Ionic Liquids in Lipid Processing and Analysis

Ionic Liquids in Lipid Processing and Analysis

Opportunities and Challenges

1st Edition - February 11, 2016

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  • Editors: Xuebing Xu, Zheng Guo, Ling-Zhi Cheong
  • Hardcover ISBN: 9781630670474
  • eBook ISBN: 9781630670481

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This book serves as a reference for those interested in state-of-the-art research on the science and technology of ionic liquids (ILs), particularly in relation to lipids processing and analysis. Topics include a review of the chemistry and physics of ILs as well as a quantitative understanding of structure-activity relationships at the molecular level. Further, chapter authors examine the molecular basis of the toxicity of ILs, the prediction of the properties of ILs, and the rationale and steps toward a priori design of ionic liquids for task-defined applications. Emerging research in developing lipid-inspired ILs and their prospective use in drug formulation is described. Among the highlights are the latest advances in IL-mediated biocatalysis and biotransformation, along with lipase production, purification, and activation.

Key Features

  • Reviews the state-of-the-art applications of ionic liquids in lipid processing and relevant areas from a variety of perspectives
  • Summarizes the latest advances in the measurement of the physical and chemical properties of ionic liquids and available databases of thermodynamic property datapoints
  • Presents the tremendous opportunities provided and challenges faced from ionic liquids as a newly emerging technology for lipids processing area


researchers in biotechnology, biocatalysis, industrial oil products, and green solvent use, chemists, chemical engineers

Table of Contents

    • List of Contributors
    • Preface
    • Chapter 1. Are Ionic Liquids Ready for Lipids Processing?: An Introduction to the Book
      • 1.1. Ionic Liquids, Not Just a Neoteric Solvent: Expanding in Diverse Fields
      • 1.2. Evolution of Ionic Liquid Concept
      • 1.3. Opportunities Offered by Ionic Liquids for Lipid Processing
      • 1.4. What Is New in This Book?
    • Chapter 2. Biocatalysis and Biotransformation in Ionic Liquids
      • 2.1. Introduction to Ionic Liquids for Biocatalysis: Aim and Scope
      • 2.2. Ionic Liquids and Oxidoreductases
      • 2.3. Ionic Liquids and Other Classes of Enzymes
      • 2.4. Deep Eutectic Solvents in Biocatalysis
      • 2.5. Conclusions and Outlook
    • Chapter 3. Lipase Production and Purification from Fermentation Broth Using Ionic Liquids
      • 3.1. Introduction
      • 3.2. Common Methods of Lipase Extraction
      • 3.3. Lipase Extraction by IL-Based ABS
      • 3.4. Main Conclusions
      • 3.5. Critical Analysis and Future Challenges
    • Chapter 4. Lipase Activation and Stability Enhancement in Ionic Liquids
      • 4.1. Introduction
      • 4.2. Effect of Physical Properties of ILs on Lipase Activity and Stability
      • 4.3. Methods to Improve Lipase Activity and Stability
      • 4.4. Deep Eutectic Solvents for Lipase Activation
      • 4.5. Prospects
    • Chapter 5. Rational Design of Ionic Liquids for Lipid Processing
      • 5.1. Introduction
      • 5.2. Experimental Approaches for Characterization of Physicochemical Properties of ILs
      • 5.3. Predictions of Physicochemical Properties of ILs
      • 5.4. Rational Design of ILs for Lipids Processing
      • 5.5. Concluding Remarks and Perspectives
    • Chapter 6. Synthesis and Properties of Lipid-Inspired Ionic Liquids
      • 6.1. Introduction
      • 6.2. Lipid-Inspired Ionic Liquids: A New Class of Lipidoid Materials
      • 6.3. Conclusion and Prospective
    • Chapter 7. New Opportunities from Ionic Liquid for Chemical and Biochemical Processes of Lipids
      • 7.1. Introduction
      • 7.2. Ionic Liquids for Drug Delivery Purposes
      • 7.3. Formulations of Active Pharmaceutical Ingredients with Ionic Liquids for Drug Delivery
      • 7.4. Summary and Conclusions
    • Chapter 8. Ionic Liquids in Acylglycerol Synthesis and Modification
      • 8.1. Introduction
      • 8.2. Enzymatic Production of Monoacylglycerols Assisted by Ionic Liquids
      • 8.3. Enzymatic Production of Diacylglycerols Assisted by Ionic Liquids
      • 8.4. Future Perspectives
    • Chapter 9. Ionic Liquids in Lipid Extraction and Recovery
      • 9.1. Introduction
      • 9.2. The Extraction Process
      • 9.3. The Extraction Unit Operation
      • 9.4. The Recovery Unit Operation
      • 9.5. Molecular Modeling and Simulation
      • 9.6. Future Trends
    • Chapter 10. Ionic Liquids in the Synthesis of Antioxidant Targeted Compounds
      • 10.1. Introduction
      • 10.2. Extraction of Natural Antioxidants with Ionic Liquids
      • 10.3. Incentives of Antioxidants Modification
      • 10.4. Modification of Antioxidants in Ionic Liquids
      • 10.5. Antioxidant Synthesis in Ionic Liquids
      • 10.6. Summary and Future Perspectives
    • Chapter 11. Ionic Liquids in the Synthesis of Sugar/Carbohydrate and Lipid Conjugates
      • 11.1. Introduction
      • 11.2. Potential Carbohydrate Fatty Acid Esters: Availability and Properties
      • 11.3. Production Strategy of Carbohydrate Fatty Acid Esters
      • 11.4. Role of Ionic Liquids in Enzymatic Synthesis of Carbohydrate Fatty Acid Esters
      • 11.5. Role of Ionic Liquid in Chemical Synthesis of Carbohydrate Fatty Acid Esters
      • 11.6. Remarks and Future Aspects
    • Chapter 12. Ionic Liquids in the Production of Biodiesel and Other Oleochemicals
      • 12.1. Production of Biodiesel
      • 12.2. Preparation of Biolubricants
      • 12.3. Preparation of Polymers and Plasticizers
      • 12.4. Preparation of Other Oleochemicals
      • 12.5. Conclusion
    • Chapter 13. Toxicity of Ionic Liquids: Past, Present, and Future
      • 13.1. Past: Extensive Studies on Ionic Liquid Toxicity
      • 13.2. Present: Understanding the Molecular Basis of Ionic Liquid Toxicity
      • 13.3. Future: Moving Beyond Toxicity Toward New Potential Applications
    • Chapter 14. Ionic Liquids in Lipid Analysis
      • 14.1. Introduction
      • 14.2. Ionic Liquids in Gas Chromatography Analysis
      • 14.3. Ionic Liquids in Liquid Chromatography Analysis
      • 14.4. Ionic Liquids as MALDI Matrices
      • 14.5. Ionic Liquids in Capillary Electrophoresis Analysis Technique
      • 14.6. Application of Ionic Liquids in Enrichment of n-3 Polyunsaturated Fatty Acids/Esters
      • 14.7. Prospects
    • Index

