Japanese Kampo Medicines for the Treatment of Common Diseases

Japanese Kampo Medicines for the Treatment of Common Diseases - Focus on Inflammation provides researchers and clinicians with a current look at how Kampo medicines can be used to effectively treat inflammatory disorders. Japanese Kampo medicines are a mixture of natural and herbal medicines that are available in Japan for the treatment of various diseases. Given their therapeutic potential, they are often prescribed instead of, or alongside, allopathic medicines.

Kampo medicines are becoming more widespread and have proven effective for the treatment of a variety of inflammatory diseases, such as colitis, dermatitis, myocarditis, hepatitis, cardiomyopathy, and nephritis. This book offers background on Japanese Kampo medicines, along with a compilation of the published scientific data for several different types of Kampo medicines. It is an evidence-based guide for all those involved in, or interested in, the research and practice of Kampo medicine.

• Includes both preclinical and clinical data published from a variety of sources and compiled into one book
• Provides insight for researchers and clinicians on which Kampo medicines will provide the least side effects and offer the most effective therapy for a particular illness
• Offers important data that will help to inform future research and widen practice in this area

Researchers and clinicians involved in natural products research including clinical pharmacologists and pharmacy students

Chapter 1. Introduction to Japanese Kampo Medicines

• Introduction
• Japanese Kampo Medicine
• History of Kampo Medicine
• Therapeutic Policy of Kampo Medicine
• Clinical Applications of Kampo Medicine
• Research
• Current Usage of Kampo and Applications in Western Medicine
• Conclusion

Chapter 2. Kampo Medicine for Human Homeostasis

• Three Roots of Eastern Traditional Medicine
• Kampo Medicine
• Sho: The Patient’s Constitution
• The Five Elements
• Yin (In) and Yang (Yo)
• How to Use Kampo Medicine: An Example Using Kakkonto
• Conclusion

Chapter 3. General Mechanisms of Immunity and Inflammation

• Introduction
• Definition of Inflammation
• Inflammatory Stimuli
• Immune System
• Mechanisms of Adaptive Immune Function
• Cytokines and Chemokines
• Immunoglobulins
• Signaling Processes in Inflammation and Immunity
• Conclusion

Chapter 4. Antioxidant Property Is the Basic Feature of Kampo Medicine

• Introduction
• Oxidative Stress and Diseases
• Oxidative Stress as the Target of Kampo Medicine
• Antioxidant Properties of Kampo Formulas and Herbal Components
• The Brain Is a Primary Target of Antioxidant Kampo Medicines
• Single Antioxidant Molecules Have Multiple Functions in a Formula
• Is an Herbal Mixture More Beneficial for Antioxidant Protection?
• Conclusion and Remarks

Chapter 5. Japanese Kampo Medicines for Inflammatory Bowel Disease

• Introduction
• Kampo Medicines for Gastrointestinal Disorders
• Inflammatory Bowel Disease
• Kampo Medicines for Inflammatory Bowel Disease
• Conclusion

Chapter 6. Significance of Japanese Kampo Medicine in Supportive Care of Heart Failure/Function

• Historical Background: Japanese Traditional Herbal Medicine (Kampo Medicine)
• Conclusion

Chapter 7. Kampo Medicine for Hypertension and Related Disorders

• Background
• Hypertension
• Kampo Medicine Used in Hypertension
• Clinical Application
• Kampo in Health Care
• Conclusion

Chapter 8. Japanese Kampo Medicines for Diabetes Mellitus

• Introduction
• Conclusion

Chapter 9. Japanese Kampo Medicine for Aging-Related Neurological Diseases

• Introduction
• Role of Kampo in Age-Related Brain Disorders
• Kampo Medicine in Dementia
• Kampo Medicines in Depression
• Kampo Medicine in Anxiety
• Preclinical Studies
• Kampo Medicine in Working and Spatial Memory
• Kampo Medicine in Alzheimer’s Disease
• Kampo Medicine in Other Neuropsychiatric Diseases
• Conclusion

Chapter 10. Antiinflammatory Effects of Kampo Medicines in Atopic Dermatitis

• Introduction
• Possible Mechanisms Underlying the Pathogenesis of Atopic Dermatitis

Chapter 11. Japanese Kampo Medicine for Hepatic Inflammation

• Introduction
• Daikenchuto
• Shosaikoto
• Keishibukuryogan
• Juzentaihoto
• Ninjinyoeito
• Inchinkoto
• Others
• Caution

Chapter 12. Kampo Medicines for Autoimmune Disorders: Rheumatoid Arthritis and Autoimmune Diabetes Mellitus

• Introduction
• Possible Mechanisms Underlying the Pathogenesis of Autoimmune Diseases
• Kampo Medicines for Autoimmune Diseases

Chapter 13. Kampo Medicine for Renal Inflammatory Conditions

• Introduction
• Characteristics of Japanese Kampo Medicine
• Inflammatory Pathways in Renal Diseases
• Kampo Medicine in Chronic Kidney Disease
• Kampo Medicine in Urinary Stone Disease
• Randomized Clinical Trials of Traditional Medicines in Kidney Disease
• Summary and Outlook

Chapter 14. Kampo Medicines for Infectious Diseases

• Introduction
• Influenza Virus Infection
• Hepatitis C Virus Infection
• Human Immunodeficiency Virus Infection
• Hepatitis B Virus Infection
• Herpes Simplex Virus Type 1 Infection
• Severe Acute Respiratory Syndrome Coronavirus Infection
• BK Virus–Associated Hemorrhagic Cystitis
• Human Papillomavirus Vaccine Adjuvant
• Candida albicans Infection
• Listeria monocytogenes Infection
• Propionibacterium acnes Infection
• Helicobacter pylori Infection
• Vibrio cholerae Infection
• Porphyromonas gingivalis and Other Oral Microorganism Infections
• Streptococcus pyogenes Infection

Chapter 15. Drug Delivery Aspects of Herbal Medicines

• Introduction
• Traditional Drug Delivery Systems
• Decoctions
• Infusions
• Extracts
• Pills
• Tinctures
• Powders
• Novel Drug Delivery Systems
• Liposomes
• Phytosomes
• Transferosomes
• Ethosomes
• Transdermal Drug Delivery Systems
• Nanoparticles
• Nanoemulsions
• Solid Lipid Nanoparticles
• Microspheres

Chapter 16. Regulatory Aspects of Herbal Medicine

• Introduction
• Need for Regulation of Herbal Medicine
• Regulatory Aspects of Herbal Medicine
• Assessment of Safety and Efficacy
• Safety Monitoring of Herbal Medicines
• Pharmacovigilance of Herbal Medicinal Products
• Current Scenario of Regulation
• Conclusion