Lipid Pharmacology

Lipid Pharmacology

1st Edition - January 1, 1976

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  • Editor: Rodlfo Paoletti
  • eBook ISBN: 9780323155113

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Medicinal Chemistry: Lipid Pharmacology, Volume 2 focuses on the effects of drugs on lipid metabolism. This book explores the methodology in lipid chemistry by which transport and release mechanisms can be investigated very effectively by the use of drugs. Organized into 12 chapters, this book starts with an overview of the total lipid fraction that can be isolated from tissues by any one of many solvent extraction procedures. This text then defines atherosclerosis disease and explores the studies in experimental atherosclerosis, which are designed to better understand the progression of this disease in humans. Other chapters discuss the inhibitors of cholesterol biosynthesis and examine the pathways involved in the synthesis of other classes of lipids. This book describes as well all drugs known to influence steroid metabolism in humans and other mammals. The final chapter deals with the biological activity of a substance, which is determined by several factors. Chemists, biochemists, and pharmacologists will find this book extremely useful.

Table of Contents

  • Contributors


    Chapter 1 Methods for the Study of Lipid Changes in Biological Experiments

    I. Isolation of Lipids from Tissue

    II. Separation of Lipid Classes

    III. Chemical Methods for Class Determinations

    IV. Gas Chromatography Procedures

    V. Special Instrumental Methods

    VI. Radioactivity Measurements


    Chapter 2 Experimental Atherosclerosis

    I. Introduction

    II. Definition of Atherosclerosis

    III. Grading of Atherosclerosis

    IV. General Considerations

    V. Experimental Atherosclerosis in Different Animal Species

    VI. Epilogue


    Chapter 3 Drugs Affecting Lipid Synthesis

    I. Introduction

    II. Theoretical Considerations

    III. α-Phenylbutyric Acid and Related Compounds

    IV. Derivatives of Dimethyl- or Diethylaminoethanol

    V. Benzmalecene

    VI. Steroids

    VII. Nicotinic Acid

    VIII. Vanadium

    IX. Analogs of Mevalonic Acid

    X. Terpenes

    XI. Inhibitor of Cholesterol Synthesis (I.C.S.)

    XII. 1-p-Chlorophenylpentylsuccinate

    XIII. Psychotropic Drugs


    Chapter 4 Drugs, Hormones, and Other Factors Influencing Steroid and Sterol Metabolism

    I. Introduction

    II. Steroid Pharmacology

    III. Methods of Investigation

    IV. Physiological Control of Steroid and Sterol Metabolism

    V. Some Factors Influencing Steroid and Sterol Transformations in Animal Tissues

    VI. Drugs Inhibiting Steroid Biogenesis in the Adrenal Cortex

    VII. Drugs and Hormones Influencing Cholesterol Catabolism

    VIII. Concluding Remarks


    Chapter 5 Essential Fatty Acids

    I. Definition and History

    II. Chemistry

    III. Occurrence

    IV. Metabolism

    V. Function

    VI. Dietary Requirement


    Chapter 6 Nicotinic Acid and Derivatives

    I. Historical Introduction

    II. The Effect of Nicotinic Acid Administration on Serum Lipids of Experimental Animals

    III. The Effect of Nicotinic Acid Administration on Serum Lipids in Man

    IV. The Effect of the Administration of Large Oral Doses of Nicotinic Acid on Metabolism Other Than Lipid Metabolism

    V. The Effect of Compounds Related to Nicotinic Acid on Lipid Metabolism

    VI. The Mechanism of Action of Nicotinic Acid in Lowering Blood Lipids


    Chapter 7 The Thyroid and Lipid Metabolism

    I. Introduction

    II. The Influence of the Thyroid on Cholesterol Metabolism

    III. The Influence of the Thyroid on the Metabolism of Lipids Other Than Cholesterol


    Chapter 8 Gonadal Hormones and Lipid Metabolism

    I. Introduction

    II. Sex Differences in Incidences of Atherosclerosis and Related Mortality

    III. Sex Differences in the Concentration and Distribution of Circulating Lipids

    IV. Serum Lipids in the Hypogonadal State

    V. Influence of Exogenous Gonadal Hormones on Circulating Lipids and Mortality

    VI. Sex and Gonadal Hormone Influences on Circulating Lipids and Atherosclerosis in Animals

    VII. Influence of Gonadal Hormones on Lipid Synthesis

    VIII. Summary


    Chapter 9 Catecholamines

    I. Introduction

    II. Effects of Catecholamines in the Intact Animal on the Concentration of Lipids in Blood Plasma and Tissues

    III. The Action of Catecholamines in Adipose Tissue

    IV. The Role of Catecholamines and the Sympathetic Nervous System in the Physiological Regulation of Fat Metabolism

    V. Summary


    Chapter 10 Herapin, Heparinoids, and The Clearing Factor

    I. Introduction

    II. The Clearing Factor

    III. Endogenous and Tissue Clearing Factor

    IV. Clearing Factor Inhibitors

    V. Role of Clearing Factor

    VI. Toxicology of Heparinoids

    VII. Absorption of Heparin and Heparinoids from Gastrointestinal Tract


    Chapter 11 Drugs Acting on Lipid Catabolism and Excretion

    I. Introduction

    II. Essential Physiological Data Regarding the Catabolism and the Excretion of Cholesterol

    III. Pharmacological Actions on the Catabolism and Excretion of Cholesterol

    IV. Essential Physiological Data Regarding the Catabolism and the Excretion of Lipids Other Than Cholesterol

    V. Pharmacological Actions on the Catabolism and on the Excretion of Lipids Other Than Cholesterol


    Chapter 12 The Metabolism and Dispositionof Hypocholesteremic Drugs

    I. Introduction

    II. Carboxylic Acids

    III. Derivatives of β-Diethylaminoethanol

    IV. The Iodothyronines

    V. Metabolism of Specific Iodothyronines


    Author Index

    Subject Index

Product details

  • No. of pages: 342
  • Language: English
  • Copyright: © Academic Press 1976
  • Published: January 1, 1976
  • Imprint: Academic Press
  • eBook ISBN: 9780323155113

About the Editor

Rodlfo Paoletti

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