Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. Thus, it is rather difficult to grasp the broad impact of sirtuins in biology, and a book like this will be very useful as it will integrate diverse areas of knowledge. Introductory Review on Sirtuins in Biology and Disease integrates this knowledge and provides a current view of the sirtuin field.
This comprehensive reference provides key insights for scientists as well as advanced students who need basic knowledge of sirtuins and current research status in this field. Pharmaceutical companies will use this book for their development of novel targets by using sirtuins for metabolic diseases, cancer, and neurodegenerative diseases.
- Covers both general and more specific aspects of sirtuin proteins and their role in biology, aging and disease
- Top quality collection of leading experts on a rather wide range of sirtuin-related topics
Biochemists, genetics, molecular biology, system biology, translational research and drug discovery
1. Early Sirtuin Research 1991-2000
2. Regulation of sirtuins by systemic NAD+ biosynthesis
3. NAD modulation - biology and therapy
4. The enzymatic activity of sirtuins
5. Molecular mechanisms of Sirtuin activation and inhibition
6. Pharmacological approaches for modulating sirtuins
7. Mitochondrial Sirtuins
8. Biological Roles and Activities for Mitochondrial Sirtuins
9. The multitasking roles of the mammalian deacetylase SIRT6
10. Chromatin and nuclear signaling: SIRT7 function in the nucleolus and beyond
11. Sirtiuns and Carcinogenesis
12. Roles for sirtuins in cardiovascular biology
13. Sirtuins in Brain Biology and Disease
- No. of pages:
- © Academic Press 2018
- 1st May 2018
- Academic Press
- Paperback ISBN:
American biologist best known for his research on life span extension in the budding yeast Saccharomyces cerevisiae, round worms (Caenorhabditis elegans), and mice. He is currently a Novartis Professor of Biology at the Massachusetts Institute of Technology. Based on the discovery that SIR2 is a key regulator of longevity in both yeast and worms, he is interested in determining whether this highly conserved gene also governs longevity in other organisms, including mammals. In 1999, Guarente became co-founder of Elixir Pharmaceuticals, which aimed to develop drugs targeting sirtuin. Leonard Guarente wrote an autobiography in 2003 titled Ageless Quest: One Scientist's Search for Genes That Prolong Youth. He is founder of technology start-up Elysium Health.
Department of Biology Massachusetts Institute of Technology, Cambridge, MA, USA
Raul Mostoslavsky received his M.D. from the University of Tucuman in Argentina and his Ph.D. from the Hebrew University in Jerusalem, Israel. His longstanding interest in basic science and regenerative medicine brought him to Harvard Medical School to pursue postdoctoral studies with stem cells and gene therapy. In 2008 Dr. Mostoslavsky opened his own lab at Boston University. He is currently Associate Professor of Medicine in the Section of Gastroenterology in the Department of Medicine at Boston University School of Medicine. His main research interests are stem cells, disease modeling, regenerative medicine, gene correction and lentiviral vectors as tools for gene transfer. Dr. Mostoslavsky is a founder and Co-Director of the BU Center for Regenerative Medicine (CReM).
Department of Medicine, Massachusetts General Hospital, Boston, MA, USA
Alex Kazantsev received his bachelor's degree in biology and chemistry from Moscow Pedagogical University. As a graduate student he was enrolled in the Genetics, Molecular Biology and Biotechnology Program at the University of North Carolina at Chapel Hill and completed his PhD thesis in 1997. Dr. Kazantsev then joined David Housman's laboratory at the Massachusetts Institute of Technology, where he started work on cellular models of neurodegeneration. At MIT he developed a strong interest in drug discovery, and worked on the development of high-throughput drug screening assays. Through involvement in collaborative work with Genzyme Corporation, he became co-inventor on a few patent applications, disclosing novel neurodegenerative assays and therapeutic agents. He discovered an inhibitor of polyglutamine aggregation, which was neuroprotective in a Huntington’s disease mouse model, and published extensively in the field of Huntington’s disease and drug discovery. In 2002 Dr. Kazantsev was named assistant professor of neurology at Harvard Medical School and principal investigator at Massachusetts General Hospital, where he continued to pursue his interest in drug discovery for neurodegenerative diseases, setting up a high-throughput drug screening facility and in collaboration with other investigators performing drug screens targeting various neurodegenerative disorders. Currently he is a co-PI on a collaborative research project with Novartis toward the development of a cure for Huntington’ s disease.
MassGeneral Institute for Neurodegenerative Disease, Charlestown, MA, USA