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Loomis's Essentials of Toxicology, Fifth Edition, provides the information on the harmful biologic effects associated with exposures to chemicals of all types. The scope of this book includes a discussion of the major types of chemicals involved, their general properties and detrimental biologic effects, the methods used to demonstrate these effects, the basis for clinical diagnosis, and therapy for the harmful effects of chemicals on humans. Individual examples are used to demonstrate the principle discussed. This reference volume will be an invaluable resource for both toxicologists and graduate and advanced undergraduate students in toxicology and public health.
- Provides a revised and updated edition of one of the "gold" works in the field
- Includes both principles and methods
- Requires minimal background in chemistry and biology
- Expanded Information Sources in Toxicology
Toxicologists and graduate students in toxicology, pharmacology and public health
1. Introduction, Scope, and Principles
2. Numbers in Toxicology
3. Biologic Factors that Influence Toxicity
4. Chemical Factors that Influence Toxicity
5. Influence of Route of Administration on Systemic Toxicity
6. Genetic Factors that Influence Toxicity
7. Classification of Harmful Effects of Chemicals
8. Normal Toxic Effects of Chemicals
9. Abnormal Response to Chemicals
10. The Basis of Selective Toxicity
11. The Basis of Antidotal Therapy
12. Principles of Biological Tests for Toxicity
13. Toxicologic Testing Methods
14. Clinical Toxicology
15. Information Sources in Toxicology
- No. of pages:
- © Academic Press 2019
- 24th October 2019
- Academic Press
- eBook ISBN:
- Paperback ISBN:
Co-Author of Dr. Ted A. Loomis's Essentials of Toxicology, 4th, Dr. Hayes holds degrees from Auburn University (PhD and MS) and Emory University (AB).. Dr. Hayes has held Professorships at the University of Alabama, the University of Mississippi Medical Center and Wake Forest University School of Medicine. Dr. Hayes is a past Secretary-General of IUTOX (two terms), past board member of the American Board of Toxicology, a past president of the American College of Toxicology, the Toxicology Education Foundation, and the Academy of Toxicological Sciences and a past member of the council of the Society of Toxicology. He is currently the Vice President of the Toxicology Forum. Dr. Hayes is a diplomate of the American Board of Toxicology, the Academy of Toxicological Sciences, the American Board of Forensic Medicine, and the American Board of Forensic Examiners. He is a Fellow of the Academy of Toxicological Sciences, the Royal Society of Biology (UK), the American College of Forensic Examiners and the American College of Nutrition. Dr. Hayes is a registered toxicologist in the European Union (ERT) and a certified nutrition specialist (food safety). Dr. Hayes was honored by the Society of Toxicology in 2006 with the Society’s Merit Award, by the Mid-Atlantic Society of Toxicology with its Ambassador Award in 2012, by the American College of Toxicology in 2012 with its Distinguished Scientist Award and by the International Dose-Response Society in 2013 with its Outstanding Leadership Award. Dr. Hayes was named a Distinguished Fellow by the American College of Toxicology in 2013 and a fellow of the American Association for the Advancement of Science in 2014.
University of South Florida College of Public Health
Dr. Wang obtained an MD from Norman Bethune University of Medical Sciences in China, a PhD in Toxicology from University of Louisiana, and is a Diplomat of the American Board of Toxicology. Dr. Wang’s professional experience includes clinical practice in oncology, research on gene regulation in an academic setting, and more than 20 years of professional practice as toxicologist in the pharmaceutical/biotech industry. She is currently the Executive Director of Translational & Development Sciences at Coherus BioSciences, where she oversees preclinical development (in vivo pharmacokinetics, pharmacology and toxicology of small molecules and biologics) of drug candidates from early through late stage development. Prior to joining Coherus, Dr. Wang worked at Novartis Pharmaceuticals and Achaogen, where she led safety assessment efforts for oncology and non-oncology drug development. Dr. Wang received multiple professional awards, recognizing her significant achievements and performance above and beyond work requirements (e.g. Novartis Above & Beyond, Due Diligence, Catalyst Awards, and Spot Awards). She was also acknowledged for outstanding collaboration and contributions on multidisciplinary teams (e.g., Novartis Team Award). Dr. Wang is an active member with Society of Toxicology (SOT), and has contributed to the society’s leadership team as a Councilor and by serving on numerous elected and appointed committees. She also served on the Board of Directors for the American Board of Toxicology (ABT) and is an advisor to the Education Committee at International Union of Toxicology (IUTOX). Dr. Wang is on the Editorial Boards of the International Journal of Toxicology and Toxicology Research and Application. Dr. Wang has taught a course on Practical Toxicology at the University of California at Berkeley as a guest lecturer.
M.D., PhD., D.A.B.T. - Executive Director, Translational & Development Sciences, Coherus BioSciences, Inc.
The Molecular Pathogenesis Group. The group has focused on defining the pathogenesis/carcinogenesis of tumors affecting the reproductive tract of rodents and humans, and assessing the role of environmental and endogenous hormonal factors in the growth of these tumors
DVM, PhD - NIEHS/NTP, Research Triangle Park, NC, USA
Dr. Ted A. Loomis, since receiving his M.D. from Yale University School of Medicine in 1946, he has had a rewarding career in Pharmacology and Toxicology. His career started with an internship at the Marine Hospital, U.S. Public Health Service, Seattle, WA in 1946. By 1953 he as serving as a Captain in the U.S. Army Medical Service. After his military service he eventually became a Professor of Pharmacology and Toxicology at the University of Washington School of Medicine until 1987, and currently is a Consulting Toxicologist. Some of his accomplishments include recipient awards for: Toxicology Education, Toxicology and Forum for Advancement of Toxicology, 1976 and Merit Award, Society of Toxicology, 1986. His professional activities include various committee memberships organizations such as: Tests for Intoxication, National Safety Council, since 1951, Agricultural Advisory Board on Pesticides and Insecticides, State of Washington, 1963-77, and Scientific Review Panel for Health Research, U.S. Environmental Protection Agency, 1980. By 1978, Dr. Loomis had published three editions of Essentials of Toxicology, Lea & Febiger, Philadelphia. He has also been the author or co-author of approximately 100 papers in the scientific literature.
University of Washington School of Medicine, Seattle, U.S.A.
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