Joll's Diseases of the Thyroid Gland - 2nd Edition - ISBN: 9781483168104, 9781483195582

Joll's Diseases of the Thyroid Gland

2nd Edition

Authors: Francis F. Rundle
eBook ISBN: 9781483195582
Imprint: Butterworth-Heinemann
Published Date: 1st January 1951
Page Count: 530
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Description

Joll's Diseases of the Thyroid Gland, Second Edition provides information pertinent to the fundamental aspects of thyroid diseases. This book discusses the physiology structure, and development of the thyroid gland. Organized into 29 chapters, this edition begins with an overview of the function of the thyroid gland to trap and concentrate iodine, harness it in organic combination, and then to secrete it into the blood. This text then discusses the evolutionary scheme showing the development of thyroid gland as a special organ for the control of iodine metabolism. Other chapters consider the various types of thyroid diseases, including simple goiter, acute inflammations, Grave's disease, and granulomatous diseases of the thyroid. This book discusses as well the etiological or clinico-pathological basis of the classification of simple goiter. The final chapter deals with the post-operative complications of thyroidectomy and their treatment. This book is a valuable resource for physicians, surgeons, and clinical researchers.

Table of Contents


Chapter I.—Histo-Physiology of the Thyroid Gland

The Thyroid Follicle

The Endogenous Iodine Cycle

Iodide Uptake

Hormone Synthesis

The Thyroglobulin Compartment

The Definitive Secretion of the Follicle

Radio-Iodine Uptake and Clearance as Indicators of Thyroid Function

Regulation of Thyroid Secretion

Pituitary Thyrotropic

Hormone in Health and Disease

Thyrotropic Hormone in the Blood

Iodine Absorption and Excretion

The Role of the Liver in the Endogenous Iodine Cycle

The modus operandi of the Thyroid Hormone

Dosage and Activity of Thyroxine

Thyroid Hormone and Tissue Oxidations

II.—Structure and Development of the Thyroid Gland

Comparative anatomy

Embryology

Anatomy

Micro-anatomy

III.—Classification of Thyroid Diseases

IV.—Simple Goitre

Definition

Classification

Mechanism of Simple Goitre Formation

Iodine deficiency

Geographical Distribution

Relationship of Adolescent to Established Goitre

Sporadic or Residual Goitre

Diet

Aetiological Role of infections

Geology

Mineralogy and Soil in Relation to Goitre

Heredity

Social Status and Occupation.

V.—Simple Goitre—Pathology

Parenchymatous Goitre

Colloid Goitre

Nodular Goitre

Radioiodine

Studies of Thyroid Nodules

Single Adenomata

Thyroid Cysts

Degeneration Cysts

Retention Cysts

Chemistry of Simple Goitre

Pathological Anatomy.

VI.—Simple Goitre—Clinical Features

Clinical Features

Pressure Signs

Cough

Stridor

Alterations in Voice

Pressure on Oesophagus

Dysphagia

Pressure on Arteries, Veins, Nerves

Recurrent Laryngeal Paralysis: Sympathetic, Vagus, Cervical or Brachial Plexus

Methods of Examination of Thyroid Enlargements

Size

Examination of other Structures in the Neck

Consistency

Mobility of the Tumour

Movements on Deglutition

Skiagraphy in Simple Goitre

Functional Tests in simple Goitre.

