Liquid Chromatography

Liquid Chromatography


3rd Edition - January 1, 2023

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  • Editors: Salvatore Fanali, Bezhan Chankvetadze, Paul Haddad, Colin Poole, Marja-Liisa Riekkola
  • Paperback ISBN: 9780323999694

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Liquid Chromatography: Applications, Third Edition delivers a single source of authoritative information on all aspects of the practice of modern liquid chromatography. The text gives those working in academia and industry the opportunity to learn, refresh, and deepen their understanding of the field by covering basic and advanced theoretical concepts, recognition mechanisms, conventional and advanced instrumentation, method development, data analysis, and more. This third edition addresses new developments in the field with updated chapters from expert researchers. The book is a valuable reference for research scientists, teachers, university students, industry professionals in research and development, and quality control managers.

Key Features

  • Emphasizes the integration of chromatographic methods and sample preparation
  • Provides important data related to complex matrices, sample preparation, and data handling
  • Covers the most interesting and valuable applications in different fields, e.g., proteomic, metabolomics, foodomics, pollutants and contaminants, and drug analysis (forensic, toxicological, pharmaceutical, biomedical)
  • Offers comprehensive updates to all chapters
  • Adds new chapters on selection of liquid chromatographic mode, proteomics, doping analysis, analysis of microplastics, and analysis of pharmaceutically and biologically relevant isoforms


Scientists working in academia/research institutes; teachers and university students from B.Sc. level to PhD level; industry professionals in R&D and quality control managers

Table of Contents

  • 1. Sample preparation for liquid chromatography
    2. Derivatization in liquid chromatography
    3. Basic principles for the selection of liquid chromatographic mode for specific application (new chapter)
    4. Amino acid and bioamine separations
    5. Separation of lipids
    6. Analysis of neurotransmitters and their metabolites by liquid chromatography
    7. Analysis of natural toxins by liquid chromatography
    8. Peptides and Proteins separations
    9. Proteomics (new chapter)
    10. Liquid chromatographic separation of oligonucleotides
    11. Separation of glycans and monosaccharides
    12. Metabolic phenotyping (metabonomics/metabolomics) by liquid chromatography-mass spectrometry
    13. Principles, current applications, and future perspectives of liquid chromatography-mass spectrometry in clinical chemistry
    14. Doping Analysis (new chapter)
    15. Environmental analysis: Atmospheric samples
    16. Environmental analysis: Emerging pollutants
    17. Analysis of Microplastics (new chapter)
    18. Environmental analysis: Persistent organic pollutants
    19. Foodomics: LC and LC-MS-based omics strategies in food science and nutrition
    20. Compositional analysis of foods
    21. Multiresidue methods for pesticides and related contaminants in food
    22. Analysis of vitamins by liquid chromatography
    23. Determination of veterinary drug residues in foods by liquid chromatography-mass spectrometry: Basic and cutting-edge applications
    24. Liquid chromatographic separation of enantiomers
    25. Liquid chromatography in the pharmaceutical industry
    26. Analysis of pharmaceutically and biologically relevant isoforms (new chapter)
    27. Forensic toxicology
    28. Analysis of Natural Products by liquid chromatography
    29. Speciation and element specific detection

Product details

  • No. of pages: 1016
  • Language: English
  • Copyright: © Elsevier 2023
  • Published: January 1, 2023
  • Imprint: Elsevier
  • Paperback ISBN: 9780323999694

About the Editors

Salvatore Fanali

Salvatore Fanali
Salvatore Fanali is Director of Research at the Institute of Chemical Methodologies, Italian National Research Council (C.N.R.) in Monterotondo (Rome), Italy, and head of the Capillary Electromigration and Chromatographic Methods Unit at the same Institute. His research activity is mainly focused on separation science including the development of modern miniaturized techniques (electrodriven and liquid chromatography). He also studies hyphenation with mass spectrometry and development of new stationary phases. Separation methods developed are currently applied to food, pharmaceuticals, chiral environment, and biomedical analysis. He is Editor of the Journal of Chromatography A and a member of the advisory editorial board of seven international scientific journals. Fanali is the author of about 300 publications including some book chapters. He received several awards including the “Liberti Medal” in Separation Science from the Italian Chemical Society.

Affiliations and Expertise

Director and Head, Capillary Electromigration and Chromatographic Methods Unit, Institute of Chemical Methodologies, Italian National Research Council (C.N.R.), Monterotondo, Rome, Italy

Bezhan Chankvetadze

Bezhan Chankvetadze is professor of Analytical Chemistry at Tbilisi State University, Editor of Journal of Pharmaceutical and Biomedical Analysis, and is well recognized in the field of separation science. He is one of the leaders in chromatography and chiral separations with a large number of publications.

Affiliations and Expertise

Professor, Institute of Physical and Analytical Chemistry, School of Exact and Natural Sciences, Tbilisi State University, Tbilisi, Georgia

Paul Haddad

Paul Haddad
Paul Haddad is currently a Distinguished Professor of Chemistry and Australian Research Council Federation Fellow at the University of Tasmania, as well as Director of the Pfizer Analytical Research Centre. He has more than 500 publications in this field and has presented in excess of 450 papers at local and international scientific meetings. He is an editor of Journal of Chromatography A, a contributing editor for Trends in Analytical Chemistry, and was an editor of Analytica Chimica Acta for 6 years. He is currently a member of the editorial boards of 10 other journals of analytical chemistry or separation science. He is the recipient of several national and international awards, including the ACS Award in Chromatography, the Marcel Golay Award, the AJP Martin Gold Medal awarded by the Chromatographic Society, the Royal Society of Chemistry Analytical Separation Methods Award, the RACI HG Smith and Analytical Division medals, and more.

Affiliations and Expertise

Distinguished Professor, School of Chemistry, University of Tasmania, Hobart, Tasmania, Australia

Colin Poole

Colin Poole
Professor Colin Poole is internationally known in the field of thin-layer chromatography and is an editor of the Journal of Chromatography and former editor of the Journal of Planar Chromatography – Modern TLC. He has authored several books on chromatography, recent examples being The Essence of Chromatography published by Elsevier (2003), and Gas Chromatography published by Elsevier (2012). He is the author of approximately 400 research articles, many of which deal with thin-layer chromatography, and is co-chair of the biennial “International Symposium on High-Performance Thin-Layer Chromatography”.

Affiliations and Expertise

Department of Chemistry, Wayne State University, Detroit, MI, USA

Marja-Liisa Riekkola

Marja-Liisa Riekkola is a professor of Analytical Chemistry at Helsinki University, Helsinki, Finland. She is well recognized in the field of separation science. She serves as Editor of Journal of Chromatography A. Prof. Riekkola is one of the leaders in chromatography with a large number of publications.

Affiliations and Expertise

Professor, Laboratory of Analytical Chemistry, Department of Chemistry, University of Helsinki, Finland

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