Disclosure
Systemic Lupus Erythematosus Classification and Diagnosis
Key points
Performance characteristics
When do you consider systemic lupus erythematosus?
Antinuclear antibodies
The European League against Rheumatism/American College of Rheumatology criteria rules
Systemic lupus erythematosus organ and serologic manifestations
Summary
Clinics care points
Treatment Update in Systemic Lupus Erythematous
Key points
Introduction
Update on specific pharmacotherapies
Glucocorticoids
Antimalarials
Immunosuppressants
Biologics and targeted therapies
Combination or sequential therapy
Summary/future directions
Clinics care points
Disclosure