VII.—Special Types of Simple Goitre—Treatment of Simple Goitre

General Phenomena associated with Simple Endemic Goitre

Simple Goitre associated with Acute Dyspnoea

Simple Goitre and Pregnancy

Intrathoracic Goitre

Intrathoracic Goitre proper

Mediastinal Goitre

Goitre Plongeant

Substernal Goitre

Mechanism of Production of Intrathoracic Goitres

Pathological Anatomy

Incidence

Age and Sex

Signs and Symptoms

Dyspnoea

Diagnosis of Intrathoracic Goitre

Prognosis and Treatment

Prophylaxis of Simple Goitre

Iodine as a Prophylactic

Methods of Prophylaxis

Dangers of Iodine Prophylaxis and Treatment

Thyroid Preparations and the Treatment of Simple Goitre

Radiation Treatment of Simple Goitre

The Surgical Treatment of Simple Goitre

Single Adenomata or cysts

Prophylactic Operations on Thyroid Adenomata

Cosmetic Indication for Operation on Simple Goitre

VIII.—The Hypothyroid States

Classification of Cretinism

Aetiology

Pathology of Thyroid Gland

Systemic Effects

Skeletal Changes in Cretinism

Diagnosis

Clinical Course and Prognosis

Myxoedema

Definition and Types

Spontaneous Myxoedema

Pathology of the Thyroid Gland

Systemic Effects of Myxoedema

The Tissue Changes

Contrast with Thyrotoxicosis

Cutaneous Lesions in Myxoedema —

Postoperative Myxoedema

Pituitary Myxoedema

Latent Hypothyroidism

Mixed Endocrinopathies, including Myxoedema

Diagnosis, Prognosis and Treatment of Myxoedema

IX.—Graves" Disease — Types — Nature — Nomenclature —History

X.—Thyrotoxicosis: Nature and Clinical Factors in Its Aetiology and Pathogenesis

Nature of Thyrotoxicosis

Geographical Distribution

Antecedent Goitre

Climatic Factors

Urban and Rural Influences

Prevalence

Sex Incidence

Age of Onset

Heredity

Constitutional Predisposition

The Autonomie Nervous System and Toxic Goitre

The Sympathetico

Adrenal System and Thyrotoxicosis

Has Thyrotoxicosis a Thyroid or Extra-Thyroid Origin?

What has Thiouracil taught us concerning Pathogenesis?

Significance of the Thyroid Stump

Dietary Influences

Neurogenic

Psychic Trauma

Infectious Disease and Toxaemia

XI.—The Thyroid Gland in Thyrotoxicosis

Toxic Diffuse Goitre: Pathological Anatomy

Histology

Effect of Therapeutic Agents

Thiouracil

Toxic Nodular Goitre

Lymphoid Hyperplasia

Clinical Features.

XII.—The Cardiovascular System in Thyrotoxicosis

Disordered Physiology of the Circulation

Pathological Anatomy and Histology of the Heart

Does Heart Failure occur if Thyrotoxicosis is uncomplicated by organic disease of the heart?

Clinical Features of the Heart and Vascular System

Thyrotoxicosis plus Hypertensive Heart Disease

Thyrotoxicosis and Arteriosclerosis

Rheumatic Heart Disease and Thyrotoxicosis

Pulmonary Heart Disease and Thyrotoxicosis

Syphilitic Heart Disease and Thyrotoxicosis

Arrhythmias in Thyrotoxicosis

The Electrocardiogram

Radiological Aspects of the Heart.

XIII.—The Nervous System in Thyrotoxicosis

Nervous Manifestations produced by Thyrotoxicosis

Hyperexcitability

Changes in Personality

Cycloid and Schizoid Tendencies

Toxic Confusional States — Neurosis and Psychoneurosis associated with Thyrotoxicosis

Organic Reaction-types of Mental Disorder associated with Thyrotoxicosis.

XIV.—Other Systems in Thyrotoxicosis

Skeletal Muscles in Graves" Disease

Skeletal Changes in Thyrotoxicosis

Ovarian, Adrenal, and Pancreatic Changes

The Thymus and Lymph Glands

Pathology of the Liver

Changes in the Blood Picture

Cutaneous Manifestations of Thyrotoxicosis

XV.—The Ocular Manifestations of Graves" Disease

Historical Sketch

Definitions and Anatomy of Exophthalmos

Bulging of the Lids

Diagnosis and Varieties of Exophthalmos

Retraction of the Lids — Ophthalmoplegia

Morbid Anatomy and Histology of the Retro

Bulbar Tissues

Ophthalmic forms

Natural History of the Ocular Changes

Effect of Thyroidectomy on the Ocular Changes

Pathogenesis of the Eye Changes

Treatment of Malignant Exophthalmos.

XVI.—Biochemical Abnormalities in Thyroid Disease

Introduction

Basal Metabolism

Method of Estimation

Sources of Error

Normal Limits

Values in Disease

Serum Cholesterol Estimations

Blood Iodine Estimations

Liver Function Tests

Miscellaneous Metabolic Changes.

XVII.—The Treatment of Thyrotoxicosis

Prophylaxis

Control of Hyperthyroidism

Principles of Treatment

Management of Patients

Effect of Iodine on the Toxic Gland after Anti-thyroid Therapy

Definitive Anti-thyroid Therapy

Drug Reactions

Clinical Manifestations of Anti-thyroid-Drug Sensitivity —Pathology of Drug Reactions

Treatment of Drug Reactions — Treatment of Special

Clinical Groups

Radio-Iodine Therapy.

