Linkage Thermodynamics of Macromolecular Interactions

Linkage Thermodynamics of Macromolecular Interactions

1st Edition - May 20, 1998

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  • Editor: Enrico Di Cera
  • eBook ISBN: 9780080582245

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Description

This volume commemorates the 50th anniversary of the appearance in Volume 4 in 1948 of Dr. Jeffries Wyman's famous paper in which he "laid down" the foundations of linkage thermodynamics. Experts in this area contribute articles on the state-of-the-art of this important field and on new developments of the original theory. Among the topics covered in this volume are electrostatic contributions to molecular free energies in solution; site-specific analysis of mutational effects in proteins; allosteric transitions of the acetylcholine receptor; and deciphering the molecular code of hemoglobin allostery.

Readership

Biochemists, molecular biologists, biophysicists, and biomedical researchers.

Table of Contents

  • M. Schaefer, H. van Vlijmen, and M. Karplus, Electrostatic Contributions to Molecular Free Energies in Solution.
    E. Di Cera, Site-Specific Analysis of Mutational Effects in Proteins.
    S.J. Edelstein and J.-P. Changeux, Allosteric Transitions of the Acetylcholine Receptor.
    G.K. Ackers, Deciphering the Molecular Code of Hemoglobin Allostery.
    E. Freire, Statistical Thermodynamic Linkage between Conformational and Binding Equilibria.
    M.T. Record, Jr., W. Zhang, and C.F. Anderson, Analysis of the Effects of Salts and Uncharged Solutes on Protein and Nucleic Acid Equilibria and Processes: A Practical Guide to Recognizing and Interpreting Polyelectrolyte Effects, Hofmeister Effects, and Osmotic Effects of Salts.
    S.N. Timasheff, Control of Protein Stability and Reactions by Weakly Interacting Cosolvents: The Simplicity of the Complicated.
    Author Index.
    Subject Index.

Product details

  • No. of pages: 473
  • Language: English
  • Copyright: © Academic Press 1998
  • Published: May 20, 1998
  • Imprint: Academic Press
  • eBook ISBN: 9780080582245

About the Serial Volume Editor

Enrico Di Cera

Affiliations and Expertise

Washington University School of Medicine, St. Louis, Missouri, U.S.A.

About the Serial Editors

Frederic Richards

Affiliations and Expertise

Yale University, New Haven, Connecticut, U.S.A.

David Eisenberg

Affiliations and Expertise

University of California, Los Angeles, U.S.A.

Peter Kim

Affiliations and Expertise

Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research, Howard Hughes Medical Institute Research Laboratories, Cambridge, U.S.A.

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