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iPSCs for Modeling Central Nervous System Disorders, Volume 6 - 1st Edition - ISBN: 9780323857642, 9780323856423

iPSCs for Modeling Central Nervous System Disorders, Volume 6

1st Edition

Editor: Alexander Birbrair
eBook ISBN: 9780323856423
Paperback ISBN: 9780323857642
Imprint: Academic Press
Published Date: 28th April 2021
Page Count: 352
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Table of Contents

1. In vitro human stem cell mediated CNS Platforms: progress and challenges
Michael Coleman, PhD, President and CEO, Theratome Bio, Indianapolis, IN, USA
2. iPSCs for Modeling of X-linked dystonia-parkinsonism
Christine Klein, PhD, Professor, Institute of Neurogenetics, University of Luebeck, Lübeck, Germany
3. iPSCs for Modeling of Leber’s hereditary optic neuropathy
Shih-Hwa Chiou, MD, PhD, Professor, National Yang-Ming University, Taipei, Taiwan
4. iPSC-based modeling in psychiatric disorders: Opportunities and Challenges
Dietmar Spengler, PhD, Project Group Leader, Max Planck Institute of Psychiatry, München, Germany
5. iPSCs for Modeling of hereditary spastic paraplegia
Xuejun Li, PhD, Associate Professor, Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL, USA
6. iPSCs for Modeling of Autism
Thomas Martin Durcan, PhD, Assistant Professor, Department of Neurology and Neurosurgery, The Neuro, Montreal, Canada
7. iPSCs for Modeling of Spinal Muscular Atrophy
Allison Ebert, PhD, Associate Professor, Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
8. iPSCs for Modeling of Alzheimer’s Disease
Yanhong Shi, PhD, Professor, Department of Developmental and Stem Cell Biology, City of Hope, Duarte, CA, USA
9. iPSCs for Modeling of ALS
Rivka Ofir, PhD, Senior Researcher, Faculty of Health Sciences, Ben-Gurion University of the Negev, Be’er Sheva. Israel
10. Studying Non-Cell-Autonomous Neurodegeneration in Parkinson’s Disease with iPSCs
Jari Koistinaho, MD, PhD, Professor, Stem Cell Research, University of Eastern Finland, Kuopio, Finland
11. iPSCs for modeling Angelman syndrome
Simao Jose Teixeira da Rocha, PhD, Staff Scientist, Institute of Molecular Medicine, Lisbon, Portugal
12. In Vivo Phenotyping of Familial Parkinson’s Disease with iPSCs
Rebecca Matsas, PhD, Research Director, Head of Department of Neurobiology, Hellenic Pasteur Institute, Athens, Greece
13. iPSCs for Modeling Schizophrenia
Sangmi Chung, PhD, Associate Professor of Cell Biology & Anatomy, New York Medical College, Valhalla, New York, USA
14. iPSCs for Modeling Neurodevelopmental Disorders
Zhexing Wen, PhD, Assistant Professor, Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
15. iPSCs for Modeling of Multiple Sclerosis
Jaime Imitola, MD, PhD, Associate Professor of Neurology, Genetics and Genome Sciences, UConn Health, Farmington, CT, USA
16. Modeling developmental changes in HD using iPSCs
Lisa Ellerby, PhD, Professor, Buck Institute for Research on Aging, Novato, CA, USA


The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology.

iPSCs for Modeling Central Nervous System Disorders, Volume 6 addresses how induced pluripotent stem cells can be used to model various CNS disorders.

Somatic cells can be reprogrammed into Induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several CNS diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different CNS pathologies. Further insights into these mechanisms will have important implications for our understanding of CNS disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several CNS disorders. This volume will cover what we know so far about the use of iPSCs to model different CNS disorders, such as: Alzheimer’s disease, Autism, Amyotrophic Lateral Sclerosis, Schizophrenia, Fragile X Syndrome, Spinal Muscular Atrophy, Rett Syndrome, Angelman syndrome, Parkinson`s Disease, Leber Hereditary Optic Neuropathy, Anorexia Nervosa, and more.

The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and neuroscience; and is contributed by world-renowned authors in the field.

Key Features

    • Provides overview of the fast-moving field of induced pluripotent stem cell technology and its application in neurobiology.
    • Covers the following CNS diseases: Alzheimer’s disease, Autism, Amyotrophic Lateral Sclerosis, Schizophrenia, Fragile X Syndrome, Spinal Muscular Atrophy, Rett Syndrome, Angelman syndrome, Parkinson`s Disease, Leber Hereditary Optic Neuropathy, Anorexia Nervosa, and more.
    • Contains description of cutting-edge research on the development of disease-specific human pluripotent stem cells. These cells allow us to study cellular and molecular processes involved in several CNS human diseases.


Researchers and scientists in stem cell therapy, cell biology, regenerative medicine, and organ transplantation. Graduate and undergraduate students in the above fields


No. of pages:
© Academic Press 2021
28th April 2021
Academic Press
eBook ISBN:
Paperback ISBN:

Ratings and Reviews

About the Editor

Alexander Birbrair

Dr. Alexander Birbrair received his bachelor’s biomedical degree from Santa Cruz State University in Brazil. He completed his PhD in Neuroscience, in the field of stem cell biology, at the Wake Forest School of Medicine under the mentorship of Osvaldo Delbono. Then, he joined as a postdoc in stem cell biology at Paul Frenette’s laboratory at Albert Einstein School of Medicine in New York. In 2016, he was appointed faculty at Federal University of Minas Gerais in Brazil, where he started his own lab. His laboratory is interested in understanding how the cellular components of different tissues function and control disease progression. His group explores the roles of specific cell populations in the tissue microenvironment by using state-of-the-art techniques. His research is funded by the Serrapilheira Institute, CNPq, CAPES, and FAPEMIG. In 2018, Alexander was elected affiliate member of the Brazilian Academy of Sciences (ABC), and, in 2019, he was elected member of the Global Young Academy (GYA). He is the Founding Editor and Editor-in-Chief of Current Tissue Microenvironment Reports, and Associate Editor of Molecular Biotechnology. Alexander also serves in the editorial board of several other international journals: Stem Cell Reviews and Reports, Stem Cell Research, Stem Cells and Development, and Histology and Histopathology.

Affiliations and Expertise

Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil Department of Radiology, Columbia University Medical Center, Medical Center, USA