Ionic Liquids in Lipid Processing and Analysis

This book serves as a reference for those interested in state-of-the-art research on the science and technology of ionic liquids (ILs), particularly in relation to lipids processing and analysis. Topics include a review of the chemistry and physics of ILs as well as a quantitative understanding of structure-activity relationships at the molecular level. Further, chapter authors examine the molecular basis of the toxicity of ILs, the prediction of the properties of ILs, and the rationale and steps toward a priori design of ionic liquids for task-defined applications.

Emerging research in developing lipid-inspired ILs and their prospective use in drug formulation is described. Among the highlights are the latest advances in IL-mediated biocatalysis and biotransformation, along with lipase production, purification, and activation.

• Reviews the state-of-the-art applications of ionic liquids in lipid processing and relevant areas from a variety of perspectives
• Summarizes the latest advances in the measurement of the physical and chemical properties of ionic liquids and available databases of thermodynamic property datapoints
• Presents the tremendous opportunities provided and challenges faced from ionic liquids as a newly emerging technology for lipids processing area
  

researchers in biotechnology, biocatalysis, industrial oil products, and green solvent use, chemists, chemical engineers

• List of Contributors
• Preface
• Chapter 1. Are Ionic Liquids Ready for Lipids Processing?: An Introduction to the Book
  • 1.1. Ionic Liquids, Not Just a Neoteric Solvent: Expanding in Diverse Fields
  • 1.2. Evolution of Ionic Liquid Concept
  • 1.3. Opportunities Offered by Ionic Liquids for Lipid Processing
  • 1.4. What Is New in This Book?
• Chapter 2. Biocatalysis and Biotransformation in Ionic Liquids
  • 2.1. Introduction to Ionic Liquids for Biocatalysis: Aim and Scope
  • 2.2. Ionic Liquids and Oxidoreductases
  • 2.3. Ionic Liquids and Other Classes of Enzymes
  • 2.4. Deep Eutectic Solvents in Biocatalysis
  • 2.5. Conclusions and Outlook
• Chapter 3. Lipase Production and Purification from Fermentation Broth Using Ionic Liquids
  • 3.1. Introduction
  • 3.2. Common Methods of Lipase Extraction
  • 3.3. Lipase Extraction by IL-Based ABS
  • 3.4. Main Conclusions
  • 3.5. Critical Analysis and Future Challenges
• Chapter 4. Lipase Activation and Stability Enhancement in Ionic Liquids
  • 4.1. Introduction
  • 4.2. Effect of Physical Properties of ILs on Lipase Activity and Stability
  • 4.3. Methods to Improve Lipase Activity and Stability
  • 4.4. Deep Eutectic Solvents for Lipase Activation
  • 4.5. Prospects
• Chapter 5. Rational Design of Ionic Liquids for Lipid Processing
  • 5.1. Introduction
  • 5.2. Experimental Approaches for Characterization of Physicochemical Properties of ILs
  • 5.3. Predictions of Physicochemical Properties of ILs
  • 5.4. Rational Design of ILs for Lipids Processing
  • 5.5. Concluding Remarks and Perspectives
• Chapter 6. Synthesis and Properties of Lipid-Inspired Ionic Liquids
  • 6.1. Introduction
  • 6.2. Lipid-Inspired Ionic Liquids: A New Class of Lipidoid Materials
  • 6.3. Conclusion and Prospective
• Chapter 7. New Opportunities from Ionic Liquid for Chemical and Biochemical Processes of Lipids
  • 7.1. Introduction
  • 7.2. Ionic Liquids for Drug Delivery Purposes
  • 7.3. Formulations of Active Pharmaceutical Ingredients with Ionic Liquids for Drug Delivery
  • 7.4. Summary and Conclusions
• Chapter 8. Ionic Liquids in Acylglycerol Synthesis and Modification
  • 8.1. Introduction
  • 8.2. Enzymatic Production of Monoacylglycerols Assisted by Ionic Liquids
  • 8.3. Enzymatic Production of Diacylglycerols Assisted by Ionic Liquids
  • 8.4. Future Perspectives
• Chapter 9. Ionic Liquids in Lipid Extraction and Recovery
  • 9.1. Introduction
  • 9.2. The Extraction Process
  • 9.3. The Extraction Unit Operation
  • 9.4. The Recovery Unit Operation
  • 9.5. Molecular Modeling and Simulation
  • 9.6. Future Trends
• Chapter 10. Ionic Liquids in the Synthesis of Antioxidant Targeted Compounds
  • 10.1. Introduction
  • 10.2. Extraction of Natural Antioxidants with Ionic Liquids
  • 10.3. Incentives of Antioxidants Modification
  • 10.4. Modification of Antioxidants in Ionic Liquids
  • 10.5. Antioxidant Synthesis in Ionic Liquids
  • 10.6. Summary and Future Perspectives
• Chapter 11. Ionic Liquids in the Synthesis of Sugar/Carbohydrate and Lipid Conjugates
  • 11.1. Introduction
  • 11.2. Potential Carbohydrate Fatty Acid Esters: Availability and Properties
  • 11.3. Production Strategy of Carbohydrate Fatty Acid Esters
  • 11.4. Role of Ionic Liquids in Enzymatic Synthesis of Carbohydrate Fatty Acid Esters
  • 11.5. Role of Ionic Liquid in Chemical Synthesis of Carbohydrate Fatty Acid Esters
  • 11.6. Remarks and Future Aspects
• Chapter 12. Ionic Liquids in the Production of Biodiesel and Other Oleochemicals
  • 12.1. Production of Biodiesel
  • 12.2. Preparation of Biolubricants
  • 12.3. Preparation of Polymers and Plasticizers
  • 12.4. Preparation of Other Oleochemicals
  • 12.5. Conclusion
• Chapter 13. Toxicity of Ionic Liquids: Past, Present, and Future
  • 13.1. Past: Extensive Studies on Ionic Liquid Toxicity
  • 13.2. Present: Understanding the Molecular Basis of Ionic Liquid Toxicity
  • 13.3. Future: Moving Beyond Toxicity Toward New Potential Applications
• Chapter 14. Ionic Liquids in Lipid Analysis
  • 14.1. Introduction
  • 14.2. Ionic Liquids in Gas Chromatography Analysis
  • 14.3. Ionic Liquids in Liquid Chromatography Analysis
  • 14.4. Ionic Liquids as MALDI Matrices
  • 14.5. Ionic Liquids in Capillary Electrophoresis Analysis Technique
  • 14.6. Application of Ionic Liquids in Enrichment of n-3 Polyunsaturated Fatty Acids/Esters
  • 14.7. Prospects
• Index