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Lanzkowsky's Manual of Pediatric Hematology and Oncology - 7th Edition - ISBN: 9780128216712

Lanzkowsky's Manual of Pediatric Hematology and Oncology

7th Edition

Editors: Jonathan Fish Jeffrey Lipton Philip Lanzkowsky
Hardcover ISBN: 9780128216712
Imprint: Academic Press
Published Date: 1st June 2021
Page Count: 826
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Lanzkowsky’s Manual of Pediatric Hematology and Oncology, Seventh Edition remains the go-to clinical manual for the treatment and management of childhood cancers and blood disorders. It is a comprehensive book on patient management, replete with algorithms and flow diagrams, and includes a new section on vascular anomalies. Reflecting the considerable advances in the treatment and management of hematologic and oncologic diseases in children, the seventh edition of this successful clinical manual is entirely updated to incorporate all current treatment protocols, new drugs, and management approaches. Its concise and easy-to-read format, again, enables readers to make accurate diagnoses and treatment decisions without having to reference larger medical textbooks.

Key Features

  • Designed to be easily readable and highly practical with over 400 illustrative tables, along with color diagrams and figures
  • New chapter on Pediatric Vascular Anomalies
  • New content on ‘blood avoidance’ programs to honor religious preferences
  • Discussions of new drugs and immunological therapies for cancers, along with discussions of increasing use of cytokine stimulants for hematologic disorders
  • Includes practical genetic evaluations providing a deeper understanding and advances in management of bone marrow failure diseases


Fellows and residents in pediatric hematology/oncology; pediatric hematologists, pediatric oncologists, pediatricians; clinical researchers in pediatric hematology/oncology

Table of Contents

  1. Molecular and genomic methodologies for clinicians
    2. Hematologic manifestations of systemic lllness
    3. Classification and diagnosis of anemia in children and neonates
    4. Nutritional anemias
    5. Lymphadenopathy and diseases of the spleen
    6. Bone marrow failure
    7. General considerations of hemolytic diseases, red cell membrane, and enzyme defects
    8. Extracorpuscular hemolytic anemia
    9. Hemoglobinopathies
    10. Primary and secondary erythrocytosis
    11. Disorders of white blood cells
    12. Disorders of platelets
    13. Disorders of coagulation
    14. Vascular anomalies
    15. Histiocytic disorders
    16. Lymphoproliferative disorders
    17. Myelodysplastic syndromes and myeloproliferative disorders
    18. Acute lymphoblastic leukemia
    19. Acute myeloid leukemia
    20. Hodgkin lymphoma
    21. Non-Hodgkin lymphoma
    22. Central nervous system tumors
    23. Neuroblastoma
    24. Renal tumors
    25. Rhabdomyosarcoma and other soft-tissue sarcomas
    26. Malignant bone tumors
    27. Retinoblastoma
    28. Extracranial germ cell tumors
    29. Hepatic tumors
    30. Hematopoietic stem cell transplant and cellular therapy
    31. Management of oncologic emergencies
    32. Supportive care of patients with cancer
    33. Evaluation, investigations, and management of late effects of childhood cancer
    34. Psychosocial factors impacting children with cancer and their families
    35. Pediatric blood banking principles and transfusion medicine practices


No. of pages:
© Academic Press 2021
1st June 2021
Academic Press
Hardcover ISBN:

About the Editors

Jonathan Fish

Jonathan D. Fish, MD is Assistant Professor of Pediatrics at the Hofstra Northwell School of Medicine. He is Director of the Survivors Facing Forward Program, a long-term follow-up program for survivors of childhood cancer, in the division of Pediatric Hematology/Oncology and Stem Cell Transplantation at the Steven and Alexandra Cohen Children’s Medical Center of New York. He holds a B.A., with distinction, from the University of Western Ontario and received his M.D. degree, magna cum laude, from the Upstate Medical Center of the State University of New York. He did his Pediatric training at the the Schneider Children’s Hospital, New Hyde Park, NY ( Presently known as the Steven and Alexandra Children’s Medical Center of New York) and completed his Pediatric Hematology-Oncology fellowship training at the Children’s Hospital of Philadelphia. Dr. Fish received the American Society of Pediatric Hematology-Oncology Young Investigator Award in 2008. His clinical and research interest is on the late effects of childhood cancer treatment and survivorship care.

