Noradrenergic Signaling and Astroglia - 1st Edition - ISBN: 9780128050880, 9780128134269

Noradrenergic Signaling and Astroglia

1st Edition

eBook ISBN: 9780128134269
Hardcover ISBN: 9780128050880
Imprint: Academic Press
Published Date: 20th July 2017
Page Count: 342
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Noradrenergic Signaling and Astroglia integrates what is known about the active role of astroglia in the locus coeruleus-noradrenergic system and outlines the most recent advances in the field. It discusses the molecular mechanisms underlying norepinephrine-induced receptor activation in astroglia, cellular metabolism and CNS energy provision, in vitro, ex vivo, and in vivo models, gliosignalling and neuronal activity, and astroglial networks, gap junctions, and morphological plasticity. The book also addresses the role of astroglial adrenergic receptor activation in memory formation, cognition, regulation of sleep homeostasis, and lastly in neurological disorders, including trauma (cellular edema), neurodegeneration (Alzheimer’s disease), and neuroinflammation (multiple sclerosis). Noradrenergic Signaling and Astroglia is a valuable source of new knowledge for a wide audience, including graduate students, post-doctoral fellows, and researchers in neuroscience, life sciences, and the biological and biomedical sciences.

Key Features

  • Covers what is currently known about the role of astroglia in the noradrenergic system
  • Provides biochemical and physiological mechanistic data to understand how noradrenergic signals acting on astroglia produce observed effects
  • Includes figures and tables of structures, mechanisms and processes related to astroglia and noradrenergic signaling in CNS


Neuroscientists, graduate and undergraduate students in biological and biomedical sciences, post-doctoral fellows, researchers

Table of Contents

  1. Locus coeruleus noradrenergic neurons and astroglia in health and disease
      Robert Zorec, Nina Vardjan and Alexei Verkhratsky
    2. Astroglial adrenergic receptor signaling in brain cortex
      Leif Hertz and Ye Chen
    3. White matter astrocytes: Adrenergic mechanisms
      Maria Papanikolaou and A.M. Butt
    4. Role for astroglial α1-adrenergic receptors in glia-neuron communications and aging-related metaplasticity in the neocortex
      Ulyana Lalo and Yuriy Pankratov
    5. Adrenergic Ca2+ and cAMP excitability: Effects on glucose availability and cell morphology in astrocytes
      Nina Vardjan, Marko Kreft and Robert Zorec
    6. Adrenergic receptors on astrocytes modulate gap junctions
      Eliana Scemes, Randy F. Stout, Jr. and David C. Spray
    7. Fluxes of lactate into, from, and among gap junction-coupled astroglia and their interaction with noradrenaline
      Gerald A. Dienel
    8. Dialogue between astrocytes and noradrenergic neurones via L-lactate
      Anja G. Teschemacher and Sergey Kasparov
    9. Noradrenergic system and memory: The role of astrocytes
      Manuel Zenger, Sophie Burlet-Godinot, Jean-Marie Petit and Pierre J. Magistretti
    10. Hippocampal noradrenaline regulates spatial working memory in the rat
      Rosario Gulino, Anna Kostenko, Gioacchino De Leo, Serena Alexa Emmi, Domenico Nunziata and Giampiero Leanza
    11. Enteric astroglia and noradrenergic/purinergic signaling
      Vladimir Grubišić and Vladimir Parpura
    12. Noradrenaline drives structural changes in astrocytes and brain extracellular space
      Ang D. Sherpa, Chiye Aoki and Sabina Hrabetova
    13. Signalling pathway of ß-adrenergic receptor in astrocytes and its relevance to brain oedema
      Alexei Verkhratsky and Liang Peng
    14. Noradrenaline, astroglia, and neuroinflammation
      José L.M. Madrigal
    15. Astrocytic ß2 adrenergic receptors and multiple sclerosis
      Jacques De Keyser
    16. Potentiation of ß-amyloid–induced cortical inflammation by noradrenaline and noradrenergic depletion: Implications for Alzheimer’s disease
      Douglas L. Feinstein and Michael T. Heneka


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© Academic Press 2017
Academic Press
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