Lipid-Based Nanocarriers for Drug Delivery and Diagnosis - 1st Edition - ISBN: 9780323527293

Lipid-Based Nanocarriers for Drug Delivery and Diagnosis

1st Edition

Authors: Muhammad Raza Shah Muhammad Imran Shafi Ullah
Paperback ISBN: 9780323527293
Imprint: William Andrew
Published Date: 15th June 2017
Page Count: 316
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Table of Contents

1. Solid Lipid Nanoparticles
2. Nanostructured Lipid Carriers
3. Nanostructured Lipid Carriers
4. Nanoemulsions
5. Nanosuspensions
6. Lipid Nanotubes
7. Ultrasound-Responsive Nanosystems
8. Liposomes for Targeted Drug Delivery in Cancer Therapy
9. Lipid-Based Nanocarriers for Cancer Gene Therapy
10. pH and Temperature Responsive Nanosystems
11. Niosomal Drug Delivery


Description

In the drug discovery process, it is estimated that approximately 10,000 chemical entities need to be tested before one would eventually reach the consumer market. Major reasons for this high failure rate are drug toxicity, low bioavailability, biological degradation and inadvertent intrinsic side effects. Nanotechnology is exponentially expanding in the area of medicines, therapeutics, diagnostics and drug delivery.

A delivery system is a formulation or a device that introduces bioactive compounds into the body and improves their efficacy and safety by controlling the rate and targeted release of the bioactive compound. Among the colloidal vectors proposed for the controlled delivery and targeting of drugs and other biologically active compounds, lipid-based nanocarriers has acquired an increasing role due to a number of peculiar technological and physical features. These carriers are generally composed of physiological lipids well tolerated by human body. The potential advantages of lipid-based nanocarriers application over other carriers are of their high biocompatibility, higher drug loading capacity and scalability.

This book explores the present state of widely used lipid-based nanoparticulate delivery systems such as solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), nanoliposomes, micelles, nanoemulsions, nanosuspensions and lipid nanotubes. The various types of lipids that can be exploited for drug delivery and their chemical composition and physicochemical characteristics are reviewed in detail. The characterization aspects and effects of their dimensions on drug delivery systems behaviour in in-vitro and in-vivo are also described. The book covers the effective utilization of these lipids based systems for controlled and targeted delivery of potential drugs/ genes for enhanced clinical efficacy. The role of lipid nanocarriers in Nanomedicine, diagnostic and therapy is also covered.

Key Features

  • Explores the present state of widely used lipid-based nanoparticulate delivery systems
  • Explores how lipid-based nanocarriers improves drug delivery safety
  • Describes the nanoformulation design, the preparation methods of lipid-based nanocarriers

Readership

Researchers and bioengineers working in the areas of nanomedicine and drug delivery


Details

No. of pages:
316
Language:
English
Copyright:
© William Andrew 2017
Published:
Imprint:
William Andrew
Paperback ISBN:
9780323527293

About the Authors

Muhammad Raza Shah Author

Muhammad Raza Shah is a Professor at the International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University of Karachi, Pakistan. He is also the Head of the Center for Bioequivalence Studies and Clinical Research (CBSCR) and the recipient of numerous awards, including the civil award Tamgha-i-Imtiaz from President of Pakistan, and the Dr. M. Raziuddin Siddiqi Prize (2015) for Scientists under 40 in the Field of Chemistry by Pakistan Academy of Sciences. He has written over 200 peer-reviewed journal papers.

Affiliations and Expertise

Associate Professor, International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University, Karachi, Pakistan

Muhammad Imran Author

Muhammad Imran is a graduate student and based at the International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University of Karachi, Pakistan.

Affiliations and Expertise

International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan

Shafi Ullah Author

Shafi Ullah is a graduate student and based at the International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University of Karachi, Pakistan.

Affiliations and Expertise

International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan