This volume covers the current progress in understanding the mechanisms for genomic control of gene expression, which has grown considerably in the last few years as insight into genome organization and chromatin regulation has advanced.

Key Features

* Discusses the evolution of cis-regulatory sequences in drosophila * Includes information on genomic imprinting and imprinting defects in humans *Includes a chapter on epigenetic gene regulation in cancer


Molecular geneticists, clinical geneticists, neurologists, neuroscientists, molecular biologists and biochemists, cell and developmental biologists

Table of Contents

Chromatin Structure and the Regulation of Gene Expression: The Lessons of Pev in Drosophila Polycomb Group Proteins and Long-Range Gene Regulation Evolution of cis-Regulatory Sequences in Drosophila Beta Globin Regulation and Long-Range Interactions Long-Range Regulation of Ą-globin Gene Expression Global Control Regions and Regulatory Landscapes in Vertebrate Development and Evolution Regulation of Imprinting in Clusters: Noncoding RNAs Versus Insulators Genomic Imprinting and Imprinting Defects in Humans Epigenetic Gene Regulation in Cancer Genomic Identification of Regulatory Elements by Evolutionary Sequence Comparison and Functional Analysis Regulatory Variation and Evolution and Implications for Disease Organization of Conserved Elements Near Key Developmental Regulators in Vertebrate Genomes Long-Range Gene Control and Genetic Disease Dirk A. Kleinjan and Laura A. Lettice


No. of pages:
© 2008
Academic Press
eBook ISBN:
Print ISBN:

About the editors

Veronica van Heyningen

Affiliations and Expertise

Veronica van Heyningen []