Ions, Cell Proliferation, and Cancer

Ions, Cell Proliferation, and Cancer

1st Edition - January 1, 1982

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  • Editors: Alton L. Boynton, Wallace L. McKeehan, James F. Whitfield
  • eBook ISBN: 9781483277486

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Ions, Cell Proliferation, and Cancer present the credibility of ions as specific regulators of cell proliferation. This book provides an understanding of the control of cell proliferation and the deregulated proliferation of cancer cells. Organized into three sections encompassing 32 chapters, this book begins with an overview of the important role that ions in animal cells play in a variety of fundamental processes associated with essential cell functions. This text then examines the relationship between ionic events and cellular production, specifically in mammalian cell systems. Other chapters consider the development of atomic absorption spectrophotometry as a method for measuring inorganic cations. This book discusses as well the two widely applicable methods for measuring free concentrations of ions inside cells. The final chapter deals with magnesium ion as the most abundant divalent action in living cells. This book is a valuable resource for animal cell biologists, molecular biologists, and research workers.

Table of Contents

  • Contributors


    Section I: Methodology

    Direct Observation of the State of 23Na+ Ions in Intact Cells and Tissues by Noninvasive NMR Spectroscopy: Intracellular Na+ Ions in Human Normal and Leukemic Lymphocytes

    Energy Dispersive Spectroscopy in the Study of the Ionic Regulation of Growth in Normal and Tumor Cells

    Atomic Absorption Measurement of Cations in Cultured Cells

    Ion-Selective Microelectrodes and Fluorescent Probes for Measurement of Intracellular Ion Activities

    Intracellular Calcium Measurements Using NMR Spectroscopy of Fluorine-Labelled Chelators

    Techniques for the Measurement of Calcium Distribution, Calcium Fluxes, and Cytosolic-Free Calcium in Mammalian Cells

    Section II: Monovalent Ions, Cell Proliferation, and Cancer

    Monovalent Cations, Cell Proliferation, and Cancer: An Overview

    Monovalent Cations and the Control of Hepatocyte Proliferation in Chemically Defined Medium

    The Potassium-Sensitivity-Shift and Other Matters

    Na+/H+ Exchange in the Action of Growth Factors

    Hormonal Regulation of Na+-Dependent Transport in Hepatocytes and Hepatoma Cells

    Intracellular Potassium Activity During Liver Regeneration

    Transepithelial Ion Transport and Differentiation in Epithelial Cell Cultures

    Na+, K+, H+, and Protein Phosphorylation in the Growth Factor-Induced G0/G1 Transition in Fibroblasts

    Relation between K+, Na+, Ca2+, and Proliferation of Normal and Transformed 3T3 Mouse Cells

    The Involvement of Ca+2 in the Serum Stimulation of Na+ Influx in Human Fibroblasts

    Monovalent Ion Fluxes, Cyclic Nucleotides, and the Stimulation of DNA Synthesis in Quiescent Cells

    Section III: Divalent Ions, Cell Proliferation, and Cancer

    The Roles of Calcium and Magnesium in Cell Proliferation: An Overview

    Eggs Are Activated by a Calcium Explosion; Carcinogenesis May Involve Calcium Adaptation and Habituation

    Ionic Logic in Activation of the Cell Cycle

    The Cascade of Events Initiated by Rises in Cytosolic Ca+2 and pH Following Fertilization in Sea Urchin Eggs

    Calcium, Phosphate, and Cell Proliferation

    The Stimulation of Neonatal Rat Hepatocyte DNA Synthesis and Division by Epidermal Growth Factor (EGF), Glucagon, and Insulin Is Calcium-Dependent

    Phospholipase and Prostaglandin Synthesis in the Stimulation of Cell Proliferation by Platelet-Derived Growth Factor: The Role of Calcium

    Calcium and Lymphocyte Activation

    Mediation by Calcicalmodulin and Cyclic AMP of Tumor Promoter-Induced DNA Synthesis in Calcium-Deprived Rat Liver Cells

    Cyclic AMP and Ornithine Decarboxylase in Cell Proliferation

    Calmodulin Is an Important Regulatory Molecule in Cell Proliferation

    Calmodulin and Calmodulin-Binding Proteins in Normal and Virus-Transformed Fibroblasts: Levels, Subcellular Distribution, and Regulation

    Calcium-Binding Proteins and Cell Proliferation

    Extracellular Calcium Regulates Growth and Terminal Differentiation of Cultured Mouse Epidermal Cells

    The Role of Magnesium in Cell Proliferation and Transformation


Product details

  • No. of pages: 566
  • Language: English
  • Copyright: © Academic Press 1982
  • Published: January 1, 1982
  • Imprint: Academic Press
  • eBook ISBN: 9781483277486

About the Editors

Alton L. Boynton

Wallace L. McKeehan

James F. Whitfield

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