Laboratory Safety Theory and Practice

Laboratory Safety Theory and Practice

1st Edition - December 28, 1980

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  • Editor: Anthony Fuscaldo
  • eBook ISBN: 9780323153652

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Laboratory Safety: Theory and Practice focuses on theoretical aspects of the hazards the students, technicians, and scientists encounter in the laboratory. It presents methods of risk assessment that can be applied to technologies as they are translated from the scientist’s mind to the laboratory bench. It is organized into three sections designated as General Laboratory Safety, Biological Laboratory Safety, and Medical and Psychological Factors. The first section, encompassing three chapters, discusses hazards found in almost all laboratories; pertinent safety theories and practices; ubiquitous compounds that are either toxic or carcinogenic and guidelines for their use; and radiation hazards. Chapters 4 to 7 focus on the safety in the biological laboratory. Discussions on relatively complex group of viruses, approach to recombinant DNA research, and awareness on the possible hazards associated with the field are included in this book. Chapters 6 and 7 present design and function of biohazard laboratories and the hazards relating to laboratory animals. The final section discusses medical surveillance of persons at risk and the psychological factors involved in accident control. It presents a comprehensive list of chemical agents, their sources, subsequent physical effects, and the accepted mode of medical surveillance. Various genetic screening tests and their potential use for the evaluation of presumptive and actual mutagens are also covered. This book is ideal for safety and design engineers, students, technicians, and scientists.

Table of Contents

  • List of Contributors


    Part One: General Laboratory Safety

    Chapter One Physical, Chemical, and Fire Safety

    I. Introduction

    II. Human Factors

    III. Energy Factors and Control Strategies

    IV. Haddon's Measures for the Prevention or Limitation of Laboratory Incidents and Injuries

    V. Mechanical Hazards and Controls

    VI. Thermal Hazards and Control Measures

    VII. Chemical Hazards and Control Measures

    VIII. Electrical Hazards and Control Measures

    IX. Fire Hazards and Control Measures

    X. Safety Management


    Chapter Two Classes of Toxic Compounds: Procedures and Principles for Evaluating Toxicity

    I. Introduction

    II. Classification of Toxicity

    III. Carcinogenicity


    Chapter Three Radiation Hazards in the Laboratory

    I. Introduction

    II. Units of Radiation Measurement

    III. Radiation Effects on Biological Systems

    IV. Principles of Exposure Control

    V. Regulations

    VI. Instrumentation

    VII. Personnel Monitoring: Purpose and Need

    VIII. General Laboratory Procedures for Radidiisotope Work

    IX. Specific Procedures for Users of Large Quantities of 3H, 32P, and 125I


    Part Two: Biological Laboratory Safety

    Chapter Four Viruses and Cancer

    I. Introduction

    II. DNA Oncogenic Viruses

    III. RNA Tumor Viruses

    IV. Discussion


    Chapter Five Recombinant DNA Research

    I. Introduction

    II. The Importance of Molecular Cloning

    III. In Vitro Cloning Procedures

    IV. In Vivo Genetic Manipulation

    V. Possible Hazards Associated with Recombinant DNA Research


    Chapter Six Identification, Analysis, and Control of Biohazards in Viral Cancer Research

    I. Introduction

    II. Determinants of Laboratory Hazard

    III. Criteria for Tumor Virus Classification

    IV. Containment Systems and Control Practices


    Chapter Seven Biohazards Associated with Laboratory Animals

    I. Introduction

    II. Hazards to Personnel

    III. Experimental Hazard

    IV. Hazard to Breeding Stock

    V. Hazard to Domestic Animals

    VI. Important Laboratory Zoonoses

    VII. Factors Affecting Laboratory Zoonoses

    VIII. Control of Animal Room Biohazards

    IX. Estimation of Risk

    X. Final Comment


    Part Three: Medical and Psychological Factors

    Chapter Eight Selected Medical Problems Often Associated with Laboratory Personnel

    I. Introduction

    II. Acute and Chronic Chemical Intoxications

    III. Hypersensitivity Pneumonitis: A Model of Sensitization to Organic Material

    IV. Carcinogens

    V. Infections and Infestations

    VI. The Pregnant Laboratory Worker

    VII. Accidents and Injuries by Physical Agents


    Chapter Nine Medical Aspects of Occupational Health in a Laboratory Setting

    I. Introduction

    II. Components of Occupational Health Programs

    III. Personnel

    IV. Risk Assessment

    V. Occupational Health Program

    VI. Occupational Health Program Example

    VII. Conclusion

    VIII. Appendix


    Chapter Ten Genetic Monitoring

    I. Introduction

    II. Economic Impact

    III. Test Systems for Determination of Mutagenicity

    IV. Test Systems for Determination of Carcinogenicity


    Chapter Eleven Behavioral Factors in Laboratory Safety: Personnel Characteristics and the Modification of Unsafe Acts

    I. Behavioral Factors That Result in Accidents

    II. Task Factors Related to Accidents

    III. The Modification of Unsafe Behavior Patterns


    Appendix: Classification of Agents


Product details

  • No. of pages: 372
  • Language: English
  • Copyright: © Academic Press 1980
  • Published: December 28, 1980
  • Imprint: Academic Press
  • eBook ISBN: 9780323153652

About the Editor

Anthony Fuscaldo

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