Kumar and Clark's Clinical Medicine

Kumar and Clark's Clinical Medicine

10th Edition - June 19, 2020

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  • Editors: Adam Feather, David Randall, Mona Waterhouse
  • Paperback ISBN: 9780702078682
  • eBook ISBN: 9780702078705

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Description

Now in its tenth edition, Kumar & Clark’s Clinical Medicine is fully updated and revised under a new team of editors.Featuring new chapters covering: o Diagnosis: the art of being a doctor – helping readers to develop a confident clinical method in interactions with patientso Elderly medicine, frailty and multimorbidityo Public healtho Surgeryo Evidence-based medicineo Sepsis and the treatment of bacterial infection  o Haematological Oncologyo Venous thromboembolic diseaseo Hypertensiono Men’s healthEnhanced clinical skills content has been added to most chapters - helping readers tailor history-taking and examination skills to specific specialty-based contexts.Bonus online content - including self-assessment, common clinical and international cases, cardiovascular and respiratory audio material, clinical examination videos and bite-sized topic pages covering major conditions.Heavily revised throughout with smaller chapters to ease navigation, added introductions and system overviews included for most chapters.

Key Features

Edited by Adam Feather, MBBS, FRCP, FAcadMEd; David Randall, MA, MRCP; and Mona Waterhouse, MA, MRCP


Contributors comprise consultants at the top of their fields, paired with younger doctors closer to the exam experience, to ensure authority and relevance.


Enhanced e-book accompanies the print book, for ease of transportation and use on the move.


International Advisory Board, led by Professor Janaka de Silva and Professor Senaka Rajapakse, providing guidance for global coverage from across the world.


Contributions to the e-book by members of the International Advisory Board to amplify areas of clinical importance in their parts of the world.