Affiliations and Expertise

Attending Physician, Department of Pediatric Hematology/Oncology, Steven and Alexandra Cohen Children's Medical Center, New Hyde Park, NY; Assistant Professor of Pediatrics, Hofstra Northwell School of Medicine, Hempstead, NY, USA

Jeffrey Lipton

Jeffrey M. Lipton, MD, PhD is the Chief of Hematology/Oncology and Stem Cell Transplantation at the Steven and Alexandra Cohen Children’s Medical Center of New York and Center Head, Patient Oriented Research, The Feinstein Institute for Medical Research. He is Professor, Elmezzi Graduate School of Molecular Medicine, The Feinstein Institute for Medical Research and Professor of Pediatrics and Molecular Medicine at the Hofstra North Shore – LIJ School of Medicine. He holds a B.A. from Queens College, City University of New York, a Ph.D in Chemistry from Syracuse University and an M.D. degree, magna cum laude, from Saint Louis University Medical School. He did his Pediatric residency training at the Children’s Hospital, Boston, MA and his Pediatric Hematology/Oncology fellowship training at the Children’s Hospital and the Sidney Farber Cancer Institute (now DFCI) in Boston. Dr. Lipton is a Past-President of the American Society of Pediatric Hematology/Oncology (ASPHO). His main interest is bone marrow failure.

Affiliations and Expertise

Head, Patient Oriented Research, The Feinstein Institute for Medical Research; Chief, Hematology/Oncology and Stem Cell Transplantation, Steven and Alexandra Cohen Children’s Medical Center of New York; Professor of Pediatrics and Molecular Medicine, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA

Philip Lanzkowsky

Dr. Philip Lanzkowsky was born in Cape Town on March 17, 1932 and graduated high school from the South African College and obtained his MB ChB degree from the University of Cape Town School of Medicine in 1954 and his Doctorate degree in 1959 for his thesis on Iron Deficiency Anemia In Children. He completed a pediatric residency at the Red Cross War Memorial Children’s Hospital in Cape Town in 1960. After working in Pediatrics at the University of Edinburgh and at St Mary’s Hospital of the University of London, Dr. Lanzkowsky did a pediatric Hematology-Oncology fellowship at Duke University School of Medicine and at the University of Utah. In 1963 he was appointed Consultant Pediatrician and Pediatric Hematologist to the Red Cross War Memorial Children’s Hospital at the University of Cape Town and introduced Pediatric Hematology and Oncology as a distinct discipline. In 1965 he was appointed Director of Pediatric Hematology and Associate Professor of Pediatrics at the New York Hospital-Cornell University School of Medicine. In 1970 he was appointed Professor of Pediatrics and Chairman of Pediatrics at Long Island Jewish Medical Center and established a division of Pediatric Hematology-Oncology which he directed until 2000. He was the founder of the Schneider Children’s Hospital, which he developed, planned, and was the hospital’s Executive Director and Chief of Staff from its inception in 1983 until 2010. Dr. Lanzkowsky has received numerous honors and awards and has lectured extensively at various institutions and medical schools in the United States and around the world. In addition to having been the author of five editions of the Manual of Pediatric Hematology and Oncology used by clinicians worldwide, he is the author of How It All Began: The History of a Children’s Hospital and over 280 scientific papers, abstracts, monographs, and book chapters. Dr. Lanzkowsky’s medical writings have been prodigious. His seminal contributions to the medical literature have included the first description of the relationship of pica to iron-deficiency anemia (Arch. Dis Child., 1959), Effects of timing of clamping of umbilical cord on infant’s hemoglobin level (Br. Med. J., 1960), Normal oral D-xylose test values in children (New Engl. J. Med., 1963), Normal coagulation factors in women in labor and in the newborn (Thromboses at Diath. Hemorr., 1966), Erythrocyte abnormalities induced by malnutrition (Br. J. Haemat., 1967), Radiologic features in iron deficiency anemia (Am. J. Dis. Child., 1968), Isolated defect of folic acid absorption associated with mental retardation (Blood, 1969; Am. J. Med, 1970), Disaccharidase levels in iron deficiency (J. Pediat., 1981) and Hexokinase “New Hyde Park” in a Chinese kindred (Am. J. Hematol., 1981).

