Lipoprotein Kinetics and Modeling

Lipoprotein Kinetics and Modeling

1st Edition - January 28, 1982

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  • Editor: Mones Berman
  • eBook ISBN: 9780323147644

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Description

Lipoprotein Kinetics and Modeling contains some of the papers presented at a conference on the analysis and modeling of lipoprotein kinetic data held in Phoenix, Arizona. Contributions from both theorists and experimentalists who attended the conference focus on the developments in the use of mathematical modeling in analyzing the lipoprotein kinetics. The conference highlights the role of kinetic modeling in elucidating the dynamic processes involved in lipoprotein metabolism, the result of improper data analysis that can lead to erroneous physiological interpretations, and the emerging complexities in the lipoprotein system. Organized into six sections comprised of 37 chapters, this book begins with an overview of the theory and applications of kinetic analysis and modeling to lipoproteins. It then discusses the role of kinetic modeling in physiology, the kinetics of apoprotein B in humans, the use of kinetics in investigating the metabolism of very low and intermediate-density lipoproteins, and the models of plasma lipoprotein triglyceride kinetics. It explains the cholesterol kinetics and modeling, the kinetics of high density lipoprotein metabolism in humans, and various techniques for the analysis and modeling of lipoprotein kinetic data such as KABIS (kinetic analysis by interactive simulation) and CONSAM (conversational version of the SAAM modeling program). This book will be of interest to biologists, physiologists, clinical researchers and experts in computer technology and mathematics.

Table of Contents


  • Contributors

    Preface

    A Tribute

    I. Theory

    1 Kinetic Analysis and Modeling: Theory and Applications to Lipoproteins

    I. Physiological Systems and Models

    II. Detailed Mechanistic (Compartmental) Models

    III. Special Mathematical Methods

    IV. Lipoprotein System

    References

    2 The Role of Kinetic Modeling in Physiology

    Text

    References

    II. Apoprotein B

    3 Apoprotein B Kinetics in Man: Concepts and Questions

    I. Experimental Considerations in Modeling ApoB

    II. A 1980 Model of ApoB Metabolism

    III. The Focus on ApoB in the 1980s

    References

    4 Very Low Density Lipoprotein Kinetics in Familial Forms of Hypertriglyceridemia

    I. Introduction

    II. Methods

    III. Results

    IV. Discussion

    References

    5 β-Apolipoprotein Secretion in Man: Investigation by Analysis of 75Se-Labeled Amino Acid Incorporation into Apoprotein

    I. Introduction

    II. Methods

    III. Discussion

    Appendix

    References

    6 The Use of Kinetics in Investigating the Metabolism of Very Low and Intermediate Density Lipoproteins

    I. Introduction

    II. Classification

    III. Methods

    IV. Kinetics

    V. Discussion

    References

    7 Deconvolution Analysis of the Conversion of VLDL Apoprotein B to LDL Apoprotein B

    I. Subjects

    II. Methods

    III. Sample Analysis

    IV. Calculations

    V. Results

    VI. Discussion

    References

    8 Compartmental Models for the Study of Apoprotein B Catabolism in Man

    I. Introduction

    II. Methods

    III. Model Development

    IV. Results

    V. Discussion

    References

    9 Heterogeneity of Low Density Lipoproteins: Kinetic Analysis of Asialated Lipoproteins

    I. Introduction

    II. Methods and Results

    III. Discussion

    References

    10 Molecular and Kinetic Nonidentity of Two Apoprotein B Peptide Classes in Rat Plasma VLDL, IDL, and LDL

    I. Introduction

    II. Experimental

    III. Results and Discussion

    IV. Conclusion

    References

    11 Low Density Lipoprotein Receptor Activity in Man

    I. Introduction

    II. Preparation and Chemical Modification of Labeled LDL

    III. Is Chemically Modified LDL an Appropriate Tracer for the Measurement of Receptor-Independent Catabolism?

    IV. Human Turnover Studies

    V. Receptor-Mediated LDL Catabolism in Normal and FH Subjects

    VI. Effects of Cholestyramine on Receptor-Mediated LDL Catabolism in FH Heterozygotes

    References

    12 Kinetics of Low Density Lipoproteins Labeled with [14C]Sucrose: Theoretical Basis of a Method for Tracing the Sites of Apoprotein Degradation in Vivo

