Functional Neural Transplantation IV - 1st Edition - ISBN: 9780128138793

Functional Neural Transplantation IV, Volume 231

1st Edition

Translation to Clinical Application, Part B

Serial Volume Editors: Stephen B. Dunnett Anders Björklund
Hardcover ISBN: 9780128138793
Imprint: Academic Press
Published Date: 26th May 2017
Page Count: 316
Tax/VAT will be calculated at check-out Price includes VAT (GST)

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Table of Contents

  1. Stem Cell Transplantation for Spinal Cord Injury Repair
       Paul Lu
    2. Plasticity and Regeneration in the Injured Spinal Cord After Cell Transplantation Therapy
       Satoshi Nori, Masaya Nakamura and Hideyuki Okano
    3. Transplantation of GABAergic Interneurons for Cell-Based Therapy
       Julien Spatazza, Walter R. Mancia Leon and Arturo Alvarez-Buylla
    4. Rebuilding CNS Inhibitory Circuits to Control Chronic Neuropathic Pain and Itch
       Joao M. Braz, Alex Etlin, Dina Juarez-Salinas, Ida J. Llewellyn-Smith and Allan I. Basbaum
    5. From Transplanting Schwann Cells in Experimental Rat Spinal Cord Injury to their Transplantation into Human Injured Spinal Cord in Clinical Trials
       Mary B. Bunge, Paula V. Monje, Aisha Khan and Patrick M. Wood
    6. Recruitment of Endogenous CNS Stem Cells for Regeneration in Demyelinating Disease
       Natalia A. Murphy and Robin J.M. Franklin
    7. Progenitor Cell-Based Treatment of Glial Disease
       Steven A. Goldman
    8. Pluripotent Stem Cells and their Utility in Treating Photoreceptor Degenerations
       Nozie D. Aghaizu, Kamil Kruczek, Anai Gonzalez-Cordero, Robin R. Ali and Rachael A. Pearson
    9. Stem Cell-Derived Retinal Pigment Epithelium Transplantation for Treatment of Retinal Disease
       Britta Nommiste, Kate Fynes, Victoria E. Tovell, Conor Ramsden, Lyndon da Cruz and Peter Coffey
    10. Transplantation of Reprogrammed Neurons  for Improved Recovery After Stroke
       Zaal Kokaia, Daniel Tornero and Olle Lindvall

Description

Functional Neural Transplantation IV: Translation to Clinical Application, Part B, Volume 231 provides the current status of cell transplantation in the nervous system, focusing on the conditions for achieving structural repair and functional recovery. New to this edition are chapters on Plasticity and Regeneration in the Injured Spinal Cord After Cell Transplantation Therapy, Transplantation of GABAergic Interneurons for Cell-Based Therapy, Rebuilding CNS Inhibitory Circuits to Control Chronic Neuropathic Pain and Itch, From Transplanting Schwann Cells in Experimental Rat Spinal Cord Injury to their Transplantation into Human Injured Spinal Cord in Clinical Trials, and the Recruitment of Endogenous CNS Stem Cells for Regeneration in Demyelinating Disease.

As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments in cellular and molecular science, providing the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, while also addressing the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair.

Key Features

  • Provides a comprehensive set of critical reviews covering the field
  • Presents state-of-the-art topics in science and translational medicine
  • Written by international leaders in the field of neural transplantation

Readership

Experimental and clinical neuroscientists in the field of neurodegenerative disease, plasticity and advanced cellular therapeutics, seeking state of the art critical reviews on the current status and future prospects of cell-based therapy in neuroregenerative medicine. The critical reviews are written by the leaders in their specialization areas, and are likely to be of value and interest to post-graduate research students, advanced medical trainees, post-doctoral scientists and established faculty who are moving into or already engaged in the field


Details

No. of pages:
316
Copyright:
© Academic Press 2017
Published:
Imprint:
Academic Press
Hardcover ISBN:
9780128138793

About the Serial Volume Editors

Stephen B. Dunnett Serial Volume Editor

Dunnett is a behavioural neuroscientist who started a lifelong collaboration with the Björklund team in 1979 to explore the functional consequences of cell transplantation method in animal models of neurodegenerative disease, in particular involving cell replacement and repair of the basal ganglia. He has developed models and novel methods of motor and cognitive assessment to apply behavioural analysis not simply to assess functional efficacy of implanted cells, but as a tool to study the mechanisms of cell integration, circuit reconstruction and functional repair. In parallel his laboratory originated the first UK trial of cell transplantation in Huntington’s disease, and provides the source of clinical grade cells for further ongoing trials in Parkinson’s disease.

Affiliations and Expertise

Cardiff University, Cardiff, UK

Anders Björklund Serial Volume Editor

As a neuroanatomist and developmental neurobiologist, during the 1970s Björklund’s lab originated reliable methods for transplantation of embryonic tissues into brain that pioneered practical cell transplantation in the central nervous system, providing the basis for technologies that are now used by laboratories world-wide. In parallel, work in the field has progressed from basic anatomical and developmental studies in experimental animals, via applications for assessing cell replacement and repair using primary and stem cells in the damaged brain, and now underpinning the majority of methods in development for cell therapy in patients. His laboratory continues to analyse the fundamental neurobiology and principles of cell transplantation, regeneration and integration in the CNS, as well as originating the first trials of effective clinical cell transplantation (for Parkinson’s disease) in patients.

Affiliations and Expertise

Lund University, Lund, Sweden