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Laboratory Animal Anaesthesia - 3rd Edition - ISBN: 9780123693761, 9780080918990

Laboratory Animal Anaesthesia

3rd Edition

Author: Paul Flecknell
Paperback ISBN: 9781493300662
Hardcover ISBN: 9780123693761
eBook ISBN: 9780080918990
Imprint: Academic Press
Published Date: 9th April 2009
Page Count: 304
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Laboratory Animal Anesthesia looks at recent significant developments in anesthetic practices in laboratory experiments involving animals. It also provides information about basic standards for proper use of anesthesia. In addition, it examines the equipment and different anesthetic agents that are used in performing an experiment on animals. The book also discusses the profound effects of anesthesia on the physiological aspect of the animals’ body systems, such as hypothermia and respiratory depression. The book addresses the proper management and care that should be provided for the animals that undergo anesthesia. Furthermore, it covers different anesthetic procedures that should be used on various kinds of small animals intended for laboratory experiments. The main goal of this book is to provide information about the different anesthetic agents used in experiments, and the proper standards to follow when using anesthetics on lab animals.

Key Features

• New edition provides new information on anesthesia and analgesia, and has an extensively revised and updated bibliography
• Provides a balanced consideration of the needs of scientific research and the welfare of laboratory animals
• Written by a veterinary anesthetist and scientist with over 30 years' experience in the field, and who is actively engaged in research in this area
• Provides rapid, easily accessed information using tabulated summaries
• Provides those with limited experience of anesthesia with the information they need to carry our procedures effectively, safely, and humanely
• Provides sufficient depth for the more experienced anesthetist moving to this field


Researchers, post docs and graduate students who utilize animals in biomedical research.

Table of Contents


Preface to the Second Edition

Preface to the First Edition


List of Tables

List of Figures



1 Preparing for Anaesthesia

Anaesthetic equipment and anaesthetic drugs

Other equipment


The animal

2 Anaesthesia

General anaesthesia

3 Anaesthetic Management

Pre-operative preparations

Monitoring anaesthesia

Anaesthetic problems and emergencies

4 Special Techniques

Use of neuromuscular blocking agents

Controlled ventilation

Long-term anaesthesia

Anaesthesia of pregnant animals

Anaesthesia of neonates

Anaesthesia for imaging

5 Analgesia and Post-operative Care

The recovery room environment

Problems during the recovery period

Management of post-operative pain

Pain assessment

Pain relief


6 Anaesthesia of Common Laboratory Species: Special Considerations

Small rodents






Sheep and goats


Other species


Appendix 1 Recommended Techniques and Physiological Data

Appendix 2 Estimation of Required Quantities of Volatile Anaesthetics and Anaesthetic Gases

Appendix 3 Examples of Dilutions of Anaesthetic Mixtures for Small Rodents

Appendix 4 Manufacturers of Equipment and Other Items Illustrated or Cited in the Text



No. of pages:
© Academic Press 2009
9th April 2009
Academic Press
Paperback ISBN:
Hardcover ISBN:
eBook ISBN:

About the Author

Paul Flecknell

Paul Flecknell is a veterinarian with over 35 years of experience working with laboratory animals. He is a Diplomate of the European Colleges of Veterinary Anaesthesia and Analgesia and Laboratory Animal Medicine and an honorary Diplomate of the American College of Laboratory Animal Medicine. He has PhD in physiology, and is currently Professor of Laboratory Animal Science in the Institute of Neuroscience at Newcastle University. His main research interests are anaesthesia and analgesia of all species of animals and in particular the development of methods of pain assessment. He is the head of the Pain and Animal Welfare Science (PAWS) group at Newcastle. The group’s current research work is focussed on novel methods of “cage-side” assessment of pain, particularly using “pain faces” and developing methods of measurement of affective state in rodents.

Affiliations and Expertise

Comparative Biology Centre, The Medical School, Newcastle-Upon-Tyne, UK

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