Section 1 Basic Science
1. Genetics of Huntington disease
2. Mechanisms underlying neurodegeneration in Huntington disease: Applications to novel disease-modifying therapies
Section 2 Clinical Aspects
3. Epidemiology of Huntington disease
4. Statistical modelling of Huntington disease onset
5. The diagnosis and natural history of Huntington’s disease
6. Preclinical cognitive and behavioral changes in Huntington disease
7. Preclinical motor manifestations of Huntington disease
8. The highly anxious individual presenting for Huntington disease predictive genetic testing: the psychiatrist’s role in assessment and counseling
9. Reproductive options for Huntington disease families
10. Genetic testing for Huntington disease
Section 3 Treatment of Huntington Disease
11. Medical treatment of behavioral manifestations of Huntington disease
12. Medical management of motor manifestations of Huntington disease
13. The role of rehabilitation therapy in Huntington disease
14. Contemporary health care for Huntington disease
15. The impact of Huntington disease on young people
16. Making a measurable difference in advanced Huntington disease care
Section 4 Experimental Therapeutics
17. New symptomatic therapies for Huntington disease
18. Motor outcome measures in Huntington disease clinical trials
19. Cognitive outcome measures in Huntington disease clinical drug trials
Section 5 Biomarkers
20. Structural imaging in premanifest and manifest Huntington disease
21. Functional imaging in Huntington disease
Huntington Disease summarizes the most recent findings related to the disease, providing both cutting edge coverage for clinical/research specialists looking to expand their knowledge base of Huntington disease information, as well as solid groundwork for advanced students from various backgrounds (neurology, psychiatry, neuropsychology, genetics). The volume includes all major areas of Huntington disease clinical care and research, whereas many other HD texts focus solely on neurological symptoms.
This book also addresses behavioral and cognitive symptoms, brain imaging, and family dynamics and therapeutic alliances in working with individuals affected by HD. Clinical trials are covered extensively, including design considerations for therapeutic studies. The devastating nature of Huntington’s disease is well appreciated throughout the neuroscience, neurology, and psychiatric communities, and a great amount of basic and clinical research is currently taking place. However, much of that occurs in isolated research silos, and it is critical that an interdisciplinary resource be developed to provide in depth information to enhance communication and collaboration. This volume in the Handbook of Clinical Neurology series is that resource.
- Includes coverage of both basic science and clinical aspects of the disease, as well as treatment, experimental therapeutics, and biomarkers
- Provides an essential resource for the non-neurologist, including necessary background for understanding the disease before making a more detailed study proposal
- Provides an interdisciplinary approach that can be applied in everyday clinic and research efforts
- Features chapters edited by leaders in the field around the globe—the broadest expert coverage available
Researchers, clinicians and advanced students in the fields of neurology, psychiatry, neuropsychology, genetics and clinical neuroscience
- No. of pages:
- © Elsevier 2017
- 24th October 2017
- Hardcover ISBN:
- Hardcover ISBN:
- eBook ISBN:
Dr. Feigin is a Professor of Neurology and Molecular Medicine at the Hofstra Northwell School of Medicine. He directs the Huntington’s Disease Center at North Shore University Hospital and the Laboratory of Experimental Therapeutics for Movement Disorders at The Feinstein Institute for Medical Research of the Northwell Health System in Manhasset, NY. Dr. Feigin has been involved in Huntington’s disease (HD) clinical research for more than 20 years; he participated in the Venezuela HD project for 10 years beginning in 1993. He has been a site principal investigator on more than 30 National Institute of Health and industry sponsored clinical trials of new treatments for HD and Parkinson’s disease (PD), and he has been a principal investigator on several multicenter clinical trials for HD and PD. His independent research focuses on using state-of-the-art imaging methods to elucidate the mechanisms underlying current therapies for movement disorders. This work has led to the use of imaging as a biomarker in clinical trials of novel therapies for HD and PD. In addition, Dr. Feigin is interested in utilizing imaging as a biomarker for HD in the premanifest phase of illness. Dr. Feigin has served in many leadership roles for national and international academic consortiums studying HD including the Huntington Study Group. In addition, he remains a committed and busy clinician caring for patients and families with HD and other Movement Disorders.
Laboratory of Experimental Therapeutics for Movement Disorders, The Feinstein Institute for Medical Research, Manhasset, NY, USA
Karen E. Anderson, MD is Director of the Huntington Disease Care, Education and Research Center (HDCERC), a joint endeavor of Georgetown University Medical Center (GUMC) and MedStar Georgetown University Hospital.Dr. Anderson is a neuropsychiatrist with dual appointments in the departments of psychiatry and neurology; she leads a team of neurologists, psychiatrists, neuropsychologists, genetic counselors, social workers and other specialists who make up the Huntington Disease Center.
Dr. Anderson's work combines her lifelong interest in behavior with an interest in understanding how disease can affect the brain and cause behavioral symptoms. In addition to seeing patients and their families, Dr. Anderson is active in research. She is currently the co-principal investigator on a clinical trial studying a medication to treat Huntington's disease, and another studying a medication for tardive dyskinesia, a neurological disorder. Dr. Anderson is also involved in research to develop treatment for the behavioral symptoms of Parkinson's disease, brain injury and Alzheimer's disease.
Dr. Anderson is on the executive committee of the Huntington Study Group, a collaborative organization of physicians and healthcare providers from around the world dedicated to clinical research of Huntington's disease. She's also an affiliate member of the European Huntington's Disease Network. In 2013, the Baltimore Huntington Disease Society of America affiliate awarded her their Celebration of Hope Award for excellence in Huntington's disease clinical care.
MedStar Health, Georgetown University Hospital and Georgetown University Medical Center, Huntington Disease Care, Education and Research Center, Department of Psychiatry, Washington, DC, USA