Table of Contents

  • Instructions for online access
  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Foreword to the Tenth Edition
  • Preface to the Tenth Edition
  • Online Clinical Overviews
  • Online Special Topics
  • Online Clinical Cases
  • List of Contributors
  • International Advisory Board
  • Acknowledgements for the Tenth Edition
  • 1. Diagnosis: The art of being a doctor
  • Core Skills and Knowledge
  • Diagnosis in the Clinical Consultation
  • The medical consultation
  • Clinical diagnostic reasoning
  • Communicating a diagnosis
  • Diagnosis, artificial intelligence and the future of medicine
  • 2. Human genetics
  • Core Skills and Knowledge
  • Clinical skills for genetic medicine
  • Introduction
  • Clinical genetics
  • The cellular basis of genetics
  • Genetic disorders
  • Techniques for studying the genetic code
  • Genomic medicine
  • The genetic basis of cancer
  • 3. Immunity
  • Core Skills and Knowledge
  • Introducing the tissues, cells and molecules of the immune system
  • Innate immune system
  • Adaptive immune system
  • Cell migration
  • HLA molecules and antigen presentation
  • The immune system in concert
  • Laboratory investigations of the immune system
  • Clinical immunodeficiency
  • Allergic disease (immediate hypersensitivity)
  • Autoimmune disease
  • Organ rejection in clinical transplantation
  • Immune-based therapies
  • 4. Evidence-based practice
  • Core Skills and Knowledge
  • Introduction
  • Asking Answerable Questions
  • Searching for the Evidence
  • Appraising the Evidence
  • Applying the Evidence
  • Section 1: Asking Answerable Questions and Searching for the Evidence
  • Section 2: Critical Appraisal
  • Section 3: Interpreting Odds Ratios, Confidence Intervals and P-Values
  • Section 4: Multiple Choice Questions
  • 5. Ethical practice and clinical communication
  • Core Skills and Knowledge
  • Ethics and the law
  • Communication in medicine
  • 6. Malignant disease
  • Core Skills and Knowledge
  • Clinical skills for malignant disease
  • Introduction
  • The biology of cancer
  • Aetiology and epidemiology
  • Screening and investigations
  • Principles of cancer treatment
  • Acute oncology
  • Common solid tumour treatment
  • Lung cancer
  • Breast cancer
  • Upper gastrointestinal cancers
  • Lower gastrointestinal cancers
  • Hepatobiliary and pancreatic cancers
  • Urological cancers
  • Gynaecological cancers
  • Brain tumours
  • Head and neck cancer
  • Metastatic cancer of unknown primary
  • 7. Palliative care and symptom control
  • Core Skills and Knowledge
  • Introduction and General Aspects
  • Symptom Control
  • Palliative Care in Non-Malignant Disease
  • Care of the Dying
  • 8. Sepsis and the treatment of bacterial infection
  • Core Skills and Knowledge
  • clinical skills for infection and sepsis
  • Introduction
  • Pathophysiology
  • recognition of sepsis
  • Management of Sepsis
  • Antimicrobial Stewardship
  • Antibiotic Therapies
  • 9. Water balance, fluids and electrolytes
  • Core skills and knowledge
  • Clinical skills for water balance, fluids and electrolytes
  • Water and Electrolytes
  • Disorders of sodium concentration
  • Disorders of potassium concentration
  • Disorders of magnesium concentration
  • Disorders of phosphate concentration
  • Acid–Base Disorders
  • 10. Critical care medicine
  • Core Skills and Knowledge
  • Introduction
  • Clinical approach to the critically ill patient
  • Applied cardiorespiratory physiology
  • Disturbances of acid–base balance
  • Shock, sepsis and acute disturbances of haemodynamic function
  • Respiratory failure
  • Acute respiratory distress syndrome
  • Acute Kidney injury
  • Neurocritical care
  • Outcomes
  • 11. Surgery
  • Core Skills and Knowledge
  • Clinical skills for surgery
  • Introduction
  • The pathophysiology of surgery
  • Management of the perioperative patient
  • The patient journey in surgery
  • Surgical Ethics, Consent and the Law
  • 12. Prescribing, therapeutics and toxicology
