Key Heterocycle Cores for Designing Multi-targeting Molecules - 1st Edition - ISBN: 9780081020838

Key Heterocycle Cores for Designing Multi-targeting Molecules

1st Edition

Authors: Om Silakari
Paperback ISBN: 9780081020838
Imprint: Elsevier
Published Date: 1st August 2018
Page Count: 410
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Key Heterocycle Cores for Designing Multi-targeting Molecules provides a helpful overview of current developments in the field. Following a detailed introduction to the manipulation of heterocycle cores for the development of dual or multi-targeting molecules, the book goes on to describe specific examples of such developments, focusing on compounds such as Benzimidazole, Acridine, Flavones, Thiazolidinedione and Oxazoline. Drawing on the latest developments in the field, this volume provides a valuable guide to current approaches in the design and development of molecules capable of acting on multiple targets.

Adapting the heterocyclic core of a single-target molecule can facilitate its development into an agent capable of acting on multiple targets. Such multi-targeting drugs have the potential to become essential components in the design of novel, holistic treatment plans for complex diseases, making the design of such active agents an increasingly important area of research.

Key Features

  • Emphasizes the chemical development of heterocyclic nuclei, from single to multi-targeting molecules
  • Provides chapter-by-chapter coverage of the key heterocyclic compounds used in synthesizing multi-targeting agents
  • Outlines current trends and future developments in multi-target molecule design for the treatment of various diseases


Organic, heterocyclic, computational and medicinal chemists working in both academia and industry, as well as drug discovery researchers in related fields

Table of Contents

1. Multi-targeting heterocycles an improved and rational chemical probes for multifactorial diseases
2. Benzimidazole: journey from a single targeting to a multitargeting nucleus
3. Acridines: a relatively lesser explored heterocycle for multifactorial diseases
4. Flavones: chemical moiety with vast putative multitargeting potential
5. Thiazolidinedione: potential weapon for targeting multiple pathological condition
6. Oxindole: nucleus possessing variety of therapeutic benefits
7. Thiazines: a versatile heterocyclic scaffold for multifactorial diseases
8. Indoles: An under-recognized heterocycle with vast pharmacological potential
9. Triazoles: multidimensional 5-membered nucleus for designing multitargeting agents
10. Benzoxazolinone: a scaffold with diverse pharmacological significance
11. Benzotriazole: An outlook as multi-targeting agents


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© Elsevier 2018
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About the Author

Om Silakari

Dr. Om Silakari is an assistant professor in the Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India. He received his Ph.D. degree from Dr. Hari Singh Gour University, India and has been teaching and researching in this area for over 10 years. His research areas include computer-assisted drug designing (CADD) of new anti-inflammatory, antidiabetic and anticancer targets, and the synthesis of new lead molecules. In addition to supervising multiple M. Pharm. and PhD students, he has authored two books and published over 60 papers in international journals. Dr Silakari is an active reviewer for many international journals, has been awarded funding for several research projects, and regularly delivers talks at both national and international conferences.

Affiliations and Expertise

Om Silakari, Assistant Professor, Department of Pharmaceutical Sciences and Drug Research, Punjab University, India

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