Isotope Dilution Analysis
International Series of Monographs in Analytical Chemistry
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International Series of Monographs in Analytical Chemistry, Volume 49: Isotope Dilution Analysis focuses on the method of isotope dilution analysis (IDA). The book first discusses the principles, types, and theory of IDA. Classification of the methods of IDA; precision, accuracy, and sensitivity of IDA; and types of IDA are described. The text also examines experimental techniques, separation, and mass determination. The separation of components, reagents and tracers, and amount of substance separated are underscored. The text takes a look at the inorganic applications of IDA, including determination of elements and selected procedures. The text examines the applications of IDA in organic chemistry and biochemistry, particularly in the analysis of alcohols and ethers, steroids, penicillin, proteins and amino acids, and insecticides. The book discusses IDA with stable isotopes. Methods for the determination of isotopic composition, fundamentals and technique, and practical applications are underscored. The text also emphasizes the special applications of isotope dilution. Determination of the content of isotopic carriers in radioactive preparations; determination of the coefficient of self-absorption and specific activity; and determination of radioactive contaminants are discussed. The text is a vital reference for readers interested in isotope dilution analysis.
Table of Contents
Contents
Preface
1. Principles, Types and Theory of Isotope Dilution Analysis
1.1. General Principles
1.2. Classification of the Methods of IDA
1.3. Types of IDA
1.3.1. Direct IDA
1.3.2. Reverse IDA
1.3.3. Derivative IDA
1.3.4. The Substoichiometric Principle in IDA
1.3.5. Double IDA
1.3.6. Other Types of IDA
1.4. Precision, Accuracy and Sensitivity of IDA
1.4.1. Precision
1.4.2. Accuracy
1.4.3. Sensitivity
1.5. Advantages, Drawbacks, Trends
1.6. References
2. Experimental Techniques, Separation and Mass Determination
2.1. Reagents and Tracers
2.2. Separation of Components
2.2.1. Separation by Precipitation
2.2.2. Separation by Ion Exchange
2.2.3. Separation by Paper Chromatography and by The Ring-Oven Technique
2.2.4. Separation by Solvent Extraction
2.2.5. Electrochemical Separation
2.2.6. Separation by Distllation
2.2.7. Separation by Adsorption
2.3. Determination of the Amount of Substance Separate
2.3.1. Gravimetry
2.3.2. Titrimetry
2.3.3. Colorimetry
2.3.4. Flame Photometry
2.3.5. Fluorometry
2.3.6. Radiometry
2.4. References
3. Inorganic Applications
3.1. Determination of Various Elements
3.2. Selected Procedures
3.2.1. Determination of 137Cs in Mixtures of Fission Products
3.2.2. Determination of Sulphate
3.2.3. Determination of Carbonate
3.2.4. Determination of Cobalt in Steels and Non-Ferrous Alloys
3.2.5. Determination of Strontium and Calcium in Mixtures
3.3. References
4. Applications in Organic Chemistry and Biochemistry
4.1. Alcohols and Ethers 127
4.2. Carboxylic Acids, Acid Chlorides and Anhydrides
4.3. Sulpho Derivatives
4.4. Proteins and Amino Acids
4.5. Steroids
4.6. Vitamin B12
4.7. Penicillin
4.8. Insecticides
4.9. Other Applications in Organic Chemistry and Biochemistry
4.10. References
5. Isotope Dilution Analysis with Stable Isotopes
5.1. Introduction
5.2. Methods for the Determination of Isotopic Composition. Analysis by Mass Spectrometry
5.3. Fundamentals and Technique
5.4. Practical Applications
5.4.1. Applications in Organic Chemistry
5.4.2. Applications in Inorganic Chemistry
5.4.3. Determination of Geological Age
5.5. References
6. Special Applications of Isotope Dilution
6.1. Volume Determination
6.1.1. Determination of Water in The Human Body
6.1.2. Determination of the Volume of the Extracellular Fluid
6.1.3. Determination of the Volume of Erythrocytes, Plasma and Blood
6.2. Determination of Solubility
6.3. Determination of Radioactive Contaminants
6.4. Determination of the Content of Isotopic Carriers in Radioactive Preparations
6.5. Determination of Dissociation Constants
6.6. Studies On Reaction Rates and Equilibria
6.7. Determination of the Capacity of Ion Exchangers
6.8. Determination of the Coefficient of Self-Absorption and of Specific Activity
6.9. Measurement of Flow Rates
6.10. References
Index
Product details
- No. of pages: 194
- Language: English
- Copyright: © Pergamon 1972
- Published: January 1, 1972
- Imprint: Pergamon
- eBook ISBN: 9781483160924
About the Authors
J. Tölgyessy
T. Braun
Affiliations and Expertise
Institute of Inorganic and Analytical Chemistry
L. Eotvos University
Budapeat, Hungary