  • Core Skills and Knowledge
  • Prescribing
  • Why do patients need drugs?
  • The choice of drug
  • The dose
  • Prescribing in special populations
  • Monitoring drug therapy
  • Adverse drug reactions
  • Drug interactions
  • Information sources
  • Poisoning
  • Clinical approach to the poisoned patient
  • Principles of management of poisoning
  • Specific poisons
  • Poisons in the natural world: additional online content
  • 13. Global health
  • Core Skills and Knowledge
  • Introduction
  • Millennium and Sustainable Development Goals
  • Global Burden of Disease
  • Poverty
  • Water and Sanitation
  • Organizations and the global health agenda
  • Education
  • Maternal and Child Health
  • Mental health
  • Accidents and Trauma
  • Conflict and Catastrophe
  • Economics and Politics in Global Health
  • Social Determinants of Health
  • Human rights and the value of engagement in global health
  • 14. Public health
  • Core Skills and Knowledge
  • Introduction
  • Key Concepts in Public Health
  • Pillars of Public Health
  • 15. Geriatric medicine, frailty and multimorbidity
  • Core Skills and Knowledge
  • Introduction
  • Ageing
  • Investigations in Older Adults
  • Taking a History
  • Multimorbidity, Sarcopenia and Frailty
  • Comprehensive Geriatric Assessment
  • Advance Care Planning
  • The Most Common Issues in Older People
  • Ageing Well and Advantages of Ageing
  • 16. Haematology
  • Core Skills and Knowledge
  • Clinical skills for haematology
  • Examination
  • Investigations
  • Introduction
  • The red cell
  • Anaemia: an introduction
  • Microcytic anaemia
  • Normocytic anaemia
  • Macrocytic anaemias
  • Anaemia due to marrow failure (aplastic anaemia)
  • Haemolytic anaemias: an introduction
  • Inherited haemolytic anaemia
  • Acquired haemolytic anaemia
  • Polycythaemia
  • The spleen
  • Blood transfusion
  • Blood groups
  • Procedure for blood transfusion in hospitals
  • Complications of blood transfusion
  • Strategies for the avoidance of unnecessary transfusion
  • Blood, blood components and blood products
  • The white cell
  • Haemostasis
  • Vascular disorders
  • Platelet disorders
  • Inherited coagulation disorders
  • Acquired coagulation disorders
  • 17. Haematological oncology
  • Core Skills and Knowledge
  • Clinical skills for haematological oncology
  • Introduction
  • Leukaemias
  • Myelodysplasia
  • Clinical features
  • Investigations
  • Management
  • MDS/MPN overlap syndromes
  • Lymphomas
  • Myeloma and other plasma cell disorders
  • 18. Rheumatology
  • Core Skills and Knowledge
  • Clinical skills for rheumatology
  • Approach to the patient
  • Anatomy and physiology of the normal joint
  • Investigation of rheumatic disease
  • Clinical conditions in rheumatology
  • Common regional musculoskeletal problems
  • Chronic pain syndromes
  • Analgesic and anti-inflammatory drugs for musculoskeletal problems
  • Disorders of collagen
  • Osteoarthritis
  • Inflammatory Arthritis
  • Rheumatoid arthritis
  • Spondyloarthritis
  • Infections of joints
  • Autoimmune rheumatic diseases
  • Systemic inflammatory vasculitis
  • Arthritis in children
  • Rheumatological problems seen in other diseases
  • Miscellaneous arthropathies
  • 19. Bone disease
  • Core Skills and Knowledge
  • Clinical skills for bone disease
  • Anatomy and physiology of bone
  • Investigation of bone and calcium disorders
  • Osteoporosis
  • Osteonecrosis
  • Paget’s disease of bone
  • Rickets and osteomalacia
  • Bone infections
  • Neoplastic disease of bone
  • Scheuermann’s disease
  • 20. Infectious disease
  • Core Skills and Knowledge
  • Core content
  • Clinical skills for infectious disease
  • Introduction
  • Clinical approach to the patient with a suspected infection
  • Epidemiology and prevention of infections
  • Principles and mechanisms of infection
  • Viral Infections
  • Virus infections of the skin and mucous membranes
  • Virus infections of the respiratory tract
  • Systemic viral infections