Affiliations and Expertise

Chief Emeritus, Pediatric Hematology-Oncology, Chairman Emeritus, Department of Pediatrics, Executive Director and Chief-of-Staff (Retired), Steven and Alexandra Cohen Children's Medical Center, New Hyde Park, NY, USA, Vice President, Children's Health Network (Retired), North Shore-Long Island Jewish Health System, Consultant, Steven and Alexandra Cohen Children's Medical Center of New York, Professor of Pediatrics, Hofstra Northwell School of Medicine, Hempstead, NY, USA


Praise for the 7th Edition:

“Even in this digital age, Lanzkowsky’s Manual of Pediatric Hematology and Oncology remains the essential manual for pediatric hematology/oncology trainees, junior faculty and even senior investigators. The manual serves as a concise yet comprehensive guide that can steer physicians at any stage of their careers to best practices in areas both common and rare. The Manual is an authoritative and well-illustrated compendium that should be on the must have list of every pediatric hematologist and oncologist.” — John M. Maris, MD, D'Angio Professor of Pediatrics, Children's Hospital of Philadelphia, Philadephia, Pennsylvania, USA

Lanzkowsky’s Manual of Pediatric Hematology and Oncology, now in its 7th edition, has long had a fundamental place in the training of paediatric haematologists and oncologists, and provided subsequent support during their career due to its authoritative, concise and clear presentation of the speciality. It now constitutes a canonical work in haematology and as such acts as a reference tool to support the work of paediatric haematology departments and the personal development of senior clinicians and scientists. I very much welcome this new edition.” — Professor Josu de la Fuente PhD FRCP FRCPI FRCPCH FRCPath, Consultant Haematologist and Director Paediatric Blood and Marrow Transplant Programme, St Mary’s Hospital and Imperial College London, London, UK

“I have been using Lanzkowsky’s Manual of Pediatric Hematology Oncology since it was first published in 1980. The Manual is a very valuable ready reference, written in a didactic way, filled with excellent algorithms and up-to-date treatment regimens, which are extremely useful to the clinician. I highly recommend it to all students and practitioners of pediatric hematology and oncology as an essential reference book.” — Cyril Karabus MB, ChB, MMed Paed (UCT), DCH, FRCP (London), FRCP (Edin), Emeritus Associate Professor of Pediatrics, University of Cape Town, Cape Town, South Africa

Lanzkowsky’s Manual of Pediatric Hematology and Oncology was the first book I bought when I started my fellowship at the NIH in 1993 and I am thrilled to see the seventh edition. I recently read the sixth edition, cover to cover, in preparation for becoming the Director of a large Pediatric Hematology Oncology Division. Amazingly, Dr. Lanzkowsky and his colleagues managed to incorporate in a reasonable-sized book, both the practical “recipes” for diagnosis and management of common as well as serious and rare oncologic and hematologic disorders. The new scientific revolution has been translated into precision medicine and brings us closer to curing every child with cancer and to the precise diagnosis and management of patients with serious hematologic disorders. These new advances and therapies are covered in the new edition in a clear and authoritative way. I recommend this book without hesitation to students, residents, fellows, attending physicians, nurses, diagnostic hematological laboratories, and yes, to Directors of Hematology Oncology services like myself.” — Shai Izraeli, Prof of Hematological Malignancies at Tel Aviv University, Head of the Rina Zaizov Division of Pediatric Hematology Oncology at Schneider Children’s Medical Center of Israel, Treasurer and Head of Research the European Hematology Association.

“The Lanzkowsky Manual was the first manual I consulted when I was a resident interested in pediatric hematology and oncology; over the years the Manual has remained close at hand as it has grown, keeping pace with the field. I continue to consult it often and recommend it highly to international colleagues for its practical and up-to-date guidance.” — Carlos Rodriguez-Galindo, MD, Executive Vice-President, Director, St. Jude Global, Chair, Department of Global Pediatric Medicine, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

“The 7th edition Lanzkowsky’s Manual of Pediatric Hematology and Oncology provides an excellent up-to-date reference for teaching and practicing pediatric hematology and oncology (PHO).  Written by leaders in the field, it can be used as a comprehensive reference while at the same time, it is a concise, well-organized manual that you can access for a fast look while on-call, addressing common and rare PHO conditions with an algorithmic approach.  I recommend this book without hesitation.” — Theodosia A. Kalfa, MD, PhD, Professor of Pediatrics, Co-Director of the Erythrocyte Diagnostic Laboratory, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA

Ratings and Reviews