Lipotropin and Related Peptides

Lipotropin and Related Peptides

1st Edition - January 28, 1978

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  • Editor: Choh Hao Li
  • eBook ISBN: 9780323159906

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Hormonal Proteins and Peptides, Volume V: Lipotropin and Related Peptides deals with peptides that have neurobiological properties. This book consists of five chapters. Chapter 1 reviews the chemistry of melanotropins, while Chapter 2 describes the most potent morphinelike peptide, ?-endorphin. The third chapter summarizes the chemistry and biology of lipotropins that were discovered and characterized from 1964 to 1965. Chapter 4 examines the properties and physiological role of neurophysins. A historical perspective of the achievements of the Uppsala School regarding the separation methods and biographical sketch of Arne Tiselius are presented at the last chapter. This book is recommended for endocirnologists, clinicians, and students researching on lipotropins.

Table of Contents

  • List of Contributors


    Contents of Previous Volumes

    1. The Chemistry of Melanotropins

    I. Introduction

    II. Preparation of Melanotropin Concentrate and Isolation of Porcine β-MSH

    III. Isolation of α- and β-Melanotropins from Camel Pituitary Glands

    IV. Structure and Synthesis of α-Melanotropin

    V. Synthetic Peptides Related to α-Melanotropin

    VI. Structure and Synthesis of β-Melanotropins

    VII. Structure-Activity Relationships of β-MSH by Synthetic Approach

    VIII. Dogfish Melanotropins

    IX. Various Studies on β-Melanotropin

    X. Inactivation and Activation

    XI. Concluding Remarks


    2. β-Endorphin: A New Biologically Active Peptide from Pituitary Glands

    I. Introduction

    II. Isolation of β-Endorphin

    III. Primary Structure

    IV. Synthesis

    V. Morphinelike Activity

    VI. Development of Tolerance and Physical Dependence

    VII. Cross-Tolerance to Morphine

    VIII. Experiments in the Cat

    IX. Behavioral Activity in Rats

    X. Structure-Activity Relationships

    XI. Synthesis and Biologic Activity of β-Endorphin Analogs with D-Amino Acids in Residue Positions 1, 2, 4, and 5

    XII. Synthesis and Biologic Activity of β-Endorphin Analogs with Shortened Peptide Chains

    XIII. Extraanalgesic Activity

    XIV. Radioimmunoassay: Dissociation of Opiate Activity and Immunoreactivity

    XV. Concluding Remarks


    3. Lipotropins

    I. Introduction

    II. Purification

    III. Structure Studies

    IV. β-MSH Precursor Hypothesis

    V. In Vitro Biosynthesis

    VI. Pituitary Cells Producing β-LPH

    VII. Radioimmunoassay

    VIII. Biologic Activities of Lipotropins

    IX. Mechanism of Action of β-LPH at the Cellular Level

    X. Physicochemical Studies of Sheep β-LPH

    XI. Summary and Conclusions

    XII. Addendum


    4. The Neurophysins

    I. The Discovery of the Neurophysins

    II. Properties of the Neurophysins

    III. Isolation and Composition of Neurophysins

    IV. Structure of Neurophysins

    V. Relationship of Hormones and Neurophysins

    VI. Interaction of the Neurophysins with the Neurohypophyseal Hormones

    VII. Measurement of Neurophysins

    VIII. Does Neurophysin Have a Systemic Biologic Role?

    IX. Speculations on the Evolution of Neurophysin


    5. Separation Methods and Arne Tiselius



    Author Index

    Subject Index

Product details

  • No. of pages: 218
  • Language: English
  • Copyright: © Academic Press 1978
  • Published: January 28, 1978
  • Imprint: Academic Press
  • eBook ISBN: 9780323159906

About the Editor

Choh Hao Li

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