- Retinal Determination: The Beginning of Eye Development
- Eye Field Specification in Xenopus laevis
Justin P. Kumar
Michael E. Zuber
- Eye Morphogenesis and Patterning of the Optic Vesicle
- Two themes on the assembly of the Drosophila eye
- Building a Fly Eye: Terminal Differentiation Events of the Retina, Corneal Lens, and Pigmented Epithelia
- Retinal Progenitor Cells, Differentiation and Barriers to Cell Cycle Re-Entry
Charlton-Perkins M and Cook TA
Denise M. Davis and Michael A. Dyer
7. Planar Cell Polarity Signaling in the Drosophila Eye
8. Generating specific synaptic connections between the eyes and the brain
Nicko J. Josten and Andrew D. Huberman
Vision is our primary sensory modality, and we are naturally curious as to how the visual system assembles. The visual system is in many ways remarkably simple, a repeating assemblage of neurons and support cells that parse the visual field through precision and redundancy. Through this simplicity the eye has often led the way in our exploration of how an organ is assembled. Eye development has therefore long been a favorite for exploring mechanisms of cell fate choice, patterning and cell signaling.
This volume, which is part of the Current Topics in Developmental Biology series, highlights the exceptional advances over the past 20 years. Chapters emphasize our knowledge of transcription factors and how these generate networks to direct the eye field and associated structures. Topics such as cell fate specification are also explored, along with the potential of Drosophila as a model for lens formation and the progress made in using the Drosophila eye to examine planar cell polarity.
- Contributions from researchers who are active in identifying new paradigms to explore
- Review of our current state of knowledge
- Chapters written by authors with a new generation approach that takes a more systems approach to identifying factors and better defines cell subtypes
Researchers in cell, developmental, and molecular biology; genetics
- No. of pages:
- © Academic Press 2010
- 27th October 2010
- Academic Press
- eBook ISBN:
- Hardcover ISBN:
Dr. Reh is Professor of Biological Structure and Director of the Neurobiology and Behavior Program at the University of Washington. He is currently a member of the Scientific Advisory Board of the Foundation Fighting Blindness, and of a start-up biotechnology company, Acucela. He has received several awards for his work, including the AHFMR and Sloan Scholar awards and has published over 100 journal articles, reviews and books. Funded by numerous N.I.H. and private foundation grants, his lab is focused on the development and repair of the retina, with an overall goal of understanding the cellular and molecular biology of regeneration in the eye.
University of Washington, Seattle, U.S.A.