Preface (J.P. Andersen). Reaction Mechanism of the Sarcoplasmic Recticulum Ca2+-ATPase (H. Wolser, S. Engelender, and L. de Meis). The ATP Binding Sites of P-Type Ion Transport ATPases: Properties, Structure, Conformations, and Mechanism of Energy Coupling (D.B. McIntosh). The Gastric H+-K+-ATPase (J.M. Shin, D. Bayle, K. Bamberg and G. Sachs). Genetic Approaches to Structure-Function Analysis in the Yeast Plasma Membrane H+-ATPase (D.S. Perlin and J.E. Haber). Copper Homeostatsi by CPX-Type ATPases: The New Subclass of Heavy Metal P-Type ATPases (M. Solioz). Isosform Diversity and Regulation of Organellar-Type Ca2+-Transport ATPases (F. Wuytack, L. Raeymaekers, J. Eggermont, L. Van Den Bosch, H. Verboornen, and L. Mertens).
Both eukaryotic and prokaryotic cells depend strongly on the function of ion pumps present in their membranes. The term ion pump, synonymous with active ion-transport system, refers to a membrane-associated protein that translocates ions uphill against an electrochemical potential gradient. Primary ion pumps utilize energy derived from chemical reactions or from the absorption of light, while secondary ion pumps derive the energy for uphill movement of one ionic species from the downhill movement of another species.
In the present volume, various aspects of ion pump structure, mechanism, and regulation are treated using mostly the ion-transporting ATPases as examples. One chapter has been devoted to a secondary ion pump, the Na+-Ca2+ exchanger, not only because of the vital role played by this transport system in regulation of cardiac contractility, but also because it exemplifies the interesting mechanistic and structural similarities between primary and secondary pumps.
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- © Elsevier Science 1998
- 19th November 1997
- Elsevier Science
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Institute of Physiology, University of Aarhus, Aarhus, Denmark