Laboratory Safety Theory and Practice
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Laboratory Safety: Theory and Practice focuses on theoretical aspects of the hazards the students, technicians, and scientists encounter in the laboratory. It presents methods of risk assessment that can be applied to technologies as they are translated from the scientist’s mind to the laboratory bench. It is organized into three sections designated as General Laboratory Safety, Biological Laboratory Safety, and Medical and Psychological Factors. The first section, encompassing three chapters, discusses hazards found in almost all laboratories; pertinent safety theories and practices; ubiquitous compounds that are either toxic or carcinogenic and guidelines for their use; and radiation hazards. Chapters 4 to 7 focus on the safety in the biological laboratory. Discussions on relatively complex group of viruses, approach to recombinant DNA research, and awareness on the possible hazards associated with the field are included in this book. Chapters 6 and 7 present design and function of biohazard laboratories and the hazards relating to laboratory animals. The final section discusses medical surveillance of persons at risk and the psychological factors involved in accident control. It presents a comprehensive list of chemical agents, their sources, subsequent physical effects, and the accepted mode of medical surveillance. Various genetic screening tests and their potential use for the evaluation of presumptive and actual mutagens are also covered. This book is ideal for safety and design engineers, students, technicians, and scientists.
Table of Contents
List of Contributors
Preface
Part One: General Laboratory Safety
Chapter One Physical, Chemical, and Fire Safety
I. Introduction
II. Human Factors
III. Energy Factors and Control Strategies
IV. Haddon's Measures for the Prevention or Limitation of Laboratory Incidents and Injuries
V. Mechanical Hazards and Controls
VI. Thermal Hazards and Control Measures
VII. Chemical Hazards and Control Measures
VIII. Electrical Hazards and Control Measures
IX. Fire Hazards and Control Measures
X. Safety Management
References
Chapter Two Classes of Toxic Compounds: Procedures and Principles for Evaluating Toxicity
I. Introduction
II. Classification of Toxicity
III. Carcinogenicity
References
Chapter Three Radiation Hazards in the Laboratory
I. Introduction
II. Units of Radiation Measurement
III. Radiation Effects on Biological Systems
IV. Principles of Exposure Control
V. Regulations
VI. Instrumentation
VII. Personnel Monitoring: Purpose and Need
VIII. General Laboratory Procedures for Radidiisotope Work
IX. Specific Procedures for Users of Large Quantities of 3H, 32P, and 125I
Bibliography
Part Two: Biological Laboratory Safety
Chapter Four Viruses and Cancer
I. Introduction
II. DNA Oncogenic Viruses
III. RNA Tumor Viruses
IV. Discussion
References
Chapter Five Recombinant DNA Research
I. Introduction
II. The Importance of Molecular Cloning
III. In Vitro Cloning Procedures
IV. In Vivo Genetic Manipulation
V. Possible Hazards Associated with Recombinant DNA Research
References
Chapter Six Identification, Analysis, and Control of Biohazards in Viral Cancer Research
I. Introduction
II. Determinants of Laboratory Hazard
III. Criteria for Tumor Virus Classification
IV. Containment Systems and Control Practices
References
Chapter Seven Biohazards Associated with Laboratory Animals
I. Introduction
II. Hazards to Personnel
III. Experimental Hazard
IV. Hazard to Breeding Stock
V. Hazard to Domestic Animals
VI. Important Laboratory Zoonoses
VII. Factors Affecting Laboratory Zoonoses
VIII. Control of Animal Room Biohazards
IX. Estimation of Risk
X. Final Comment
References
Part Three: Medical and Psychological Factors
Chapter Eight Selected Medical Problems Often Associated with Laboratory Personnel
I. Introduction
II. Acute and Chronic Chemical Intoxications
III. Hypersensitivity Pneumonitis: A Model of Sensitization to Organic Material
IV. Carcinogens
V. Infections and Infestations
VI. The Pregnant Laboratory Worker
VII. Accidents and Injuries by Physical Agents
References
Chapter Nine Medical Aspects of Occupational Health in a Laboratory Setting
I. Introduction
II. Components of Occupational Health Programs
III. Personnel
IV. Risk Assessment
V. Occupational Health Program
VI. Occupational Health Program Example
VII. Conclusion
VIII. Appendix
References
Chapter Ten Genetic Monitoring
I. Introduction
II. Economic Impact
III. Test Systems for Determination of Mutagenicity
IV. Test Systems for Determination of Carcinogenicity
References
Chapter Eleven Behavioral Factors in Laboratory Safety: Personnel Characteristics and the Modification of Unsafe Acts
I. Behavioral Factors That Result in Accidents
II. Task Factors Related to Accidents
III. The Modification of Unsafe Behavior Patterns
References
Appendix: Classification of Agents
Index
Product details
- No. of pages: 372
- Language: English
- Copyright: © Academic Press 1980
- Published: December 28, 1980
- Imprint: Academic Press
- eBook ISBN: 9780323153652
About the Editor
Anthony Fuscaldo
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