  • Virus infections of the nervous system
  • Virus infections of the gastrointestinal tract
  • Viral hepatitis
  • Viruses and malignant disease
  • Viral haemorrhagic fevers
  • Antiviral drugs
  • Transmissible Spongiform Encephalopathies (Prion Diseases)
  • Bacterial Infections
  • Bacterial infections of the skin and soft tissues
  • Bacterial infections of the respiratory tract
  • Bacterial infections of the gastrointestinal tract
  • Bacterial infections of the cardiovascular system
  • Bacterial infections of the nervous system
  • Bacterial bone and joint infections
  • Bacterial infections of the urinary tract
  • Systemic/multisystem bacterial infections
  • Bacterial infections seen in developing and tropical countries
  • Antibiotic therapies
  • Fungal Infections
  • Systemic fungal infections
  • Subcutaneous fungal infections
  • Superficial fungal infections
  • Antifungal drugs
  • Protozoal Infections
  • Blood and tissue protozoa
  • Gastrointestinal protozoa
  • Helminthic Infections
  • Nematodes
  • Trematodes
  • Cestodes
  • Arthropod Ectoparasites
  • 21. Endocrinology
  • Core Skills and Knowledge
  • Clinical skills for endocrinology
  • Introduction
  • The pituitary gland and hypothalamus
  • Hypothalamo–Pituitary–adrenal axis
  • The thyroid axis
  • Hypothalamo–pituitary–gonadal axis
  • Growth and puberty
  • The Thirst Axis
  • Disorders of Calcium Metabolism
  • Hypoglycaemia in the non-diabetic patient
  • Other endocrine disorders
  • 22. Dermatology
  • Core Skills and Knowledge
  • Clinical Skills for Dermatology
  • Introduction
  • Skin structure and function
  • Investigation of Skin Disease
  • Principles of Dermatological Therapy
  • Erythroderma and Loss of Skin Function (‘Skin Failure’)
  • Common rashes
  • Skin Infections
  • Human Immunodeficiency Virus and the Skin
  • Skin Signs of Systemic Disease
  • Photosensitivity
  • Blistering and Bullous Skin Disease
  • Skin Tumours
  • Disorders of Pigmentation
  • Nail Disorders
  • Hair Disorders
  • Birth Marks and Neonatal Rashes
  • Drug Eruptions
  • 23. Diabetes mellitus
  • Core Skills and Knowledge
  • Clinical skills for diabetes mellitus
  • Introduction
  • Physiology of insulin structure, secretion and action
  • Classification of diabetes
  • Clinical Approach to the Patient With Diabetes
  • Prevention of Type 2 Diabetes
  • Management of diabetes
  • Diabetic metabolic emergencies
  • Complications of diabetes
  • Psychosocial Implications of Diabetes
  • Diabetes in special situations
  • Organization of diabetes care
  • 24. Lipid and metabolic disorders
  • Core Skills and Knowledge
  • Introduction
  • History
  • Examination
  • Investigations
  • Disorders of lipid metabolism
  • Inherited metabolic diseases
  • 25. Liaison psychiatry
  • Core Skills and Knowledge
  • Introduction
  • Clinical approach to the patient with a psychiatric disorder
  • Classification of psychiatric disorders
  • Aetiology of psychiatric disorders
  • Psychiatric aspects of physical diseases
  • Sick role and illness behaviour
  • Functional somatic syndromes
  • Somatoform disorders
  • Dissociative/conversion disorders
  • Sleep difficulties
  • Mood (affective) disorders
  • Suicide and self-harm
  • Anxiety disorders
  • Alcohol misuse and dependence
  • Drug misuse and dependence
  • Schizophrenia
  • Organic mental disorders
  • Eating disorders
  • Sexual disorders
  • Personality disorders
  • Involuntary Detention
  • Mental Capacity Act
  • 26. Neurology
  • Core Skills and Knowledge
  • Clinical skills for neurology
  • Introduction
  • Clinical approach to the patient with neurological disease
  • Functional neuroanatomy
  • Cranial nerves
  • Motor control systems
  • Lower motor neurone lesions
  • Sensory pathways and pain
  • Bladder control and sexual dysfunction
  • Investigation of neurological disease
  • Unconsciousness and coma
  • Stroke
  • Intracranial haemorrhage
  • Headache, migraine and facial pain
  • Epilepsy and loss of consciousness
  • Movement disorders
