1st Edition - April 25, 2016

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  • Editor: Gerald Litwack
  • Hardcover ISBN: 9780128048191
  • eBook ISBN: 9780128052358

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Klotho is the latest edition of a series first published in 1943 on Vitamins and Hormones and the longest-running serial published by Academic Press. It provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic, with volumes focusing on a single molecule or on a disease that is related to vitamins or hormones that are interpreted broadly so that related substances, such as transmitters, cytokines, growth factors, and others can be reviewed.

Key Features

  • Contains contributions from experts in the field of vitamins and hormones
  • Covers a vast array of subjects
  • In-depth, current information at the molecular to clinical levels


Researchers, faculty, and graduate students interested in cutting-edge reviews concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested.

Table of Contents

  • 1. Klotho-Related Protein KLrP: Structure and Functions
    Yasuhiro Hayashi and Makoto Ito
    2. The FGF21 Receptor Signaling Complex: KLOTHO, FGFR1c and Other Regulatory Interactions
    Dawn M. Kilkenny and Jonathan V. Rocheleau
    3. Klotho-Dependent Cellular Transport Regulation
    Mentor Sopjani and Miribane Dërmaku-Sopjani
    4. Klotho and the Growth Hormone/Insulin-like Growth Factor 1 Axis: Novel Insights Into Complex Interactions
    Tami Rubinek and Dalit Modan-Moses 
    5. Klotho Prevents Translocation of NFκB
    Paula Buendía, Rafael Ramírez, Pedro Aljama and Julia Carracedo
    6. The FGF23/KLOTHO Regulatory Network and its Roles in Human Disorders
    Saori Kinoshita and Masanobu Kawai
    7. MicroRNA-34a and Impaired FGF19/21 Signaling in Obesity
    Ting Fu and Jongsook Kim Kemper
    8. The Role of Alpha-Klotho as a Universal Tumor Suppressor
    Tami Rubinek and Ido Wolf
    9. Klotho is a Neuroprotective and Cognition-Enhancing Protein
    Carmela R. Abraham, Patrick C. Mullen, Tracey Tucker Zhou, Cidi Chen and Ella Zeldich
    10. Function and Change with Aging of α-Klotho in the Kidney
    Keiko Akasaka-Manya, Hiroshi Manya and Tamao Endo
    11. αKlotho and Chronic Kidney Disease
    Javier A. Neyra  and Ming Chang Hu
    12. Deficiency of Soluble α-Klotho as an Independent Cause of Uremic Cardiomyopathy
    Jian Xie, Yueh-Lin Wu and Chou-Long Huang

Product details

  • No. of pages: 352
  • Language: English
  • Copyright: © Academic Press 2016
  • Published: April 25, 2016
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128048191
  • eBook ISBN: 9780128052358

About the Serial Editor

Gerald Litwack

Gerald Litwack
Dr. Gerald Litwack obtained M.S. and PhD degrees from the University of Wisconsin Department of Biochemistry and remained there for a brief time as a Lecturer on Enzymes. Then he entered the Biochemical Institute of the Sorbonne as a Fellow of the National Foundation for Infantile Paralysis. He next moved to Rutgers University as an Assistant Professor of Biochemistry and later as Associate Professor of biochemistry at the University of Pennsylvania Graduate School of Medicine. After four years he moved to the Temple University School of Medicine as Professor of Biochemistry and Deputy Director of the Fels Institute for Cancer Research and Molecular Biology, soon after, becoming the Laura H. Carnell Professor. Subsequently he was appointed chair of Biochemistry and Molecular Pharmacology at the Jefferson Medical College as well as Vice Dean for Research and Deputy Director of the Jefferson Cancer Institute and Director of the Institute for Apoptosis. Following the move of his family, he became a Visiting Scholar at the Department of Biological Chemistry of the Geffen School of Medicine at UCLA and then became the Founding Chair of the Department of Basic Sciences at the Geisinger Commonwealth School of Medicine, becoming Professor of Molecular and Cellular Medicine and Associate Director of the Institute for Regenerative Medicine at the Texas A&M Health Science Center as his final position. During his career he was a visiting scientist at the University of California, San Francisco and Berkeley, Courtauld Institute of Biochemistry, London and the Wistar Institute. He was appointed Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine. He has published more than 300 scientific papers, authored three textbooks and edited more than sixty-five books. Currently he lives with his family and continues his authorship and editorial work in Los Angeles.

Affiliations and Expertise

Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine, USA; Toluca Lake, North Hollywood, California, USA

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