Learning and Memory

Learning and Memory

A Biological View

2nd Edition - January 28, 1986

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  • Author: Author Unknown
  • eBook ISBN: 9780323137683

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Description

Learning and Memory: A Biological View is a comprehensive textbook about the neurobiology of learning and memory. Topics covered range from anatomical correlates of neuronal plasticity to drugs that modulate learning and memory, along with biochemical correlates of learning and memory. The effect of aging on memory and electrophysiological analogs of memory are also discussed. Comprised of 12 chapters, this book begins with a review of historical traditions that influenced research on the biological basis of learning and memory. Experimental results indicating that the engram for a simple classically conditioned skeletal response may be in the cerebellum are also summarized. The next chapter stresses the importance of anatomical mechanisms that could mediate learning, plasticity, and memory storage in young and adult animals. Subsequent chapters focus on the influence of peripheral hormones, including opioid peptides, on learning and memory; the contribution of individual neurotransmitter systems to learning; the psychopathology of aging; and long-term potentiation. Learning in complex vertebrate systems and direct stimulation of various brain nuclei are also considered. The final chapter presents a neurobehavioral analysis of the structure of memory formation that utilizes lesions and explores human memory pathology. This monograph is intended for advanced undergraduate students, graduate students, and research workers in the field of memory.

Table of Contents


  • Contributors

    Preface

    I Historical Introduction

    1 The Search for the Engram

    Introduction

    A Brief History

    Modern Approaches to the Problem of Localization

    Some Definitions and Issues

    Early Experience, Brain Development, and Learning

    Memory Consolidation

    The Chemistry of Memory

    Cognitive Science and Neuropsychology

    The Model Biological System Approach

    Case History of a Model Biological System

    References

    II Anatomical Approaches

    2 Developmental Approaches to the Memory Process

    Introduction

    Some Historical Aspects of Memory Ontogeny Research

    Experience-Expectant and Experience-Dependent Neural Plasticity

    Quantitative Methods in Developmental Neurobiology

    Neurobiological Correlates of Memory Ontogeny

    Implications for the Neurobiological Study of Memory

    References

    3 Anatomical Correlates of Neuronal Plasticity

    Introduction

    Focus on the Synapse

    Anatomical Plasticity During Development

    Anatomical Correlates of Learning in Maturity

    Anatomical Rearrangements Following Injury

    Functional Significance of Anatomical Plasticity

    Summary and Conclusions

    References

    III Pharmacology and Biochemistry

    4 Memory: Drugs and Hormones

    Introduction

    Time Dependency Revisited

    U-Shaped Curves

    Modulation of Learning and Memory

    Central Versus Peripheral Actions of Drugs

    Which Neurotransmitter Systems are Important for Learning and Memory?

    Protein Synthesis Inhibitors

    Hormones and Learning and Memory

    Learning Modulatory Hormones

    Drugs to Understand or to Alter Learning and Memory?

    Conclusions

    References

    5 Biochemical Correlates of Learning and Memory

    Introduction

    Which Neurochemical Systems?

    Where in the Brain?

    When?

    Behavioral Specificity

    Specific Molecules

    Conclusions

    References

    6 Applied Aspects of Memory Research: Aging

    Prologue

    Introduction

    Behavioral Studies: Memory Deficits with Normal Aging

    Neurobiological Studies

    Summary and Conclusions

    References

    IV Model Systems

    7 Memory: Electrophysiological Analogs

    Introduction

    Electrophysiological Approaches

    The Hippocampus

    Hippocampal Electrophysiology

    Hippocampal Response Plasticity

    LTP as a Substrate for Memory

    LTP as a Candidate Memory Mechanism

    The Hippocampal Memory Indexing Theory

    References

    8 Memory: Invertebrate Model Systems

    Introduction

    The Need for Unifying Principles

    Aplysia

    Hermissenda

    Limax

    Pleurobranchaea

    Correlation Versus Causality in Cellular Studies of Learning

    General Principles of Learning in Invertebrate Model Systems

    Conclusions

    References

    9 Memory: Vertebrate Model Systems

    Introduction

    Characteristics of an Ideal Vertebrate Behavioral Model System

    Analysis of the Neural Circuitry Mediating the Acquisition of Nonspecific Model Response Systems

    Analysis of the Neural Circuitry Mediating the Acquisition of Specific Model Response Systems

    Concluding Remarks

    Summary

    References

    10 Studies of Memory Processes Using Electrical Brain Stimulation

    Introduction

    Memory Impairment Produced by Electrical Brain Stimulation

    Memory Facilitation by Electrical Brain Stimulation

    Electrical Brain Stimulation in Humans

    Summary

    References

    V Lesions

    11 Interventional Approaches to Memory: Lesions

    Introduction

    Structures, Functions, and Lesions

    Misuse of Lesion Analyses

    Dissociations

    Systematic Lesion Analyses

    Quantitative Manipulations of Structures and Functions

    Sensitivity and Selectivity

    Units of Analysis

    Temporal Variables

    Validity

    Memory

    Conclusions

    References

    12 Neurobiological Views of Memory

    Introduction

    Lashley

    Thompson

    Squire and Cohen

    Mishkin

    O'Keefe and Nadel

    Olton

    Kesner

    Integration

    Summary

    References

    Index

Product details

  • Language: English
  • Copyright: © Academic Press 1986
  • Published: January 28, 1986
  • Imprint: Academic Press
  • eBook ISBN: 9780323137683

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