XVIII.—Developmental Anomalies of the Thyroid Gland

Classification of Congenital Anomalies.

XIX.—Acute Inflammations of the Thyroid Gland

Suppurative and Non-Suppurative Varieties

Strumitis

Thyroiditis

Incidence

Causes

Routes of Entry of Micro-Organisms

Bacteriology

Morbid Anatomy

Microscopical appearances

Clinical Features

Special Types

Differential Diagnosis

Prognosis and Sequelae

Treatment

Illustrative Cases.

XX.—Granulomatous Diseases of the Thyroid Gland

XXI.—Struma Lymphomatosa (Hashimoto"s Disease), Riedel"s Struma and Subacute (Pseudo-Tuberculous or Giant-Cell) Thyroiditis

Historical Summary

Differentiation from Riedel"s Struma

Incidence

Age Incidence

Sex Incidence

Geographical Distribution

Pathological Anatomy

Comparison with Riedel"s and Allied Disorders

Morbid Histology

Pathogenesis and Aetiology

Clinical Features of Hashimoto"s Struma

Diagnosis

Treatment

Prognosis.

XXII.—Malignant Disease of the Thyroid Gland

Incidence

Age

Pathology

Iodine Content of Malignant Goitre

Classification of Malignant Neoplasms

Papillary Carcinoma

Adenocarcinoma

Highly Malignant Forms

Lateral Aberrant Thyroid

Rare Forms

Metastatic Tumours

Metastases from the Thyroid

Diagnosis of Malignant Tumours

Differential Diagnosis

Prognosis

Treatment

Benign Neoplasms

XXIII.—Hydatid (Echinococcus) Disease of the Thyroid Gland

Pathology

Clinical Features

Prognosis

Treatment.

XXIV.—Amyloid Goitre

XXV.—Anaesthesia for Goitre Operations

Introduction

Examination of Patient : Operative Risk

Premedication

Stealing the Thyroid

Local Anaesthesia

Infiltration

Cervical

Plexus Block

General Anaesthesia

Intubation.

XXVI.—The Operation of Thyroidectomy for Thyrotoxicosis

Principles and Practice of Thyroidectomy

Revisor"s Preliminary Note

Certain Points in the Technique of Resection for Recurrent Thyrotoxicosis

Position of Surgeon and Assistants

Instruments

Incision

Division of Infrahyoid Muscles

Separation of Muscles

Ligation of Middle Thyroid Veins

Dislocation of Lateral Lobe

Ligation of Inferior Thyroid Artery of Inferior Veins

Continuation on right side

Resection of Gland Tissue

Completion of Haemostasis

Thermo-electric Methods

Wedge-resection

Testing Haemostasis

Closure of Wound

D.ainage —Dressings.

XXVII.—Technique of Operations for Non-Toxic Goitre

Operations for Single Adenomata and Cysts

Steps of the Operation of Resection-Enucleation

Operations for Colloid Goitre

Operations for Intrathoracic Goitre

Operations for Malignant Goitre

Operations for Chronic Thyroiditis: Tuberculous

Syphilitic

Riedel"s Disease

Lymphadenoid Goitre

Operation for Acute Thyroiditis.

XXVIII.—Dangers and Difficulties During Thyroidectomy: Usual Post-Operative Course and Management

Errors on the Operation-table

Haemorrhage

Injuries to Trachea and Oesophagus

Tracheal Collapse

Injuries to Pleura

Air Embolism

Wounds of Cervical Sympathetic, Vagus and Hypoglossal Nerves, and Thoracic Duct

Post-operative Course and Progress

Post-Operative Treatment.

XXIX.—Post-Operative Complications and Their Treatment

Prophylaxis

Acute Crises

Haemorrhage

Cyanosis

Embolism

Respiratory Complications

Wound Infections

Tetany: Treatment

Cachexia Strumipriva

Symptoms

Treatment: Laryngeal Paralyses

Treatment: Injuries to Cervical Sympathetic Trunk—Imperfections of Scar —

Swelling of Face

Index

Details

No. of pages:
530
Language:
English
Copyright:
© Butterworth-Heinemann 1951
Published:
Imprint:
Butterworth-Heinemann
eBook ISBN:
9781483195582

About the Author

Francis F. Rundle

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