  • Neuroinflammatory disorders
  • Nervous system infection
  • Hydrocephalus
  • Traumatic brain injury
  • Spinal cord disease
  • Neurodegenerative diseases
  • Congenital disorders
  • Neurogenetic disorders
  • Paraneoplastic syndromes
  • Peripheral nerve disease
  • Muscle diseases
  • 27. Ear, nose and throat and eye disease
  • Core Skills and Knowledge
  • Introduction to ENT
  • Clinical approach to the patient with an ENT complaint
  • Disorders of the Ear
  • Clinical Approach to the Patient With a Disorder of the Ear
  • Common disorders of the ear
  • Disorders of the Nose
  • Clinical Approach to the Patient With a Disorder of the Nose
  • Common disorders of the nose
  • Disorders of the Throat
  • Clinical Approach to the Patient With a Disorder of the Throat
  • Common disorders of the throat
  • Disorders of the Eye
  • Applied Anatomy and Physiology
  • Clinical Approach to the Patient With a Disorder of the Eye
  • Common disorders of the eye
  • 28. Respiratory disease
  • Core Skills and Knowledge
  • Clinical skills for respiratory medicine
  • Function of the respiratory system
  • Clinical Approach to the Patient with Respiratory Disease
  • Diseases of the Upper Respiratory Tract
  • Obstructive Respiratory Disease
  • Smoking
  • Respiratory Infection
  • Pleural Disease
  • Tumours of the Respiratory Tract
  • Bronchiectasis
  • Interstitial Lung Diseases
  • Lung and Heart–Lung Transplantation
  • Occupational Lung Disease
  • Miscellaneous Respiratory Disorders
  • Disorders of the Diaphragm
  • Mediastinal Lesions
  • 29. Venous thromboembolic disease
  • Core Skills and Knowledge
  • Introduction
  • Pathogenesis of Thrombosis
  • Definitions
  • Epidemiology and Risk Factors
  • Clinical Features
  • Diagnosis
  • Management
  • Complications
  • Investigation of newly diagnosed venous thrombosis
  • Prevention
  • Anticoagulant agents
  • 30. Cardiology
  • Core Skills and Knowledge
  • Clinical skills for cardiology
  • ECG interpretation
  • Anatomy, physiology and embryology of the heart
  • Clinical approach to the patient with heart disease
  • Therapeutic procedures
  • Cardiac arrhythmias
  • Bradycardias and heart block
  • Supraventricular tachycardias
  • Ventricular tachyarrhythmias
  • Heart failure
  • Coronary artery disease
  • Angina
  • Acute coronary syndromes
  • Valvular heart disease
  • Aortic valve
  • tricuspid valve
  • Pulmonary valve
  • Prosthetic valves
  • Infective endocarditis
  • Congenital heart disease
  • Marfan’s syndrome
  • Pulmonary heart disease
  • Myocardial and endocardial disease
  • Myocardial disease
  • Pericardial disease
  • Peripheral vascular disease
  • Peripheral venous disease
  • 31. Hypertension
  • Core Skills and Knowledge
  • Introduction
  • Clinical Approach to the Patient with Hypertension
  • Measurement of blood pressure
  • Phenotypes of Hypertension
  • Causes of raised blood pressure
  • Thresholds and Targets In Hypertension
  • Hypertensive Target Organ Damage
  • Treatment
  • Managing blood pressure in hospital
  • 32. Gastroenterology
  • Core Skills and Knowledge
  • Clinical Skills for Gastroenterology
  • INTRODUCTION
  • Anatomy and physiology of the gastrointestinal tract
  • Investigation of Gastrointestinal Disease
  • Functional Gastrointestinal Disorders
  • Mouth
  • Salivary Glands
  • Pharynx and Oesophagus
  • Stomach and Duodenum
  • Acute and Chronic Gastrointestinal Bleeding
  • Small Intestine
  • Inflammatory Bowel Disease
  • Colon and Rectum
  • The Acute Abdomen
  • Peritoneum
  • 33. Nutrition
  • Core Skills and Knowledge
  • Introduction
  • Water and Electrolyte Balance
  • Dietary Requirements
  • Protein–Energy Malnutrition
  • Vitamins
  • Fat-soluble vitamins
  • Water-soluble vitamins
  • Dietary Antioxidants
  • Homocysteine, cardiovascular disease and B vitamins
  • Minerals
  • Nutrition and Ageing
  • Obesity
  • Nutritional Support
  • Food Allergy and Food Intolerance
  • Alcohol
  • 34. Liver disease
  • Core Skills and Knowledge
  • Clinical skills for liver disease
