Laboratory Exercises in Molecular Pathology - 1st Edition - ISBN: 9780128006085, 9780128006283

Laboratory Exercises in Molecular Pathology

1st Edition

Editors: Jonathon Homeister William Coleman Gregory Tsongalis
eBook ISBN: 9780128006283
Hardcover ISBN: 9780128006085
Imprint: Academic Press
Published Date: 3rd March 2019
Page Count: 400
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Description

Laboratory Exercises in Molecular Pathology is organized by major organ systems and disease type, presenting exercises that distill essential disease-specific information (related to frequency, risk factors, disease manifestations) and a description of disease pathogenesis (molecular and cellular) that is based upon accepted principles from today's literature. Each exercise is illustrated with (1) gross specimens, (2) microscopic histopathology, (3) immunohistochemistry and/or in situ hybridization (when applicable), (4) laboratory techniques to probe the molecular nature of the pathological lesions, and (5) molecular diagnostics (when applicable).

In addition, each exercise contains one or more cases studies to provide students with exposure to the clinical workup of a patient that are based upon physical examination findings, traditional pathological analysis, and state-of-the-art molecular assessment.

The laboratory techniques included emphasize the dissection of molecular and cellular pathogenesis of the disease in question. Hence, students will see examples of laboratory results that illustrate how pathways were elucidated. Further, the sections on molecular diagnostics illustrate how molecular testing exploits what is known about molecular pathogenesis in a specific disease setting.

Key Features

  • Presents foundational information with examples of gross and microscopic pathology and molecular approaches and testing
  • Offers an ancillary website with videos corresponding to the evaluation of gross specimens, the assessment of microscopic images, and a demonstration of laboratory techniques
  • Features exercises which contain one or more cases studies to provide students with exposure to the clinical workup of a patient
  • Provides case studies which include self-assessment modules and decision trees that allow students to make mistakes and then receive explanations

Readership

Biomedical graduate students studying disease and translational aspects of basic science; post-doctoral researchers and medical residents/fellows in pathology and laboratory medicine

Table of Contents

Section 1. Disorders of the Cardiovascular System
Section 2. Disorders of Blood and Bone Marrow
Section 3. Disorders of the Respiratory System
Section 4. Diseases of Infection
Section 5. Diseases of the Gastrointestinal System
Section 6. Disorders of the Liver and Exocrine Pancreas
Section 7. Disorders of the Kidney and Urinary System
Section 8. Disorders of the Female Reproductive System
Section 9. Disorders of the Male Reproductive System
Section 10. Disorders of the Endocrine System
Section 11. Disorders of the Skin, Bones, and Connective Tissue
Section 12. Disorders of the Central and Peripheral Nervous Systems

Details

No. of pages:
400
Language:
English
Copyright:
© Academic Press 2018
Published:
Imprint:
Academic Press
eBook ISBN:
9780128006283
Hardcover ISBN:
9780128006085

About the Editor

Jonathon Homeister

Jonathon W. Homeister earned Bachelor of Arts degrees in Biology and Chemistry in 1985 from Hope College, where he began his research endeavors mentored by Christoper C. Barney, Ph.D. He then earned the Doctor of Philosophy in Pharmacology, mentored by Benedict R. Lucchesi, M.D., Ph.D., and the Doctor of Medicine from the University of Michigan in 1993. He received residency training in anatomic pathology at the University of Michigan Hospitals and is a Diplomat of the American Board of Pathology. After residency, he received additional research training as an Associate of the Howard Hughes Medical Institute, mentored by John B. Lowe, M.D. He is currently an Associate Professor in the Department of Pathology and Laboratory Medicine, and member of the McAllister Heart Institute at the University of North Carolina at Chapel Hill, where he is also Director of the Molecular and Cellular Pathology Graduate Program. His clinical interests include cardiovascular, autopsy, and forensic pathology, and his research interests focus on the glycobiology inherent to leukocyte trafficking, with particular respect to the pathogenesis of cardiovascular diseases including atherosclerosis and thrombosis.

Affiliations and Expertise

University of North Carolina, Chapel Hill, USA

William Coleman

William B. Coleman, PhD is Professor of Pathology and Laboratory Medicine at the University of North Carolina School of Medicine (Chapel Hill, NC), and Director of the UNC Program in Translational Medicine. In addition, he is affiliated with the Curriculum in Toxicology, the Cancer Biology Training Program, and is a member of the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is actively involved in teaching biomedical graduate students and is a four-time recipient of the Joe W. Grisham Award for Excellence in Graduate Student Teaching from the Molecular and Cellular Pathology graduate students at UNC-Chapel Hill. Dr. Coleman is active in the leadership of the American Society for Investigative Pathology, and is a member of the American Association for Cancer Research. He serves as an associate editor for The American Journal of Pathology, BMC Cancer, and PLoS One, and serves on the editorial boards of Clinica Chimica Acta, Experimental and Molecular Pathology, Archives of Pathology and Laboratory Medicine, Laboratory Investigation, and Current Pathobiology Reports, and has served as an ad hoc reviewer for 95 other journals. Dr. Coleman’s major research interests are in the molecular pathogenesis of human cancers, with a specific interest in breast cancer epigenetics, liver carcinogenesis, and lung cancer biology. His research has been funded by the NIH/NCI, The Susan G. Komen Breast Cancer Foundation, Friends for an Earlier Breast Cancer Test, and the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is the author of over 125 original research articles, reviews, and book chapters. In addition, Dr. Coleman has co-edited or co-authored eight books on topics related to molecular pathology, molecular diagnostics, and the molecular pathogenesis of human cancer. Affiliations and Expertise Professor, Department of Pathology and Laboratory Medicine, Curriculum in Toxicology, UNC Program in Translational Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA

Affiliations and Expertise

PhD, Professor, Department of Pathology and Laboratory Medicine, Curriculum in Toxicology, Program in Translational Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA

Gregory Tsongalis

Greg Tsongalis is the Director of the Laboratory for Clinical Genomics and Advanced Technology (CGAT) at the Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center (NCCC) in Lebanon, NH and a Professor of Pathology and Laboratory Medicine at the Audrey and Theodor Geisel School of Medicine at Dartmouth in Hanover, NH. He is a member of the NCCC Molecular Therapeutics Program and the gastrointestinal and breast cancer clinical oncology groups. In 2016 he became a member of Dartmouth College’s Program in Experimental and Molecular Medicine (PEMM), and he has served on the advisory board of the Health Care Genetics Professional Science Master’s Degree Program at the University of Connecticut (Storrs, CT). His area of expertise is in the development and implementation of clinical molecular diagnostic technologies. His research interests are in the pathogenesis of human cancers, personalized medicine and disruptive technologies. He has authored/edited twelve textbooks in the field of molecular pathology, published more than 200 peer reviewed manuscripts, and has been an invited speaker at both national and international meetings. He has served on numerous committees of the AACC, ASIP, FASEB and AMP where he is a past President. He is active in the Alliance for Clinical Trials in Oncology, the Association for Molecular Pathology, the American Association for Clinical Chemistry, the American Association of Bioanalyts, and the American Society for Investigative Pathology. He serves on the editorial boards of 8 journals including Clinical Chemistry, Experimental and Molecular Pathology, and the Journal of Molecular Diagnostics. He also serves on numerous corporate scientific advisory boards.

Affiliations and Expertise

PhD, Professor of Pathology and Laboratory Medicine, Director of Laboratory for Clinical Genomics and Advanced Technology (CGAT), Audrey and Theodor Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center, Lebanon, NH, USA