Lipoprotein (a)

Lipoprotein (a)

1st Edition - January 1, 1990

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  • Editor: Angelo Scanu
  • eBook ISBN: 9780323159449

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Lipoprotein(a) presents the proceedings of the International Symposium, held in Chicago, Illinois, on December 2–3, 1988. It discusses the different aspects of the research on lipoprotein(a), commonly referred to as Lp(a). It covers a wide range of topics, including comparative biology, metabolism, structure, epidemiology, and treatment. Comprised of 15 chapters, the book starts with an overview of the role of Lp(a) in atherosclerotic cardiovascular disease (ASCVD), followed by a discussion on recent findings and developments. It then considers the relationship between elevated plasma Lp(a) and the inherited risk factor for the development of coronary heart disease. The reader is also introduced to the various components of Lp(a), which include neutral lipids, polar lipids, apoprotein(a), and apoprotein B. Other chapters discuss the specific functions of apolipoproteins in plasma lipid metabolism, which determine the fate of the various lipoprotein particles in plasma. This book will be of benefit to cardiologists and medical practitioners.

Table of Contents

  • Preface

    Chapter 1 Lp(a) Lipoprotein: An Overview

    I. Introduction

    II. Background

    III. The Early Years

    IV. Lp(a) Lipoprotein and Coronary Heart Disease

    V. Concluding Remarks


    Chapter 2 Molecular Biology of Apolipoprotein(a)

    I. Introduction

    II. Structure of Apolipoprotein(a)

    III. Sites of Apo(a) Synthesis

    IV. Function of Apo(a)

    V. Evolution and Genetics of Apo(a)


    Chapter 3 Heterogeneity of Particles Containing the Apo B-Apo(a) Complex

    I. Introduction

    II. Amounts of Apo B-Apo(a) in Plasma

    III. Apo B-Apo(a) Heterogeneity

    IV. Conclusion


    Chapter 4 Structural Properties of Apo(a): A Major Apoprotein of Human Lipoprotein(a)

    I. Background

    II. Polymorphism of Apo(a)

    III. Primary Structure of an Apo(a) Polymorph

    IV. Secondary Structure of an Apo(a) Polymorph

    V. Conclusions


    Chapter 5 Genetics of the Lp(a) Lipoprotein

    I. Introduction

    II. Structure of the Lp(a) Lipoprotein

    III. Genetics of Lp(a) Lipoprotein

    IV. Apo(a) Types and Lp(a) Levels

    V. Linkage of Apo(a) and Plasminogen

    VI. Apo(a) Types and Levels in Familial Hypercholesteremia


    Chapter 6 The Structure and Activation of Human Plasminogen

    I. Structure of Human Plasminogen

    II. Function of the Kringle Regions

    III. Activation of Human Plasminogen

    IV. Homology of Apo(a) with Human Plasminogen


    Chapter 7 Lp(a) and the Fibrinolytic System

    I. Atherosclerosis and Thrombosis: Interactive Mechanisms

    II. Atherosclerosis and Thrombosis: Epidemiologie Associations

    III. Structural Homologies in Lp(a) and Potential Influence on Fibrinolysis

    IV. Effects of Lp(a) on Fibrinolysis

    V. Clinical Implications and Future Directions


    Chapter 8 Relationship between Plasminogen Receptors and Lp(a)

    I. Introduction

    II. Plasminogen Binding Sites: High Density Receptors with Wide Cellular Distribution

    III. Functions of Plasminogen Receptors

    IV. The Recognition Specificity of Plasminogen Receptors

    V. Interaction of Lp(a) with Plasminogen Receptors

    VI. Concluding Remarks


    Chapter 9 Lipoprotein(a) and Plasminogen: Linkage Analysis

    I. Introduction

    II. Methods

    III. Results

    IV. Discussion


    Chapter 10 The Measurement of Lp(a) and Its Clinical Application

    I. Measurement of Lp(a) Lipoprotein in Biological Fluids

    II. Effect of Diet and Drugs on Lp(a) Levels

    III. Genetics of Lp(a)

    IV. Lp(a) and Coronary Heart Disease


    Chapter 11 Incidence of Lp(a) among Populations

    I. Introduction

    II. Incidence of Lp(a) Lipoprotein in Randomly Selected Reference Populations

    III. Incidence of Lp(a) Lipoprotein in Selected Populations with Atherosclerotic Disorders

    IV. Lp(a) Lipoprotein in Acute Phase Reactions

    V. Lp(a) Lipoprotein in Relation to Other Risk Factors

    VI. Environmental Effects on Inherited Lp(a) Lipoprotein Levels

    VII. Paradoxes in Lp(a) Lipoprotein Research

    VIII. Concluding Remarks


    Chapter 12 The Rhesus Monkey as a Model for the Study of Lp(a)

    I. Introduction

    II. Rhesus Monkey Model of Familial Hypercholesteremia

    III. Characteristics of Plasma Lp(a) in the Members of the Rhesus Monkey Family with a Spontaneous Hypercholesteremia

    IV. General Comments

    V. Conclusions


    Chapter 13 The Physiological Role of Lp(a)

    I. Introduction

    II. Lp(a) Structure and Composition

    III. Metabolism of Lp(a)

    IV. Binding Studies of Lp(a) to Cultured Cells

    V. Influence of Plasma Lp(a) Concentrations by Diet and Drugs

    VI. The Atherogenicity of Lp(a)

    VII. Summary and Conclusion


    Chapter 14 Lipoprotein(a) in PROCAM Participants and Young Myocardial Infarction Survivors

    I. Introduction

    II. Lp(a) in Young Male MI Survivors

    III. Lp(a) in PROCAM Study Participants

    IV. Conclusions

    Chapter 15 Effectiveness of Diet and Drugs in the Treatment of Patients with Elevated Lp(a) Levels

    I. Introduction

    II. Diet

    III. Drug Treatment

    IV. Summary



Product details

  • No. of pages: 238
  • Language: English
  • Copyright: © Academic Press 1990
  • Published: January 1, 1990
  • Imprint: Academic Press
  • eBook ISBN: 9780323159449

About the Editor

Angelo Scanu

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