Linkage Thermodynamics of Macromolecular Interactions - 1st Edition - ISBN: 9780120342518, 9780080582245

Linkage Thermodynamics of Macromolecular Interactions, Volume 51

1st Edition

Serial Editors: Frederic Richards David Eisenberg Peter Kim
Serial Volume Editors: Enrico Di Cera
eBook ISBN: 9780080582245
Hardcover ISBN: 9780120342518
Imprint: Academic Press
Published Date: 20th May 1998
Page Count: 473
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Table of Contents

M. Schaefer, H. van Vlijmen, and M. Karplus, Electrostatic Contributions to Molecular Free Energies in Solution.

E. Di Cera, Site-Specific Analysis of Mutational Effects in Proteins.

S.J. Edelstein and J.-P. Changeux, Allosteric Transitions of the Acetylcholine Receptor.

G.K. Ackers, Deciphering the Molecular Code of Hemoglobin Allostery.

E. Freire, Statistical Thermodynamic Linkage between Conformational and Binding Equilibria.

M.T. Record, Jr., W. Zhang, and C.F. Anderson, Analysis of the Effects of Salts and Uncharged Solutes on Protein and Nucleic Acid Equilibria and Processes: A Practical Guide to Recognizing and Interpreting Polyelectrolyte Effects, Hofmeister Effects, and Osmotic Effects of Salts.

S.N. Timasheff, Control of Protein Stability and Reactions by Weakly Interacting Cosolvents: The Simplicity of the Complicated. Author Index. Subject Index.


Description

This volume commemorates the 50th anniversary of the appearance in Volume 4 in 1948 of Dr. Jeffries Wyman's famous paper in which he "laid down" the foundations of linkage thermodynamics. Experts in this area contribute articles on the state-of-the-art of this important field and on new developments of the original theory. Among the topics covered in this volume are electrostatic contributions to molecular free energies in solution; site-specific analysis of mutational effects in proteins; allosteric transitions of the acetylcholine receptor; and deciphering the molecular code of hemoglobin allostery.

Readership

Biochemists, molecular biologists, biophysicists, and biomedical researchers.


Details

No. of pages:
473
Language:
English
Copyright:
© Academic Press 1998
Published:
Imprint:
Academic Press
eBook ISBN:
9780080582245
Hardcover ISBN:
9780120342518

Reviews

@from:Praise for the Volume @qu:"The contributions are by outstanding investigators who bring both a traditional perspective on this topic and expertise and knowledge in newer aspects and applications, such as protein-nucleic acid interactions...any investigator with interests in protein folding and stability, or protein-protein or protein-ligand interaction thermodynamics or in enzyme or receptor interaction thermodynamics should find this volume useful and informative... This volume is highly recommended for protein chemists, molecular or cell biologists who need a better understanding of these topics." @source:--DOODY'S PUBLISHING REVIEWS (4 star rating) @from:Praise for the Series @qu:"The authority, originality, and editing of the reviews are first class." @source:--NATURE @qu:"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists." @source:--JOURNAL OF THE AMERICAN CHEMICAL SOCIETY


About the Serial Editors

Frederic Richards Serial Editor

Affiliations and Expertise

Yale University, New Haven, Connecticut, U.S.A.

David Eisenberg Serial Editor

Affiliations and Expertise

University of California, Los Angeles, U.S.A.

Peter Kim Serial Editor

Affiliations and Expertise

Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research, Howard Hughes Medical Institute Research Laboratories, Cambridge, U.S.A.

About the Serial Volume Editors

Enrico Di Cera Serial Volume Editor

Affiliations and Expertise

Washington University School of Medicine, St. Louis, Missouri, U.S.A.