  • Introduction
  • Anatomy of the liver and biliary system
  • Functions of the liver
  • Investigations in the patient with liver disease
  • Jaundice
  • Hepatitis
  • Acute hepatic failure
  • Autoimmune hepatitis
  • Drug-induced chronic hepatitis
  • Chronic hepatitis of unknown cause
  • Non-alcoholic fatty liver disease
  • Cirrhosis
  • Alcoholic liver disease
  • Budd–chiari syndrome
  • Hepatic sinusoidal obstruction syndrome
  • Fibropolycystic diseases
  • Liver abscess
  • Other infections of the liver
  • Liver disease in pregnancy
  • Liver tumours
  • Miscellaneous conditions of the liver
  • Drugs and the liver
  • 35. Biliary tract and pancreatic disease
  • Core Skills and Knowledge
  • Introduction
  • Gall Bladder and Biliary System
  • Biliary system
  • Miscellaneous conditions of the biliary tract
  • Pancreas
  • Pancreatitis
  • Pancreatic cancer
  • Pancreatic neuroendocrine tumours
  • Clinical syndromes
  • Investigations
  • Management
  • 36. Kidney and urinary tract disease
  • Core Skills and Knowledge
  • Clinical Skills for Nephrology
  • Examination
  • Introduction
  • Anatomy and Physiology of the Kidney and Urinary Tract
  • Investigation of Renal and Urinary Tract Disease
  • The Glomerulus and Glomerular Disease
  • Kidney Involvement in Other Diseases
  • Hypertension and the Kidney
  • Other Vascular Disorders of the Kidney
  • Renal Calculi and Nephrocalcinosis
  • Urinary Tract Obstruction
  • Drugs and the Kidney
  • Urinary Tract Infection
  • Tubulointerstitial Nephritis
  • Acute Kidney Injury
  • Chronic Kidney Disease
  • Cystic Renal Disease
  • Tumours of the Kidney and Genitourinary Tract
  • Diseases of the Prostate Gland
  • The Urinary Tract in the Elderly
  • 37. Sexually transmitted infections and human immunodeficiency virus
  • Core Skills and Knowledge
  • Clinical skills for STI and HIV care
  • Sexually transmitted infections
  • Asymptomatic STI screening
  • Investigation of STIs
  • Management, prevention and control
  • Specific infections
  • Human immunodeficiency virus and acquired immunodeficiency syndrome
  • Clinical features of untreated hiv infection
  • Clinical approach to the patient with HIV
  • Management of HIV-positive patients
  • Specific conditions associated with HIV infection
  • Prevention and control of HIV infection
  • 38. Obstetric medicine
  • Core Skills and Knowledge
  • Clinical Skills for Obstetric Medicine
  • Introduction
  • Hypertensive Disorders
  • Liver Disease
  • Cardiac Disease
  • Thromboembolic Disease
  • Respiratory Disease
  • Neurological Disease
  • Endocrine Disease
  • Renal Disease
  • Skin Disorders
  • RHEUMATIC DISEASE
  • Prescribing in Pregnancy
  • 39. Women’s health
  • Core Skills and Knowledge
  • Clinical skills for women’s health
  • Introduction
  • The life course approach
  • Miscarriage
  • Heavy Menstrual Bleeding
  • Abortion/Termination of Pregnancy
  • Urinary Incontinence
  • Domestic abuse and violence
  • Gynaecological cancers
  • 40. Men’s health
  • Core Skills and Knowledge
  • Clinical Skills For Men’s Health
  • Introduction
  • Specific Diseases of Men
  • Diseases of the prostate gland
  • Diseases of the Penis
  • Testicular and Spermatic Cord Disease
  • Lack of Libido and Erectile Dysfunction
  • Priapism
  • The Ageing Male
  • 41. Environmental medicine
  • Core Skills and Knowledge
  • Air pollution
  • Heat Injury
  • Cold injury
  • High altitude
  • Diving
  • Drowning
  • Ionizing radiation
  • Electric shock
  • Lightning strike
  • Inhaled smoke
  • Index
  • Normal Values

Product details

  • No. of pages: 1564
  • Language: English
  • Copyright: © Elsevier 2020
  • Published: June 19, 2020
  • Imprint: Elsevier
  • Paperback ISBN: 9780702078682
  • eBook ISBN: 9780702078705

About the Editors

Adam Feather

Affiliations and Expertise

Consultant Physician and Clinical Director, St Mary's Hospital, The Isle of Wight

David Randall

Mona Waterhouse

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