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Asthma and COPD - 1st Edition - ISBN: 9780120790289, 9780080488356

Asthma and COPD

1st Edition

Basic Mechanisms and Clinical Management

Authors: Peter Barnes Jeffrey Drazen Stephen Rennard Neil Thomson
Hardcover ISBN: 9780120790289
eBook ISBN: 9780080488356
Imprint: Academic Press
Published Date: 22nd April 2002
Page Count: 780
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Chronic obstructive pulmonary disease (COPD), which encompasses both chronic bronchitis and emphysema, is one of the most common respiratory conditions of adults in the developed world. Asthma and COPD: Basic Mechanisms and Clinical Management provides a unique, authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it is a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments.

Key Features

  • Highlights distinguishing features between asthma and COPD
    * Reviews benefits and limitations of current therapies
    * Summarises key information in two-colour artwork
    * Extensively referenced to primary literature


Cell biologists, immunologists, pharmacologists, and physicians working in pulmonary research in academia or the pharmaceutical industry.

Table of Contents






Part I: Definitions, Epidemiology, and Genetics of Asthma and COPD

1 Definitions

2 Epidemiology

3 Natural History

4 Genetics

Part II: Physiology and Pathology of Asthma and COPD

5 Pulmonary Physiology

6 Airway Pathology

7 Airway Remodeling

8 Animal Models

Part III: Inflammatory Cells and Extracellular Matrix

9 Mast Cells and Basophils

10 Macrophages

11 Eosinophils

12 Lymphocytes

13 Neutrophils

14 Fibroblasts

15 Epithelial Cells

16 Mucus and Mucin-Secreting Cells

17 Airway Smooth Muscle

18 Tracheobronchial Circulation

19 Pulmonary Vessels

20 Plasma Exudation

21 Cell Adhesion Molecules,

22 Extracellular Matrix

Part IV: Inflammatory Mediators and Pathways

23 Prostanoids

24 Leukotrienes

25 Kinins

26 Reactive Oxygen Species

27 Chemokines

28 Cytokines

29 Matrix Degrading Proteinases

30 Growth Factors

31 Other Mediators of Airway Disease

32 Nitric Oxide

33 Transcription Factors

34 Neural and Humoral Control

Part V: Pathogenic Mechanisms in Asthma and COPD

35 Pathophysiology of Asthma

36 Pathogenesis of COPD

Part VI: Triggers of Asthma and COPD

37 Allergens

38 Occupational Agents

39 Infections

40 Exercise as a Trigger

41 Atmospheric Pollutants

42 Drugs

Part VII: Clinical Assessment of Asthma and COPD

43 Diagnosis

44 Non-invasive Assessment of Airway Inflammation

45 Imaging

46 Assessment of Disability

Part VIII: Therapies for Asthma and COPD

47 Allergen Avoidance

48 Smoking Cessation

49 b2-adrenoceptor Agonists

50 Anticholinergic Bronchodilators

51 Theophylline

52 Corticosteroids

53 Mediator Antagonists

54 Antibiotics

55 Long-term Oxygen Therapy

56 Immunomodulators

57 Pulmonary Vasodilators

58 Ventilator Support

59 Pulmonary Rehabilitation

60 Surgery

61 Other Therapies

62 Future Therapies

63 Health Economics

Part IX: Clinical Management of Asthma and COPD

64 Management of Chronic Asthma in Adults

65 Acute Exacerbations of Asthma

66 Childhood Asthma

67 Treatment for Stable COPD

68 Acute Exacerbations of COPD

69 Education and Self-Management



No. of pages:
© Academic Press 2002
22nd April 2002
Academic Press
Hardcover ISBN:
eBook ISBN:

About the Authors

Peter Barnes

Peter Barnes is Professor of Thoracic Medicine at the National Heart and Lung Institute, Head of Respiratory Medicine at Imperial College and Honorary Consultant Physician at Royal Brompton Hospital, London. He qualified at Cambridge and Oxford Universities was appointed to his present post in 1987. He has published over 1000 peer-review papers on asthma, COPD and related topics and has edited over 40 books. He is also amongst the top 50 most highly cited researchers in the world and has been the most highly cited clinical scientist in the UK and the most highly cited respiratory researcher in the world over the last 20 years. He was elected a Fellow of the Royal Society in 2007, the first respiratory researcher for over 150 years. He is currently a member of the Scientific Committee of the WHO/NIH global guidelines on asthma (GINA) and COPD (GOLD). He also serves on the Editorial Board of over 30 journals and is currently an Associate Editor of Chest and respiratory Editor of PLoS Medicine. He has given several prestigious lectures, including the Amberson Lecture at the American Thoracic Society and the Sadoul Lecture at the European Respiratory Society.

Affiliations and Expertise

Head of Respiratory Medicine, Imperial College, London, UK, Airway Disease Section, National Heart and Lung Institute

Jeffrey Drazen

Jeffrey M. Drazen, MD, was born in St. Louis, Missouri. He graduated from Tufts University with a major in physics, and from Harvard Medical School. He served his medical internship and residency at Peter Bent Brigham Hospital in Boston and was a clinical fellow and research fellow at Harvard Medical School and Harvard School of Public Health. Thereafter, he joined the Pulmonary Divisions of the Harvard hospitals and served for many years as chief of the combined Pulmonary Divisions at Beth Israel and Brigham and Women’s Hospitals.

Currently, he is a Senior Physician at the Brigham and Women’s Hospital, and the Distinguished Parker B. Francis Professor of Medicine at Harvard Medical School, as well as Professor of Physiology, Harvard School of Public Health and adjunct Professor of Medicine at Boston University School of Medicine.

He has served on the NIH Respiratory and Applied Physiology Study Section, the NIH Pulmonary Disease Advisory Council, the NIH Lung Biology and Pathology Study Section, and the NHLBI Advisory Council.

Through his research, he defined the role of novel endogenous chemical agents in asthma. This led to four new licensed pharmaceuticals for asthma used in the treatment of millions of people worldwide. He has published nearly 500 papers and edited 6 books.

He has been a member of the editorial boards of many prestigious journals, including: the Journal of Applied Physiology, American Journal of Physiology, Pulmonary Pharmacology, Experimental Lung Research, Journal of Clinical Investigation, American Journal of Respiratory Cell and Molecular Biology, and the American Journal of Medicine. In addition, he has been associate editor of the Journal of Clinical Investigation and the American Review of Respiratory Disease.

In 2000, he assumed the post of editor-in-chief of the New England Journal of Medicine. During his tenure, the Journal has published major papers advancing the science of medicine.

Affiliations and Expertise

Brigham and Women's Hospital, Boston, MA, USA

Stephen Rennard

Affiliations and Expertise

University of Nebraska Medical Center, Omaha, USA

Neil Thomson

Neil Thomson is Professor of Respiratory Medicine at the University of Glasgow, Head of Respiratory Medicine within the Division of Immunology, Infection & Inflammation and Honorary Consultant at Gartnavel General Hospital, Glasgow. He graduated from the University of Glasgow and undertook postgraduate training in Glasgow, London and McMaster University, Canada. He is a former member of the Committee for Safety of Medicine and former Chair of the Scientific Committee of the British Lung Foundation. He has co-edited several textbooks on asthma and COPD and published over 150 peer-reviewed papers on asthma. His current research interests include corticosteroid insensitivity in smokers with asthma, biomarkers in asthma and COPD and assessment of novel treatments for asthma.

Affiliations and Expertise

Western Infirmary, Glasgow, Scotland

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