Lipoprotein (a)

1st Edition - January 1, 1990
Editor: Angelo Scanu
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 5 9 4 4 - 9

Lipoprotein(a) presents the proceedings of the International Symposium, held in Chicago, Illinois, on December 2–3, 1988. It discusses the different aspects of the research on… Read more

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Lipoprotein(a) presents the proceedings of the International Symposium, held in Chicago, Illinois, on December 2–3, 1988. It discusses the different aspects of the research on lipoprotein(a), commonly referred to as Lp(a). It covers a wide range of topics, including comparative biology, metabolism, structure, epidemiology, and treatment. Comprised of 15 chapters, the book starts with an overview of the role of Lp(a) in atherosclerotic cardiovascular disease (ASCVD), followed by a discussion on recent findings and developments. It then considers the relationship between elevated plasma Lp(a) and the inherited risk factor for the development of coronary heart disease. The reader is also introduced to the various components of Lp(a), which include neutral lipids, polar lipids, apoprotein(a), and apoprotein B. Other chapters discuss the specific functions of apolipoproteins in plasma lipid metabolism, which determine the fate of the various lipoprotein particles in plasma. This book will be of benefit to cardiologists and medical practitioners.

PrefaceChapter 1 Lp(a) Lipoprotein: An Overview I. Introduction II. Background III. The Early Years IV. Lp(a) Lipoprotein and Coronary Heart Disease V. Concluding Remarks ReferencesChapter 2 Molecular Biology of Apolipoprotein(a) I. Introduction II. Structure of Apolipoprotein(a) III. Sites of Apo(a) Synthesis IV. Function of Apo(a) V. Evolution and Genetics of Apo(a) ReferencesChapter 3 Heterogeneity of Particles Containing the Apo B-Apo(a) Complex I. Introduction II. Amounts of Apo B-Apo(a) in Plasma III. Apo B-Apo(a) Heterogeneity IV. Conclusion ReferencesChapter 4 Structural Properties of Apo(a): A Major Apoprotein of Human Lipoprotein(a) I. Background II. Polymorphism of Apo(a) III. Primary Structure of an Apo(a) Polymorph IV. Secondary Structure of an Apo(a) Polymorph V. Conclusions ReferencesChapter 5 Genetics of the Lp(a) Lipoprotein I. Introduction II. Structure of the Lp(a) Lipoprotein III. Genetics of Lp(a) Lipoprotein IV. Apo(a) Types and Lp(a) Levels V. Linkage of Apo(a) and Plasminogen VI. Apo(a) Types and Levels in Familial Hypercholesteremia ReferencesChapter 6 The Structure and Activation of Human Plasminogen I. Structure of Human Plasminogen II. Function of the Kringle Regions III. Activation of Human Plasminogen IV. Homology of Apo(a) with Human Plasminogen ReferencesChapter 7 Lp(a) and the Fibrinolytic System I. Atherosclerosis and Thrombosis: Interactive Mechanisms II. Atherosclerosis and Thrombosis: Epidemiologie Associations III. Structural Homologies in Lp(a) and Potential Influence on Fibrinolysis IV. Effects of Lp(a) on Fibrinolysis V. Clinical Implications and Future Directions ReferencesChapter 8 Relationship between Plasminogen Receptors and Lp(a) I. Introduction II. Plasminogen Binding Sites: High Density Receptors with Wide Cellular Distribution III. Functions of Plasminogen Receptors IV. The Recognition Specificity of Plasminogen Receptors V. Interaction of Lp(a) with Plasminogen Receptors VI. Concluding Remarks ReferencesChapter 9 Lipoprotein(a) and Plasminogen: Linkage Analysis I. Introduction II. Methods III. Results IV. Discussion ReferencesChapter 10 The Measurement of Lp(a) and Its Clinical Application I. Measurement of Lp(a) Lipoprotein in Biological Fluids II. Effect of Diet and Drugs on Lp(a) Levels III. Genetics of Lp(a) IV. Lp(a) and Coronary Heart Disease ReferencesChapter 11 Incidence of Lp(a) among Populations I. Introduction II. Incidence of Lp(a) Lipoprotein in Randomly Selected Reference Populations III. Incidence of Lp(a) Lipoprotein in Selected Populations with Atherosclerotic Disorders IV. Lp(a) Lipoprotein in Acute Phase Reactions V. Lp(a) Lipoprotein in Relation to Other Risk Factors VI. Environmental Effects on Inherited Lp(a) Lipoprotein Levels VII. Paradoxes in Lp(a) Lipoprotein Research VIII. Concluding Remarks ReferencesChapter 12 The Rhesus Monkey as a Model for the Study of Lp(a) I. Introduction II. Rhesus Monkey Model of Familial Hypercholesteremia III. Characteristics of Plasma Lp(a) in the Members of the Rhesus Monkey Family with a Spontaneous Hypercholesteremia IV. General Comments V. Conclusions ReferencesChapter 13 The Physiological Role of Lp(a) I. Introduction II. Lp(a) Structure and Composition III. Metabolism of Lp(a) IV. Binding Studies of Lp(a) to Cultured Cells V. Influence of Plasma Lp(a) Concentrations by Diet and Drugs VI. The Atherogenicity of Lp(a) VII. Summary and Conclusion ReferencesChapter 14 Lipoprotein(a) in PROCAM Participants and Young Myocardial Infarction Survivors I. Introduction II. Lp(a) in Young Male MI Survivors III. Lp(a) in PROCAM Study Participants IV. ConclusionsChapter 15 Effectiveness of Diet and Drugs in the Treatment of Patients with Elevated Lp(a) Levels I. Introduction II. Diet III. Drug Treatment IV. Summary ReferencesIndex