Laboratory Animal Anaesthesia

Laboratory Animal Anaesthesia

3rd Edition - April 9, 2009

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  • Author: Paul Flecknell
  • eBook ISBN: 9780080918990

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Laboratory Animal Anesthesia looks at recent significant developments in anesthetic practices in laboratory experiments involving animals. It also provides information about basic standards for proper use of anesthesia. In addition, it examines the equipment and different anesthetic agents that are used in performing an experiment on animals. The book also discusses the profound effects of anesthesia on the physiological aspect of the animals’ body systems, such as hypothermia and respiratory depression. The book addresses the proper management and care that should be provided for the animals that undergo anesthesia. Furthermore, it covers different anesthetic procedures that should be used on various kinds of small animals intended for laboratory experiments. The main goal of this book is to provide information about the different anesthetic agents used in experiments, and the proper standards to follow when using anesthetics on lab animals.

Key Features

• New edition provides new information on anesthesia and analgesia, and has an extensively revised and updated bibliography
• Provides a balanced consideration of the needs of scientific research and the welfare of laboratory animals
• Written by a veterinary anesthetist and scientist with over 30 years' experience in the field, and who is actively engaged in research in this area
• Provides rapid, easily accessed information using tabulated summaries
• Provides those with limited experience of anesthesia with the information they need to carry our procedures effectively, safely, and humanely
• Provides sufficient depth for the more experienced anesthetist moving to this field


Researchers, post docs and graduate students who utilize animals in biomedical research.

Table of Contents

  • Preface

    Preface to the Second Edition

    Preface to the First Edition


    List of Tables

    List of Figures



    1 Preparing for Anaesthesia

    Anaesthetic equipment and anaesthetic drugs

    Other equipment


    The animal

    2 Anaesthesia

    General anaesthesia

    3 Anaesthetic Management

    Pre-operative preparations

    Monitoring anaesthesia

    Anaesthetic problems and emergencies

    4 Special Techniques

    Use of neuromuscular blocking agents

    Controlled ventilation

    Long-term anaesthesia

    Anaesthesia of pregnant animals

    Anaesthesia of neonates

    Anaesthesia for imaging

    5 Analgesia and Post-operative Care

    The recovery room environment

    Problems during the recovery period

    Management of post-operative pain

    Pain assessment

    Pain relief


    6 Anaesthesia of Common Laboratory Species: Special Considerations

    Small rodents






    Sheep and goats


    Other species


    Appendix 1 Recommended Techniques and Physiological Data

    Appendix 2 Estimation of Required Quantities of Volatile Anaesthetics and Anaesthetic Gases

    Appendix 3 Examples of Dilutions of Anaesthetic Mixtures for Small Rodents

    Appendix 4 Manufacturers of Equipment and Other Items Illustrated or Cited in the Text


Product details

  • No. of pages: 304
  • Language: English
  • Copyright: © Academic Press 2009
  • Published: April 9, 2009
  • Imprint: Academic Press
  • eBook ISBN: 9780080918990

About the Author

Paul Flecknell

Paul Flecknell is a veterinarian with over 35 years of experience working with laboratory animals. He is a Diplomate of the European Colleges of Veterinary Anaesthesia and Analgesia and Laboratory Animal Medicine and an honorary Diplomate of the American College of Laboratory Animal Medicine. He has PhD in physiology, and is currently Professor of Laboratory Animal Science in the Institute of Neuroscience at Newcastle University. His main research interests are anaesthesia and analgesia of all species of animals and in particular the development of methods of pain assessment. He is the head of the Pain and Animal Welfare Science (PAWS) group at Newcastle. The group’s current research work is focussed on novel methods of “cage-side” assessment of pain, particularly using “pain faces” and developing methods of measurement of affective state in rodents.

Affiliations and Expertise

Comparative Biology Centre, The Medical School, Newcastle-Upon-Tyne, UK

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