Lahita's Systemic Lupus Erythematosus

Lahita's Systemic Lupus Erythematosus

6th Edition - July 23, 2021

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  • Editor: Robert Lahita
  • eBook ISBN: 9780323914888
  • Hardcover ISBN: 9780128205839

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Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness.To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries.

Key Features

  • Completely updated, revised, and expanded with the most comprehensive and accessible reference on SLE for clinicians and scientists
  • Full-color presentation throughout the book
  • Provides the latest information available on diagnosis and treatment
  • Incorporates an international panel of authors who are experts in their fields, with an emphasis on young, cutting-edge scientists and physicians


Primary audience is basic scientists and clinicians who are interested in SLE including rheumatologists, dermatologists, nephrologists, immunologists and allergists

Table of Contents

  • Part I: Basis of the Disease
    Section A: Genetics and epigenetics
    1. Major histocompatibility complex and SLE
    2. Lupus Susceptibility genes
    3. Epigenetics in systemic lupus erythematosus and the integration of molecular pathways

    Section B: Immunopathogenesis
    4. Autoantigens, antigenic mimicry, and immune complexes
    5. B-cell Biology, tolerance and autoantibodies
    6. T-Cell Biology, tolerance and regulation
    7. Polymorphonuclear cells
    8. Metabolic and mitochondrial dysfunction in SLE
    9. Immunopathogenesis: the role of mucosal and skin microbiota in SLE

    Section C: Disease effectors and modifiers
    10. Complement and SLE
    11. Interferons and cytokines in SLE pathogenesis and therapy
    12. Innate immunity in SLE pathogenesis
    13. Sex bias in SLE

    Section D: Tissue injury—the Biology
    14. Mechanisms of tissue injury in lupus nephritis
    15. The skin
    16. The brain in SLE: mechanisms and detection of injury and therapeutic strategies
    17. The role of infections in SLE pathogenesis
    18. Tissue injurydthe biology: SLE-associated vascular disease and antiphospholipid syndrome

    Part II: Clinical presentation of disease
    Section A: Clinical presentation

    19. Epidemiology of SLE and related diseases: incidence, prevalence, and mortality
    20. The clinical presentation of systemic lupus erythematosus and laboratory diagnosis
    21. Passively acquired lupus in the fetus and neonate
    22. Systemic lupus erythematosus in children
    23. Environmental and drug-induced lupus
    24. Reproductive health
    25. Monitoring disease activity
    26. Overlap syndromes

    Section B: Specific organ involvement and clinical presentation
    27. Nervous system
    28. Skin
    29. Kidney disease
    30. Cardiovascular disease in lupus
    31. Pulmonary manifestations of systemic lupus erythematosus
    32. GI hepatic and nonhepatic diseases
    33. Musculoskeletal system: articular disease, myositis, and bone metabolism
    34. Clinical presentation of antiphospholipid syndrome
    35. Hematology: cytopenias
    36. Malignancy risk and screening

    Section C: Treatment of systemic llupus erythematosus
    37. Antimalarial drugs (and lupus)
    38. Glucocorticoids
    39. Immunosuppressive therapy in SLE
    40. Pipeline therapies and future drug development
    41. Challenges of systemic lupus clinical trials

Product details

  • No. of pages: 730
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: July 23, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780323914888
  • Hardcover ISBN: 9780128205839

About the Editor

Robert Lahita

Dr. Robert Lahita is Clinical Professor of Medicine at Rutgers University, and the Director of the Institute for Autoimmune and Rheumatic Diseases. He is a fellow of the ACP and the Royal College, and a master of the ACR. Dr. Lahita is the author of more than 16 books and 150 scientific publications in the field of autoimmunity. He is the editor of the standard textbook Systemic Lupus Erythematosus and the Senior Editor of the Textbook of Autoimmunity, and the author of Lupus: Q and A for patients and Autoimmunity in Women.

Affiliations and Expertise

Professor of Medicine, Adjunct Professor of Biochemistry and Molecular Biology UMDNJ, New Jersey Medical School Vice President and Chairman of Medicine Newark Beth Israel Medical Center Newark, NJ, USA

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