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Description
This volume covers the current progress in understanding the mechanisms for genomic control of gene expression, which has grown considerably in the last few years as insight into genome organization and chromatin regulation has advanced.
Key Features
* Discusses the evolution of cis-regulatory sequences in drosophila
* Includes information on genomic imprinting and imprinting defects in humans
*Includes a chapter on epigenetic gene regulation in cancer
Readership
Molecular geneticists, clinical geneticists, neurologists, neuroscientists, molecular biologists and biochemists, cell and developmental biologists
Table of Contents
Chromatin Structure and the Regulation of Gene Expression: The Lessons of Pev in Drosophila
Polycomb Group Proteins and Long-Range Gene Regulation
Evolution of cis-Regulatory Sequences in Drosophila
Beta Globin Regulation and Long-Range Interactions
Long-Range Regulation of Ą-globin Gene Expression
Global Control Regions and Regulatory Landscapes in Vertebrate Development and Evolution
Regulation of Imprinting in Clusters: Noncoding RNAs Versus Insulators
Genomic Imprinting and Imprinting Defects in Humans
Epigenetic Gene Regulation in Cancer
Genomic Identification of Regulatory Elements by Evolutionary Sequence Comparison and Functional Analysis
Regulatory Variation and Evolution and Implications for Disease
Organization of Conserved Elements Near Key Developmental Regulators in Vertebrate Genomes
Long-Range Gene Control and Genetic Disease
Dirk A. Kleinjan and Laura A. Lettice
Details
- No. of pages:
- 416
- Language:
- English
- Copyright:
- © 2008
- Published:
- 3rd March 2008
- Imprint:
- Academic Press
- eBook ISBN:
- 9780080877815
- Print ISBN:
- 9780123738813
About the editors
Veronica van Heyningen
Affiliations and Expertise
Veronica van Heyningen [v.vanheyningen@hgu.mrc.ac.uk]