Introduction to the Principles of Drug Design - 1st Edition - ISBN: 9780723606727, 9781483183503

Introduction to the Principles of Drug Design

1st Edition

Authors: H. J. Smith Hywel Williams
eBook ISBN: 9781483183503
Imprint: Butterworth-Heinemann
Published Date: 1st January 1983
Page Count: 306
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Description

Introduction to the Principles of Drug Design provides a framework of fundamental drug design and principles into which drugs following on developments may be fitted. This book presents the rationales behind the design of drugs. Organized into nine chapters, this book begins with an overview of how the body handles a drug in terms of absorption, metabolism, distribution, and excretion. This text then examines the critical drug activity at the receptor site, which is usually related to blood and other distribution fluid levels. Other chapters consider the factors involved in binding a drug, metabolite, or substrate to a receptor. The final chapter deals with the design of chemotherapeutic agent for clinical use in the treatment of human infections. This book is intended for use in undergraduate pharmacy courses in medicinal chemistry and as an aid in similar courses in biochemistry and pharmacology. Graduates in chemistry just entering the pharmaceutical industry will also find this book useful.

Table of Contents


Contents

1 Processes of Drug Handling by the Body

2 The Influence of Formulation On Drug Availability

3 Molecular Size, Shape and Ionization in Drug Action

4 Design of Enzyme Inhibitors (Antimetabolites) As Drugs

5 Metal Complexation, Isosteric Modification and Salt Formation in Drug Design

6 The Chemotherapy of Cancer

7 Relationship of Drug Metabolism to Drug Design

8 Quantitative Structure-Activity Relationships and Drug Design

9 Design of Antimicrobial Chemotherapeutic Agents

Index


Details

No. of pages:
306
Language:
English
Copyright:
© Butterworth-Heinemann 1983
Published:
Imprint:
Butterworth-Heinemann
eBook ISBN:
9781483183503

About the Author

H. J. Smith

Hywel Williams

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