Product details

  • No. of pages: 484
  • Language: English
  • Copyright: © Academic Press and AOCS Press 2016
  • Published: February 11, 2016
  • Imprint: Academic Press and AOCS Press
  • Hardcover ISBN: 9781630670474
  • eBook ISBN: 9781630670481

About the Editors

Xuebing Xu

Xuebing Xu, is the general manager for Wilmar Global R&D Center. He is also honorary professor in the Faculty of Science and Technology of Aarhus University, Denmark. His research interests include lipid technology, enzyme technology, food functionality, food nanotechnology, biofuel technology, etc. with particular focus on structured lipids, biocatalysis, process technology, phospholipids, ionic liquids, biodiesels, food physics, etc. Xuebing Xu is also associate editor for JAOCS, ad hoc reviewer for more than 150 papers and members of editorial board for journals including EJLST, Open Biotechnology, etc. He has authored more than 200 publications and over 30 book chapters in lipid-related researches.

Affiliations and Expertise

Wilmar Global Research and Development Center, Shanghai, China

Zheng Guo

Zheng Guo, Ph.D., obtained his Ph.D. degree in Biochemical Engineering at Tianjin Univeristy in 2004, China. Then he moved to Denmark as a Research Assistant Professor in Technical University of Denmark. In 2008, he was employed as a Research Associate Professor in Aarhus University. During 2011-2012, he was sponsored by Novartis as a visiting scholar in MIT for collaboration research. In 2012 he was promoted as Associate Professor (faculty).

As the principle researcher, Dr. Guo has lead and co-ordinated a few national and international projects from Danish Independent Research Fundation, Danish Advanced Technology Foundation etc. He devoted his effort to materialize the technology for industrial application and production of lipids. He acquired a few world and the US patents.

As an active researcher in lipids/biotechnology field, Dr. Guo has authorized over 80 peer-reviewed papers in international journals, over 60 conference proceedings, 6 book chapters, co-editors of 3 books.

His research involves Lipids biotechnology; Ionic liquid-mediated biotransformation; Lipase and micro-aqueous enzymology; Biorefinery and bioenergy; Lipid microbiology, Fermentation and downstream process; and Nanolipids.

Affiliations and Expertise

Department of Engineering, Aarhus University, Aarhus, Denmark

Ling-Zhi Cheong

Ling-Zhi Cheong, Ph.D. actively participates and engages in research projects with both academic and industrial researchers in the field of enzyme technology, biocatalysis and biotransformation, lipids and phospholipids processing, lipid physics and functionality, food colloids especially surface active compounds with antioxidative properties and encapsulation technology. To date, she has actively authored and co-authored peer-reviewed articles and book chapters in aforementioned research areas.

Affiliations and Expertise

Department of Food Science, School of Marine Science, Ningbo University, China

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