    I. Introduction

    II. Theory of Trapped Labels

    III. A Practical Problem Associated with Trapped Labels

    IV. Results of Computer Simulations [14C]Sucrose-LDL Metabolism

    V. Conclusions

    References

    13 Kinetics of Apolipoprotein B in Normal and Hyperlipidemic Man: Review of Current Data

    I. Turnover of VLDL-ApoB

    II. Turnover of LDL-ApoB (Apo-LDL)

    III. Normal Subjects

    IV. Familial Hypercholesterolemia (FH)

    V. Familial Combined Hyperlipidemia (FCHL) and Familial Hypertriglyceridemia (FHTG)

    VI. Unclassified Hypertriglyceridemia

    References

    14 What Is β-VLDL?

    I. β-VLDL of Familial Dysbetalipoproteinemia

    II. Kinetic Definition of β-VLDL

    III. Small α2-VLDL and IDL

    IV. "Normal" β-VLDL

    V. VLDL "Remnants"

    VI. Intermediate Lipoproteins

    VII. β-VLDL of Cholesterol-Fed Animals

    VIII. Cellular Metabolism of Intermediate Lipoproteins and β-VLDL

    References

    III. Triglycerides

    15 Models of Plasma Lipoprotein Triglyceride Kinetics: A Critical Review

    I. Radiolabeled Precursors

    II. Delipidation Cascade

    III. Potential Information in Phospholipid Turnover Data

    IV. VLDL Synthesis

    V. Importance of Collecting Data for Several Precursors

    VI. Slow Components (“Tails") in VLDL-TG Activity

    VII. A Slow Production Pathway

    VIII. An Alternative to the Slow Production Pathway

    References

    16 A Model of VLDL Metabolism Based on Its Heterogeneity

    I. VLDL-Triglyceride Catabolism in Vivo

    II. VLDL-Triglyceride Production

    III. Model

    References

    17 Triglyceride Exchanges and Transfers: Their Role in the Kinetics of Plasma Triglyceride Transport

    Text

    References

    18 Triglyceride Kinetics: Experimental Problems Related to Modeling

    Text

    References

    19 Are Plasma Triglyceride Concentrations Explained by Saturation Kinetics?

    I. What Are Saturation Kinetics?

    II. What Is the Postulated Role of Saturation Kinetics in the Development of Hypertriglyceridemia?

    III. What Is the Evidence for and against Saturation Kinetics as an Explanation for Hypertriglyceridemia?

    IV. What Constitutes a Removal Defect for VLDL-TG?

    References

    20 Studies of Very Low Density Lipoprotein Triglyceride Metabolism in the Pima Indians

    I. Summary

    II. Introduction

    III. Experimental Methods

    IV. Results and Discussion

    References

    21 HDL Triglyceride Kinetics and Exchanges with VLDL in Vivo

    I. Introduction

    II. Studies

    III. Modeling of Exchange between HDL-TG and VLDL-TG

    IV. Results

    V. Discussion

    References

    IV. Cholesterol

    22 Cholesterol Kinetics and Modeling: Introduction

    Text

    References

    23 A Mathematical Model for Cholesterol Kinetics

    I. Model Development

    II. Cholesterol Models

    III. Model Indeterminacy

    IV. Analysis of Data from Precursor Injection

    V. Analysis of Specific Activity Data Arising from Injection of Labeled Cholesterol

    VI. Analysis of Specific Activity Data Arising from Injection of Labeled Precursor of Cholesterol

    VII. Simplified Sampling Schedule

    VIII. General Model

    IX. Special Problems in Nonlinear Models

    References

    24 Determination of Total Body Cholesterol: Input-Output Analysis versus Compartmental Analysis

    I. General Assumptions

    II. Curve Fitting

    III. Length of Experiment

    IV. Validity of Model

    V. Summary

    References

    25 Cholesterol Disposal in Man: Special Role of HDL Free Cholesterol

    I. Background

    II. Composition of the Bile Acid and Biliary Cholesterol Precursor Pools

    III. Characterization of the Lipoprotein Free Cholesterol Source of Biliary Steroids

    IV. Other Roles of HDL Cholesterol

    References

    26 A Model of Plasma Esterified Cholesterol Metabolism: The Role of Esterified Cholesterol Transfer and Exchanges between Plasma Lipoproteins

    I. Model A

    II. Model B

    References

    27 Role of Isotopes for Determining Absorption of Cholesterol in Man

    I. Percentage Absorption of Isotopic Cholesterol

    II. Mass Absorption of Dietary Cholesterol

    III. Net Mass Absorption of Total Intestinal Cholesterol

    IV. The Issue of Isotopic Exchange

    V. Summary

    References

    V. High Density Apoproteins

    28 The Kinetics of High Density Lipoprotein Metabolism in Man: An Overview

    Text

    References

    29 The Development of a Model for HDL Metabolism: A Strategy in Modeling

    Text

    References

    30 Metabolism of Apolipoproteins A-I and A-II in Man: Methods, Kinetic Models, and Turnover Rates

    I. Methods for Estimation of Turnover of A-I and A-II by Isotopic Techniques

    II. Determination of Specific Activities of A-I and A-II

    III. Kinetic Analysis of Specific Activity Curves of A-I and A-II

    IV. Metabolism of A-I and A-II in Normal Subjects

    V. Hyperlipidemia

    VI. Tangier Disease

    VII. Dietary Perturbation

    References

    31 Apoprotein C Kinetics

    Text

    References

    32 A Possible Interpretation of Apoprotein E Kinetics in Man

    I. Introduction

    II. Results

    References

    VI. Special Techniques

    33 KABIS (Kinetic Analysis by Interactive Simulation)

    Introduction

    References

    34 An Efficient Program for Estimation of Kinetic Parameters in a Model of Very Low Density Lipoprotein Triglyceride Metabolism

    I. Description of the Model

    II. Analytical Solution of the Model

    III. Comparison with Solution by Numerical Integration

    IV. Nonlinear Regression Using the Model

    References

    35 CONSAM (Conversational Version of the SAAM Modeling Program)

    I. Introduction

    II. Structure of CONSAM

    III. CONSAM Commands

    IV. Modeling Tasks Accomplished Using CONSAM

    V. Example of Use of CONSAM in Modeling LDL-B Kinetic Data

    References

    36 A Reduced Model for Very Low Density Lipoprotein Triglyceride Metabolism

    I. Introduction

    II. Methods

    III. Model Development

    IV. Results

    V. Discussion

    Appendix

    References

    37 Sensitivity in Compartmental Models

    I. Sensitivity Theory

    II. Some Sensitivity Identities

    III. Examples

    IV. Summary

    References

    Index






Product details

  • No. of pages: 510
  • Language: English
  • Copyright: © Academic Press 1982
  • Published: January 28, 1982
  • Imprint: Academic Press
  • eBook ISBN: 9780323147644

About the Editor

Mones Berman

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