Lipid Signaling and Metabolism

Lipid Signaling and Metabolism

1st Edition - August 9, 2020

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  • Editor: James Ntambi
  • eBook ISBN: 9780128194058
  • Paperback ISBN: 9780128194041

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Lipid Signaling and Metabolism provides foundational knowledge and methods to examine lipid metabolism and bioactive lipid signaling mediators that regulate a broad spectrum of biological processes and disease states. Here, world-renowned investigators offer a basic examination of general lipid, metabolism, intracellular lipid storage and utilization that is followed by an in-depth discussion of lipid signaling and metabolism across disease areas, including obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders. Throughout, authors demonstrate how expanding our understanding of lipid mediators in metabolism and signaling enables opportunities for novel therapeutics. Emphasis is placed on bioactive lipid metabolism and research that has been impacted by new technologies and their new potential to transform precision medicine.

Key Features

  • Provides a clear, up-to-date understanding of lipid signaling and metabolism and the impact of recent technologies critical to advancing new studies
  • Empowers researchers to examine bioactive lipid signaling and metabolism, supporting translation to clinical care and precision medicine
  • Discusses the role of lipid signaling and metabolism in obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders, among others


Active researchers in biochemistry, molecular biology, nutrition, endocrinology, cell biology, gastroenterology, and pharmacology; clinician scientists

Table of Contents

  • 1. Homeostatic Control of Membrane Lipid Biosynthesis in Bacteria
    Diego de Mendoza
    2. Lipid trafficking and signaling in plants
    Christoph Benning
    3. Sex as a modulator of lipid metabolism and metabolic disease
    Karen Reue
    4. Local interactions in the bone marrow microenvironment and their contribution to system metabolic processes
    Ormond MacDougald
    5. Lipids in the Transcriptional Regulation of Adipocyte Differentiation and Metabolism
    Qi-Qun Tang
    6. Lipid receptors and signaling in adipose tissue
    David Bernlohr
    7. Adipocyte lipolysis and lipid derived metabolite signaling
    Judith Simcox
    8. Regulation of Intracellular Lipid Storage and Utilization
    Kimberly Buhman
    9. The lipid droplet as a signaling node
    Doug Gene Mashek
    10. Lipid droplets in the immune response and beyond
    Sheetal Gandotra
    11. Fatty acids mediators and the inflammasome
    Catherine Mounier
    12. Identification and pathophysiological roles of LTB4 receptors BLT1 and BLT2
    Takehiko Yokomizo
    13. The Forkhead Box O family in Insulin Action and Lipid Metabolism
    H. Henry Dong
    14. Interplays between nutritional and inflammatory signaling and fat metabolism in pathophysiology of NAFLD
    Chaodong Wu
    15. Endocannabinoids: The Lipid Effectors of Metabolic Regulation in Health and Disease
    Joseph Tam
    16. Gut Microbiota Interaction in Host Lipid Metabolism
    Matam Vijay-Kumar (Vijay)
    17. Insights into the metabolism of lipids in Obesity and Diabetes
    Emmanuel Mukwevho and James M. Ntambi
    18. Lipid metabolic features of skeletal muscle in pathological and physiological conditions
    Chad M. Paton
    19. Sphingolipid mediators of cell signaling and metabolism
    Agnieszka Dobrzyn
    20. Role of bile acid receptors in the regulation of cardiovascular diseases
    Makoto Miyazaki
    21. Molecular Mechanisms Underlying Effects of n-3 and n-6 Fatty Acids in Cardiovascular Diseases
    Richard J. Deckelbaum
    22. Lipid metabolism and signaling in Cancer
    Antonio Moschetta
    23. Altered lipid metabolic homeostasis in Alzheimer’s disease
    Anthony Don
    24. Role of Xenosterols in Health and Disease
    Babunageswararao Kanuri and Shailendra Patel
    25. Adipose Tissue Development and Metabolic Regulation
    Hei Sook Sul

Product details

  • No. of pages: 566
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: August 9, 2020
  • Imprint: Academic Press
  • eBook ISBN: 9780128194058
  • Paperback ISBN: 9780128194041

About the Editor

James Ntambi

Dr. James M. Ntambi is Professor of Biochemistry and the Steenbock Professor of Nutritional Sciences, at the University of Wisconsin-Madison, as well as Adjunct Professor of Biological Chemistry at Johns Hopkins University School of Medicine. The focus of Dr. Ntambi's research is to understand the genetic regulation of metabolism, adipocyte biology, and differentiation. He is specifically interested in the genetic basis of obesity, cardiovascular disease, insulin resistance, diabetes and fatty live disease and how dietary factors, hormones, and environmental factors influence these disease states. Most recently, his team have genetically engineered mice that are born without the stearoyl-CoA desaturase gene-1, and found that these mice resist obesity, diabetes, and fatty liver disease. Dr. Ntambi also conducts research on obesity and diabetes and other non-communicable metabolic diseases in developing countries. He has set up the Lweza-Mukono Community Health Initiatives Inc. ( a registered organization operating as a center of excellence in Lweza village Mukono District, Uganda implementing projects linking health to agriculture, nutrition and education to address, prevent, delay and manage the non-communicable metabolic diseases referred to above. Dr. Ntambi has published more than 200 scientific articles in such journals as Cell Metabolism, JBC, Journal of Lipid research, PNAS, JCI, Scientific Reports, PLoS ONE, BBRC, Gastroenterology, and Journal of Hepatology.

Affiliations and Expertise

Professor of Biochemistry, Steenbock Professor of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA

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