Investigating Biological Systems Using Modeling

1st Edition

Strategies and Software


  • Meryl Wastney
  • Blossom Patterson
  • Oscar Linares
  • Peter Greif
  • Raymond Boston
  • Investigating Biological Systems Using Modeling

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    Investigating Biological Systems Using Modeling describes how to apply software to analyze and interpret data from biological systems. It is written for students and investigators in lay person's terms, and will be a useful reference book and textbook on mathematical modeling in the design and interpretation of kinetic studies of biological systems. It describes the mathematical techniques of modeling and kinetic theory, and focuses on practical examples of analyzing data. The book also uses examples from the fields of physiology, biochemistry, nutrition, agriculture, pharmacology, and medicine.

    Key Features

    @introbul:Key Features: @bul:* Contains practical descriptions of how to analyze kinetic data * Provides examples of how to develop and use models * Describes several software packages including SAAM/CONSAM * Includes software with working models


    Graduate students and professionals in the fields of medicine, physiology, biochemistry, biomathematics, pharmacology, agricultural systems, nutrition, and animal science.

    Table of Contents

    Introduction: What is Modeling? The Steps in Building a Model. The Difference Between Building a Model and Using a Model. Why Model Biological Systems? Modeling Software: Review of Software. WinSAAM. Concepts and Tools of Modeling: Building Models in Sections. Techniques and Tools to Facilitate Model Development. Strategies for Modeling Biological Systems: Experimental Design and Data Collection. Starting Modeling and Developing a Model. Rejecting Hypotheses and Accepting a Model. Model Summarization. Multiple Studies Analysis. Information in the Model. Errors in Compartmental Modeling. Testing Robustness: Sensitivity, Identifiability, and Stability. Evaluating and Using Published Models: Why Use a Published Model? Reviewing and Summarizing Published Models. The Model Translation Process. Verification and Validation. Using the Model. A Library of Models. Subject Index. Appendices.


    No. of pages:
    © 1999
    Academic Press
    Print ISBN:
    Electronic ISBN:

    About the authors

    Meryl Wastney

    Meryl Wastney is an Associate Professor in the Department of Pediatrics and the Department of Biomathematics and Biostatistics at the Georgetown University Medical Center in Washington D.C. She received her Ph.D. in biochemistry from Lincoln College at the University of Canterbury in New Zealand. She was a Fogarty Fellow in the Laboratory of Mathematical Biology, NCI, NIH, Bethesda, Maryland for three years and joined the Department of Pediatrics at Georgetown University in 1983. She is the author of 30 articles and has presented over 40 invited lectures and workshops on modeling biological systems.

    Affiliations and Expertise

    Georgetown University Medical Center, Washington, D.C.

    Blossom Patterson

    Affiliations and Expertise

    National Cancer Institute, Bethesda, Maryland, U.S.A.

    Oscar Linares

    Affiliations and Expertise

    Biomodeling Unit, Oakwood Healthcare System Southgate Center, Southgate, Michigan, U.S.A.

    Peter Greif

    Affiliations and Expertise

    National Cancer Institute, National Institutes of Health, Bethesda, Maryland, U.S.A.

    Raymond Boston

    Affiliations and Expertise

    School of Veterinary Medicine, Clinical Studies, Kennett Square, PA