Lipotropin and Related Peptides - 1st Edition - ISBN: 9780124472051, 9780323159906

Lipotropin and Related Peptides

1st Edition

Editors: Choh Hao Li
eBook ISBN: 9780323159906
Imprint: Academic Press
Published Date: 28th January 1978
Page Count: 218
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Description

Hormonal Proteins and Peptides, Volume V: Lipotropin and Related Peptides deals with peptides that have neurobiological properties.

This book consists of five chapters. Chapter 1 reviews the chemistry of melanotropins, while Chapter 2 describes the most potent morphinelike peptide, ?-endorphin. The third chapter summarizes the chemistry and biology of lipotropins that were discovered and characterized from 1964 to 1965. Chapter 4 examines the properties and physiological role of neurophysins. A historical perspective of the achievements of the Uppsala School regarding the separation methods and biographical sketch of Arne Tiselius are presented at the last chapter.

This book is recommended for endocirnologists, clinicians, and students researching on lipotropins.

Table of Contents


List of Contributors


Preface


Contents of Previous Volumes


1. The Chemistry of Melanotropins


I. Introduction


II. Preparation of Melanotropin Concentrate and Isolation of Porcine β-MSH


III. Isolation of α- and β-Melanotropins from Camel Pituitary Glands


IV. Structure and Synthesis of α-Melanotropin


V. Synthetic Peptides Related to α-Melanotropin


VI. Structure and Synthesis of β-Melanotropins


VII. Structure-Activity Relationships of β-MSH by Synthetic Approach


VIII. Dogfish Melanotropins


IX. Various Studies on β-Melanotropin


X. Inactivation and Activation


XI. Concluding Remarks


References


2. β-Endorphin: A New Biologically Active Peptide from Pituitary Glands


I. Introduction


II. Isolation of β-Endorphin


III. Primary Structure


IV. Synthesis


V. Morphinelike Activity


VI. Development of Tolerance and Physical Dependence


VII. Cross-Tolerance to Morphine


VIII. Experiments in the Cat


IX. Behavioral Activity in Rats


X. Structure-Activity Relationships


XI. Synthesis and Biologic Activity of β-Endorphin Analogs with D-Amino Acids in Residue Positions 1, 2, 4, and 5


XII. Synthesis and Biologic Activity of β-Endorphin Analogs with Shortened Peptide Chains


XIII. Extraanalgesic Activity


XIV. Radioimmunoassay: Dissociation of Opiate Activity and Immunoreactivity


XV. Concluding Remarks


References


3. Lipotropins


I. Introduction


II. Purification


III. Structure Studies


IV. β-MSH Precursor Hypothesis


V. In Vitro Biosynthesis


VI. Pituitary Cells Producing β-LPH


Details

No. of pages:
218
Language:
English
Copyright:
© Academic Press 1978
Published:
Imprint:
Academic Press
eBook ISBN:
9780323159906

About the Editor

Choh Hao Li

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