Lung Metabolism - 1st Edition - ISBN: 9780123922502, 9780323147415

Lung Metabolism

1st Edition

Proteolysis and Antioproteolysis Biochemical Pharmacology Handling of Bioactive Substances

Editors: Alain Junod
eBook ISBN: 9780323147415
Imprint: Academic Press
Published Date: 1st January 1975
Page Count: 516
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Lung Metabolism: Proteolysis and Antiproteolysis Biochemical Pharmacology Handling of Bioactive Substances focuses on studies on the response of the lung relative to the management of bioactive substances. Divided into three sections with 35 chapters, the book focuses first on proteolysis and antiproteolysis in the lung. Concerns include properties and role of antiproteases; role of leucoproteases in the development of emphysema; and the genetic and clinical considerations of alpha1-antitrypsin deficiencies. The second section focuses on biochemical pharmacology of the lung. Concerns include pulmonary drug-metabolizing enzymes; carrier for oxygen and carbon monoxide in the lung; and metabolism of drugs administered by aerosol. The last section looks at the handling of bioactive substances by the lung. Covered areas include the pharmacokinetic function of the lung; biosynthesis and metabolism of prostaglandins in the lung; and importance and nature of the mechanism of inactivation of prostaglandins in the lung. The book is a vital source of information for readers interested in studying the metabolism of the lung.

Table of Contents

List of Contributors


Section I Proteolysis and Antiproteolysis in the Lung

Properties and Role of Antiproteases

Role of Leucoproteases in the Genesis of Emphysema

Bacterial Proteolytic Enzymes

Mycotic Proteolytic Enzymes

Genetic Considerations on Alpha1-Antitrypsin Deficiency

Clinical Spectrum of Alpha1-Antitrypsin Deficiency

The Antiproteolytic System of the Upper Respiratory Tract

Studies of Alphal-Antitrypsin in Amniotic Fluid, Meconium and Cord Serum of a Homozygote Newborn Infant

Influence of Intravenous Injection of D-Penicillamine and Trasylol® on the Serum Levels of Alpha1-Antitrypsin in Human Subjects

Section II Biochemical Pharmacology of the Lung

Pulmonary Drug-Metabolizing Enzymes

A Specific Carrier for Oxygen and Carbon Monoxide in the Lung

Pulmonary Metabolism of Inhaled Substances and Possible Relationship with Carcinogenicity and Toxicity

Metabolism of Drugs Administered by Aerosol

Mechanisms of Drug Accumulation in the Lung

Hormone Receptors in the Lung

Lung and Coagulation

Drug-Induced Pulmonary Changes

Paraquat Poisoning—Possible Therapeutic Approach

General Discussion

Section III Handling of Bioactive Substances by the Lung

The Pharmacokinetic Function of Lung

Biosynthesis and Metabolism of Prostaglandins in the Lung

Conditions of Release of Prostaglandins from the Lung

Importance and Nature of the Mechanism of Inactivation of Prostaglandins in the Lung

Dipeptidyl Carboxypeptidase in Lung and Blood Plasma

Bradykininase and Converting Enzyme in Lung

Measurement of Prostaglandins E1,E2, and Fα Histamine and Serotonin, Upstream and Downstream the Lung during Pulmonary Vasopressor Response to Hypoxia in Man. Effects of Prostaglandin Synthesis Inhibitors

Mechanism of Uptake of Biogenic Amines in the Pulmonary Circulation

Metabolic Activities of Plasma Membrane and Caveolae of Pulmonary Endothelial Cells, with a Note on Pulmonary Prostaglandin Synthetase

Several Plasma Proteins Demonstrated in Lung Tissue by Immunoelectron Microscopy using the Peroxidase Coupling Technique

Cardiopulmonary Bypass and Conversion of Angiotensin I in Man

Clinical Aspects of Hydrolysis of Vasoactive Peptides in the Pulmonary Circulation

Some Changes in the Lungs Associated with Cardiopulmonary Bypass

Serum Complement Studies during and following Cardiopulmonary Bypass

General Discussion

Concluding Remarks

Author Index

Subject Index


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© Academic Press 1975
Academic Press
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About the Editor

Alain Junod

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